Search results for "iNOS"
showing 10 items of 2075 documents
Hemodilution in isolated tumor perfusion.
1984
Experiments are performed to study the influence of local hemodilution on tumor blood flow, oxygen availability in tumor tissue and O2 consumption of cancer cells. The results obtained clearly show that hemodilution in isolated tumor perfusion can distinctly improve nutritive blood flow through solid tumors. This can be utilized to enhance pharmacokinetics of antitumor drugs. Due to the improved metabolic status, the pharmacodynamics of some antitumor drugs should also be enhanced. To achieve a maximum improvement of the O2 supply to the tumor, hematocrit values should not be decreased below 0.20.
The Synergistic Effect of SAHA and Parthenolide in MDA-MB231 Breast Cancer Cells
2015
The sesquiterpene lactone Parthenolide (PN) exerted a cytotoxic effect on MDA-MB231 cells, a triple-negative breast cancer (TNBC) cell line, but its effectiveness was scarce when employed at low doses. This represents an obstacle for a therapeutic utilization of PN. In order to overcome this difficulty we associated to PN the suberoylanilide hydroxamic acid (SAHA), an histone deacetylase inhibitor. Our results show that SAHA synergistically sensitized MDA-MB231 cells to the cytotoxic effect of PN. It is noteworthy that treatment with PN alone stimulated the survival pathway Akt/mTOR and the consequent nuclear translocation of Nrf2, while treatment with SAHA alone induced autophagic activity…
La sala Cervantes de la Biblioteca Nacional
2004
El presente artículo pretende una aproximación iconográfica a la obra plástica de Antonio Muñoz Degraín (1840-1924) inspirada tanto en las aventuras del Quijote como en las desventuras de su celebrado autor. Por tanto, formarán parte de este estudio todas las pinturas que el artista valenciano realizó, entre los años de 1916 y 1919, para ser colgadas en las paredes de la sala Cervantes de la Biblioteca Nacional, cuya inauguración se produjo el 6 de marzo de 1920. (A)
The influence of brassinosteroid on growth and parameters of photosynthesis of wheat and mustard plants.
1984
The growth response of wheat (Triticum aest. L.) and mustard seedlings (Sinapis alba L.) treated with 10(-6) mol · l(-1) brassinosteroid (BR) foliar spray was measured. BR-treatment resulted in a general promotion of plant growth. We found the accumulation of photosynthates to be stimulated in the treated plants, as indicated by enhanced fresh and dry weights of leaves and shoots. BR also promoted the synthesis of soluble proteins and soluble reducing sugars, whereas the chlorophyll content was hardly affected. CO(2)-fixation in vivo as well as the (in vitro) RubPC-ase activity of BR-treated leaves were enhanced. In the developing wheat leaves we detected no difference in the ratio fraction…
Carga y factores de riesgo para la neumonía adquirida en la comunidad de Pseudomonas aeruginosa : un estudio multinacional de prevalencia puntual de …
2018
Pseudomonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa-CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa-CAP. We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa. Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeru…
Proyección y reivindicación de los poetas yahilíes en la poesía árabe contemporánea.
2001
Veglison Elias de Molins, Josefina - Josefina.Veglison@uv.es Este articulo analiza las referencias a poetas de la Yahiliyya presentes en la poesía árabe contemporánea en calidad de mitos y arquetipos. Cabe destacar el hecho de que éstos sean beduinos pertenecientes a la categoría de autores de mu'allaqa o al grupo de poetas bandoleros (sa'álik). El autor contemporáneo rescata sus figuras porque interpreta como signo de modernidad su talante innovador y su rebeldía contra la norma, tanto en lo formal como en los contenidos. Esta reivindicación se lleva a cabo, en los contenidos, mediante la evocación de sus nombres en poemas o títulos de diwanes, la inclusión de sus versos o la réplica a sus…
Constraining the neutrino emission of gravitationally lensed Flat-Spectrum Radio Quasars with ANTARES data
2014
This paper proposes to exploit gravitational lensing effects to improve the sensitivity of neutrino telescopes to the intrinsic neutrino emission of distant blazar populations. This strategy is illustrated with a search for cosmic neutrinos in the direction of four distant and gravitationally lensed Flat-Spectrum Radio Quasars. The magnification factor is estimated for each system assuming a singular isothermal profile for the lens. Based on data collected from 2007 to 2012 by the ANTARES neutrino telescope, the strongest constraint is obtained from the lensed quasar B0218+357, providing a limit on the total neutrino luminosity of this source of 1.08×10^46 erg s-1. This limit is about one o…
Native and planted forest species determine different carbon and nitrogen pools in Arenosol developed on Holocene deposits from a costal Mediterranea…
2016
In a coastal Mediterranean area, the effects of two native [Quercus ilex (Holm), Alnus glutinosa and Fraxinus oxycarpa (Hygro)] and one planted [Pinus pinaster (Pine)] forest species on both content and quality of organic C and total N pools in Arenosols was assessed. Three soil profiles per each forest cover were opened and sampled. Total N in the organic layers was not affected by forest covers, whereas total organic C ranged from 36.1 to 63.2 Mg ha−1, being organic layers under Hygro those with the highest contents. Total organic C in the first 50 cm of mineral soil was 64 Mg ha−1 under Holm and 36.7 and 37.6 Mg ha−1 under Pine and Hygro, respectively. Soil covered by Holm and Hygro stor…
Activation of alpha-1A adrenoceptors mobilizes calcium from the intracellular stores in myocytes from rat portal vein.
1994
International audience; Intracellular free Ca++ concentration ([Ca++]i) was monitored using the fluorescence from the dye fura-2-acetoxymethylester in single myocytes from rat portal vein. In the presence of oxodipine (a L-type Ca++ channel inhibitor), norepinephrine (10 microM) evoked transient increases in [Ca++]i which were related to release of Ca++ from intracellular stores. The alpha-1 adrenoceptors mediating intracellular Ca++ release and inositol phosphate accumulation were identified by using subtype-selective agonists and antagonists. Pretreatment with chloroethylclonidine had little effect on the norepinephrine-induced increase in [Ca++]i and inositol phosphate accumulation. In c…
International student mobility in Southern-Latin Europe: beyond the EU logics, towards a new space
2018
This paper discusses international student mobility (ISM) in Southern-Latin Europe, specifically Italy, Portugal, and Spain, analysing the inflow of international students as reflected in the UNESCO, OECD and European Commission databases. Only recently Italy, Portugal and Spain, as latecomers, have become more actively involved in ISM dynamics. This trend has been a response to EU pressures to internationalization, instrumented through the consolidation of the Bologna process and the need to build a common space of higher education. The analysis shows that at the intra-European level Italy, Portugal and Spain share similar ISM patterns; however, in the global context other logics shape ISM…