Search results for "hyperoxemia"

showing 5 items of 5 documents

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: Insights from the LUNG SAFE study

2020

Abstract Background Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence o…

ARDSmedicine.medical_treatment030204 cardiovascular system & hematologyCritical Care and Intensive Care MedicineHyperoxemiaHypoxemialaw.inventionHypoxemia0302 clinical medicinelawFraction of inspired oxygenOxygen therapyPrevalenceMedicineHypoxiaAcute respiratory distress syndrome; Hyperoxemia; Hyperoxia; Hypoxemia; Hypoxia; Invasive mechanical ventilation; Mortality; Oxygen therapy;Respiratory Distress SyndromeHyperbaric OxygenationAcute respiratory distress syndromeRespirationlcsh:Medical emergencies. Critical care. Intensive care. First aidHyperoxemiaIntensive care unitIntensive Care UnitsAnesthesiaArtificialmedicine.symptomHumanArtificial ventilationAcute respiratory distress syndrome; Hyperoxemia; Hyperoxia; Hypoxemia; Hypoxia; Invasive mechanical ventilation; Mortality; Oxygen therapyIntensive Care UnitHyperoxiaNO03 medical and health sciencesIntensive careSettore MED/41 - ANESTESIOLOGIAHumansInvasive mechanical ventilationMortalitybusiness.industryResearchRespiratory Distress Syndrome Adultlcsh:RC86-88.9medicine.diseaseOxygen therapyRespiration Artificialrespiratory tract diseasesOxygenlnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]030228 respiratory systembusiness
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Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO …

2023

Background: In acute brain injury (ABI), the effects of hypoxemia as a potential cause of secondary brain damage and poor outcome are well documented, whereas the impact of hyperoxemia is unclear. The primary aim of this study was to assess the episodes of hypoxemia and hyperoxemia in patients with ABI during the intensive care unit (ICU) stay and to determine their association with in-hospital mortality. The secondary aim was to identify the optimal thresholds of arterial partial pressure of oxygen (PaO2) predicting in-hospital mortality. Methods: We conducted a secondary analysis of a prospective multicenter observational cohort study. Adult patients with ABI (traumatic brain injury, suba…

OxygenBrain injuryHyperoxiaCritically illHyperoxemiaOutcome
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Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen

2003

Although room air is adequate for resuscitating asphyxiated newborn infants, guidelines recommend using 100% oxygen. Hyperoxemia, as has been noted in animal studies, could cause delayed breathing, increased oxygen consumption, and disordered cerebral circulation. In addition, 100% oxygen has caused prolonged oxidation of blood glutathione in neonates. In this study, 51 asphyxiated neonates born at term were randomly assigned to resuscitation with room air (RAR) and 55 to resuscitation with 100% oxygen (OxR). The goal was to learn whether using oxygen for resuscitation triggers oxidative stress. Critical criteria were the Apgar score, the time of the first cry, and sustained respiration. Si…

ResuscitationResuscitationGlutathione reductasemedicine.disease_causechemistry.chemical_compoundDouble-Blind MethodmedicineHumansAcidosisAsphyxiachemistry.chemical_classificationAsphyxia NeonatorumGlutathione DisulfideSuperoxide Dismutasebusiness.industryGlutathione peroxidaseInfant NewbornOxygen Inhalation TherapyObstetrics and GynecologyApneaHyperoxemiaGeneral MedicineGlutathioneCarbon DioxideFetal BloodGlutathioneOxygenOxidative StressGlutathione ReductasechemistryAnesthesiaPediatrics Perinatology and Child HealthBreathingApgar ScoreRoom air distributionApgar scoremedicine.symptombusinessOxidative stressThe Journal of Pediatrics
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Hyperoxemia caused by resuscitation with pure oxygen may alter intracellular redox status by increasing oxidized glutathione in asphyxiated newly bor…

2002

In a prospective, randomized, blinded trial we have studied the effects of resuscitation upon oxygenation in a group of asphyxiated newly born infants receiving room air or 100% oxygen as the gas source. During the acute phase of asphyxia and until the resuscitation procedure concluded, we determined serial blood gases as well as reduced and oxidized glutathione, enzymes involved in the glutathione redox cycle, and antioxidant enzyme activities. The use of 100% oxygen caused a remarkable increase of partial pressures of oxygen in arterial blood, with values that were frequently above physiological levels (>100 mm Hg). In addition, we have found a significant correlation between hyperoxemia …

medicine.medical_specialtyResuscitationAntioxidantResuscitationmedicine.medical_treatmentchemistry.chemical_elementHyperoxiamedicine.disease_causeOxygenStatistics Nonparametricchemistry.chemical_compoundInternal medicinemedicineHumansProspective StudiesGlutathione TransferaseAsphyxia NeonatorumGlutathione PeroxidaseGlutathione Disulfidebusiness.industryAirInfant NewbornOxygen Inhalation TherapyObstetrics and GynecologyHyperoxemiaGlutathioneOxygenationGlutathioneOxygenGlutathione ReductaseEndocrinologychemistryAnesthesiaPediatrics Perinatology and Child HealthApgar ScoreArterial bloodBlood Gas AnalysisbusinessOxidation-ReductionOxidative stressSeminars in Perinatology
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Effects of hyperoxemia in patients with sepsis – A post-hoc analysis of a multicentre randomized clinical trial

2023

Background Administration of supplemental oxygen is a life-saving treatment in critically ill patients. Still, optimal dosing remains unclear during sepsis. The aim of this post-hoc analysis was to assess the association between hyperoxemia and 90-day mortality in a large cohort of septic patients. Methods This is a post-hoc analysis of the Albumin Italian Outcome Sepsis (ALBIOS) randomized controlled trial (RCT). Patients with sepsis who survived the first 48 h since randomization were included and stratified into two groups according to their average PaO2 levels during the first 48 h (PaO2 0–48 h). The cut-off value was established at 100 mmHg (average PaO2 0–48 h >100 mmHg: hyperoxemi…

sepsisPulmonary and Respiratory MedicinehyperoxemiaPulmonology
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