Search results for "hunting"

Rifampin-impregnated silicone catheters: a potential tool for prevention and treatment of CSF shunt infections.

2003

Background: Infection continues to be one of the major complications of cerebro-spinal fluid shunting procedures. Recent insights in the pathophysiological mechanism of these foreign body infections have elucidated the difficulty of achieving successful treatment without device removal. The development of a rifampin-impregnated silicone catheter yielded excellent results in infection prevention and treatment in vitro as well as in an animal model. Patients and Methods: Here, we describe the application of this device in two patients with a complicated course of shunt infection. Results: In one patient the rifampin-impregnated shunt system was implanted after external drainage to prevent fur…

Huntington: hablar inglés o morir

2004

The "Mathematical Table" in the Chinese Lodge of Palermo

2015

The end of the 18th century sees the decline of the late baroque and rococo in the decorative arts and the origin of the neoclassic essentiality. Nonetheless, the spirit of competition among the members of the European courts and of the aristocracy in erecting magnificent residences inside spectacular parks, full of astonishing pieces of furniture, is still alive and floods of money are spent without restraint. In this very period, a new curious type of dining table makes its appearance in the aristocratic dwelling houses and precisely in the hunting lodge of the Bourbon Court close to the city of Palermo in Sicily: the "Mathematical Table". This name is due to the fantasy of its designer, …

The

2016

ABSTRACT Members of the Junctophilin (JPH) protein family have emerged as key actors in all excitable cells, with crucial implications for human pathophysiology. In mammals, this family consists of four members (JPH1-JPH4) that are differentially expressed throughout excitable cells. The analysis of knockout mice lacking JPH subtypes has demonstrated their essential contribution to physiological functions in skeletal and cardiac muscles and in neurons. Moreover, mutations in the human JPH2 gene are associated with hypertrophic and dilated cardiomyopathies; mutations in JPH3 are responsible for the neurodegenerative Huntington's disease-like-2 (HDL2), whereas JPH1 acts as a genetic modifier …

L26 The Role Of Occupational Therapy In Huntington's Disease

2014

Background We discuss the role of the occupational therapist working with individuals and families affected by Huntington’s disease. Objectives A research by purposes was carried out through the design and implementation of an intervention program aimed at preventing and alleviating the deterioration caused by the disease through training in daily living activities and cognitive stimulation, and coaching the families through monthly monitoring and annual meetings. Method A literature review using structured databases was conducted to identify studies focusing on Occupational Therapy in Huntington’s disease. An intervention program based on the different types, symptoms and stages of the dis…

The Utility of BDNF Detection in Assessing Severity of Huntington's Disease.

2021

Brain-derived neurotrophic factor (BDNF) is involved in the survival and maturation of neurons, and also promotes and controls neurogenesis. Its levels are lowered in many neurodegenerative diseases, including Huntington’s disease (HD). Clinical pictures of HD can be very diverse, which makes it difficult to assess its severity

Modelling the spatial and temporal constrains of the GABAergic influence on neuronal excitability

2021

GABA (γ-amino butyric acid) is an inhibitory neurotransmitter in the adult brain that can mediate depolarizing responses during development or after neuropathological insults. Under which conditions GABAergic membrane depolarizations are sufficient to impose excitatory effects is hard to predict, as shunting inhibition and GABAergic effects on spatiotemporal filtering of excitatory inputs must be considered. To evaluate at which reversal potential a net excitatory effect was imposed by GABA (EGABAThr), we performed a detailed in-silico study using simple neuronal topologies and distinct spatiotemporal relations between GABAergic and glutamatergic inputs. These simulations revealed for GABAe…

Effect of depolarizing GABAA-mediated membrane responses on excitability of Cajal-Retzius cells in the immature rat neocortex

2011

In immature neurons activation of ionotropic GABA receptors induces depolarizing membrane responses due to a high intracellular Cl− concentration ([Cl−]i). However, it is difficult to draw conclusions about the functional consequences of subthreshold GABAergic depolarizations, since GABAergic membrane shunting and additional effects on voltage-dependent ion channels or action potential threshold must be considered. To systematically investigate factors that determine the GABAergic effect on neuronal excitability we performed whole cell patch-clamp recordings from Cajal-Retzius cells in immature rat neocortex, using [Cl−]i between 10 and 50 mM. The effect of focal GABA application was quant…

Antioxidants as treatment for neurodegenerative disorders.

2002

Oxidative stress is a ubiquitously observed hallmark of neurodegenerative disorders. Neuronal cell dysfunction and cell death due to oxidative stress may causally contribute to the pathogenesis of progressive neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, as well as acute syndromes of neurodegeneration, such as ischaemic and haemorrhagic stroke. Neuroprotective antioxidants are considered a promising approach to slowing the progression and limiting the extent of neuronal cell loss in these disorders. The clinical evidence demonstrating that antioxidant compounds can act as protective drugs in neurodegenerative disease, however, is still relatively scarce. …

TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures.

2020

Glutamatergic and GABAergic synaptic transmission controls excitation and inhibition of postsynaptic neurons, whereas activity of ion channels modulates neuronal intrinsic excitability. However, it is unclear how excessive neuronal excitation affects intrinsic inhibition to regain homeostatic stability under physiological or pathophysiological conditions. Here, we report that a seizure-like sustained depolarization can induce short-term inhibition of hippocampal CA3 neurons via a mechanism of membrane shunting. This depolarization-induced shunting inhibition (DShI) mediates a non-synaptic, but neuronal intrinsic, short-term plasticity that is able to suppress action potential generation and…