Search results for "hunt"
showing 10 items of 286 documents
Przestępstwo nielegalnego posiadania broni lub amunicji pomimo posiadania pozwolenia na broń – glosa do wyroku Sądu Najwyższego z 16.12.2020 r. (IV K…
2022
Interpretacja art. 263 § 2 k.k. poprzez odwołanie się do treści rozporządzenia Ministra Środowiska z 23.03.2005 r. w sprawie szczegółowych warunków wykonywania polowania i znakowania tusz nie spełnia standardów konstytucyjnych i prowadzi do niedopuszczalnej wykładni rozszerzającej przepis karny. Dodatkowo konieczność rozróżnienia przypadków posiadania niewłaściwej broni lub amunicji przez osoby legitymujące się pozwoleniem na broń i sytuacji osób, które posiadają broń lub amunicję, mimo że w ogóle nie mają pozwolenia na broń, powoduje, że art. 263 § 2 k.k. powinien być uznany za adresowany wyłącznie do tych ostatnich
Ventilation/perfusion ratios measured by multiple inert gas elimination during experimental cardiopulmonary resuscitation
2014
Background During cardiopulmonary resuscitation (CPR) the ventilation/perfusion distribution (VA/Q) within the lung is difficult to assess. This experimental study examines the capability of multiple inert gas elimination (MIGET) to determine VA/Q under CPR conditions in a pig model. Methods Twenty-one anaesthetised pigs were randomised to three fractions of inspired oxygen (1.0, 0.7 or 0.21). VA/Q by micropore membrane inlet mass spectrometry-derived MIGET was determined at baseline and during CPR following induction of ventricular fibrillation. Haemodynamics, blood gases, ventilation distribution by electrical impedance tomography and return of spontaneous circulation were assessed. Inter…
Perimeter leakage current in polymer light emitting diodes
2009
Observation of leakage current paths through the device perimeter in standard poly(phenylene vinylene)-based light-emitting devices is reported. Perimeter leakage currents govern the diode performance in reverse and low positive bias and exhibit an ohmic character. Current density correlates with the perimeter-to-area ratio thus indicating that leakage currents are mainly confined on polymer regions in the vicinity of metallic contact limits (device perimeter). © 2008 Elsevier B.V. All rights reserved.
Efectos del compuesto 4QMn en ratones zQ175neo como modelo murino de la enfermedad neurodegenerativa de Huntington
2022
La enfermedad de Huntington (EH) es un grave trastorno neurodegenerativo autosómico dominante caracterizado por una combinación de síntomas motores, cognitivos y psiquiátricos. Su causa es la expansión de una secuencia de repeticiones CAG en el gen HTT, que codifica una versión mutada de la proteína Huntingtina (Yapijakis, 2017). Esta secuencia expandida origina cambios conformacionales que propician la formación de agregados tanto citosólicos como nucleares y, con ello, alteraciones intracelulares, toxicidad y pérdida neuronal (Nance, 2017). La progresión inevitable de la patología resulta en la muerte de las personas con EH entre 5 y 20 años después de la manifestación de sus síntomas (Ka…
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
2004
AbstractPolyglutamine expansion (polyQ) in the protein huntingtin is pathogenic and responsible for the neuronal toxicity associated with Huntington's disease (HD). Although wild-type huntingtin possesses antiapoptotic properties, the relationship between the neuroprotective functions of huntingtin and pathogenesis of HD remains unclear. Here, we show that huntingtin specifically enhances vesicular transport of brain-derived neurotrophic factor (BDNF) along microtubules. Huntingtin-mediated transport involves huntingtin-associated protein-1 (HAP1) and the p150Glued subunit of dynactin, an essential component of molecular motors. BDNF transport is attenuated both in the disease context and b…
Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons
2011
Transport of mRNAs to diverse neuronal locations via RNA granules serves an important function in regulating protein synthesis within restricted sub-cellular domains. We recently detected the Huntington's disease protein huntingtin (Htt) in dendritic RNA granules; however, the functional significance of this localization is not known. Here we report that Htt and the huntingtin-associated protein 1 (HAP1) are co-localized with the microtubule motor proteins, the KIF5A kinesin and dynein, during dendritic transport of β-actin mRNA. Live cell imaging demonstrated that β-actin mRNA is associated with Htt, HAP1, and dynein intermediate chain in cultured neurons. Reduction in the levels of Htt, H…
Deregulated Splicing Is a Major Mechanism of RNA-Induced Toxicity in Huntington's Disease.
2019
Huntington's disease (HD) is caused by an expanded CAG repeat in the huntingtin (HTT) gene, translating into an elongated polyglutamine stretch. In addition to the neurotoxic mutant HTT protein, the mutant CAG repeat RNA can exert toxic functions by trapping RNA-binding proteins. While few examples of proteins that aberrantly bind to mutant HTT RNA and execute abnormal function in conjunction with the CAG repeat RNA have been described, an unbiased approach to identify the interactome of mutant HTT RNA is missing. Here, we describe the analysis of proteins that preferentially bind mutant HTT RNA using a mass spectrometry approach. We show that (I) the majority of proteins captured by mutant…
Neuroendoscopic Navigated One-Step Removal of Crossed Ventricular Catheter Fragments: Technical Note
2021
Abstract Introduction Neuroendoscopy plays an important role in minimally invasive neurosurgery. The authors reported an interesting case of a pediatric patient with multiple ventriculoperitoneal shunt (VPS) revision surgeries, presenting with VPS infection and with two crossed intraventricular floating catheter fragments, successfully removed through a neuroendoscopic navigated one-step procedure. A literature review regarding this exceedingly rare condition has also been discussed. Case Description An 11-year-old female patient with a history of congenital hydrocephalus was admitted to the emergency department with symptoms of intracranial hypertension, psychomotor agitation, and tetrapar…
Mesolithic pit-sites in Champagne (France): First data, key issues
2015
International audience; In less than a decade, more than 30 sites and around 200 deep pits dated to the Mesolithic have been identied in the Champagne-Ardenne region (north-eastern France). This paper describes the main characteristics of these features and provides some clues for their interpretation. This unexpected but apparently common type of site clearly implies a more marked territoriality and a greater social complexity than generally proposed for the period in continental northern France.