Search results for "hyperparathyroidism"
showing 10 items of 57 documents
Short Ammonium Chloride Loading Test for Evaluation of Hyperparathyroidism
1981
The dilemma in the diagnosis of hyperparathyroidism (HPT) is reflected by three factors: Hypercalcemia is still regarded as the most important diagnostic sign, but unless multiple determinations of serum calcium are done, the so-called borderline cases will be missed. Tests that readily identify HPT combine either simple performance, widespread use and low accuracy (CP, TRP, PEI, TMP/GFR)l or sophisticated methods, limited use and high accuracy (PTH, Ca+++, c-AMP). Consequently, some authors perform neck explorations to cure patients with recurrent nephrolithiasis who do not fulfill the diagnostic criteria of HPT. However, the stone recurrence rate may then reach 75%2,3 In this situation, t…
Management of secondary hyperparathyroidism in uremic patients : the role of the new vitamin D analogs
2007
Secondary hyperparathyroidism - a common comorbid condition in patients with chronic renal insufficiency - is considered a consequence of critical determinants such as hypocalcemia, phosphate retention and reduced levels of calcitriol production. In this complex mechanism, the skeletal apparatus and the nonskeletal targets such as vascular and heart valves are often involved, thus explaining the increased risk of cardiovascular morbidity and mortality of uremic patients. In this review we will focus on the major role played by Calcitriol deficiency as a trigger of secondary hyperparathyroidism and the crucial need for obiquitous vitamin D receptor activation in order to have an optimal PTH …
Osteoporosis, densidad mineral ósea y complejo CKD-MBD (I): consideraciones diagnósticas
2018
Resumen: Osteoporosis (OP) y enfermedad renal crónica (ERC) influyen de manera independiente en la salud ósea y cardiovascular. Un número significativo de pacientes con ERC, especialmente desde estadios 3a a 5D, presentan una disminución significativa de la densidad mineral ósea condicionando un alto riesgo de fractura y un incremento importante de la morbimortalidad asociada. Independientemente de la OP clásica asociada a edad y/o sexo, las propiedades mecánicas del hueso se encuentran afectadas adicionalmente por factores intrínsecos a la ERC («OP urémica»). En la primera parte de esta revisión, analizaremos conceptos generales sobre densidad mineral ósea, OP y fracturas, en gran parte in…
Dissimilar PTH, Gastrin, and Calcitonin Responses to Oral Calcium and Peptones in Hypocalciuric Hypercalcemia, Primary Hyperparathyroidism, and Norma…
2005
We analyzed gastrin, PTH, and calcitonin responses to oral calcium and peptones in hypocalciuric hypercalcemia, mild primary hyperparathyroidism, and normal controls. We observed diverse hormonal responses that may help in the differential diagnosis of these conditions. Introduction: Hypocalciuric hypercalcemia (HH) is consequent to calcium-sensing receptor (CaSR) genetic mutations or anti-CaSR antibodies. CaSR is expressed in parathyroid tissue, thyroid C cells, and gastrin-secreting cells, where it has been suggested that on calcium and/or amino acid allosteric activation, promotes gastrin secretion. Materials and Methods: We evaluated gastrin, PTH, and calcitonin responses to oral calciu…
Mandibular brown tumor as the first manifestation of primary hyperparathyroidism: a case report
2013
SP619The effect of etelcalcetide in hemodialysis patients with secondary hyperparathyroidism in daily clinical practice. A prospective multicenter st…
2019
Lebensqualität nach operativer Therapie des renalen Hyperparathyreoidismus. Ergebnisse einer prospektiven Langzeitstudie / Quality of Life After Oper…
2001
In einer prospektiven Langzeituntersuchung wurde die Lebensqualitat nach operativer Therapie des renalen Hyperparathyreoidismus untersucht. Vom 1.8.1987-31.8.2000 erfolgten 186 Eingriffe. Bevorzugte Operation war die totale Parathyreoidektomie mit autologer Epithelkorperchenreplantation. Die Erfolgsrate der erstmaligen Halsexploration betrug 98,2%. Juckreiz klang bei uber 60% der betroffenen Patienten innerhalb von 4 Wochen nach dem Eingriff ab. Die Ruckbildung ossarer Symptome bedurfte langerer Zeit. Ein Jahr postoperativ waren 75% der praoperativ von Juckreiz und 79% der vom ossaren Syndrom betroffenen Patienten asymptomatisch. Patienteneigene Risikofaktoren bedingen eine niedrige Letalit…
Parathyroid hormone and insulin-resistance in essential hypertension
2000
Risk Profiles and Penetrance Estimations in Multiple Endocrine Neoplasia Type 2A Caused by Germline RET Mutations Located in Exon 10
2010
Multiple endocrine neoplasia type 2 is characterized by germline mutations in RET. For exon 10, comprehensive molecular and corresponding phenotypic data are scarce. The International RET Exon 10 Consortium, comprising 27 centers from 15 countries, analyzed patients with RET exon 10 mutations for clinical-risk profiles. Presentation, age-dependent penetrance, and stage at presentation of medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism were studied. A total of 340 subjects from 103 families, age 4-86, were registered. There were 21 distinct single nucleotide germline mutations located in codons 609 (45 subjects), 611 (50), 618 (94), and 620 (151). MTC was present…