6533b834fe1ef96bd129cbac

RESEARCH PRODUCT

Hemodilution in isolated tumor perfusion.

Müller-klieser WP Vaupel

subject

PhysiologyPharmacologyHematocritMicrocirculationOxygen ConsumptionPharmacokineticsCarcinosarcomaPhysiology (medical)CarcinosarcomamedicineAnimalsHemodilutionmedicine.diagnostic_testbusiness.industryMicrocirculationRats Inbred StrainsBlood flowmedicine.diseaseKidney NeoplasmsRatsmedicine.anatomical_structureHematocritRegional Blood FlowPharmacodynamicsCancer cellVascular resistanceVascular ResistancebusinessBlood Flow Velocity

description

Experiments are performed to study the influence of local hemodilution on tumor blood flow, oxygen availability in tumor tissue and O2 consumption of cancer cells. The results obtained clearly show that hemodilution in isolated tumor perfusion can distinctly improve nutritive blood flow through solid tumors. This can be utilized to enhance pharmacokinetics of antitumor drugs. Due to the improved metabolic status, the pharmacodynamics of some antitumor drugs should also be enhanced. To achieve a maximum improvement of the O2 supply to the tumor, hematocrit values should not be decreased below 0.20.

yearjournalcountryeditionlanguage
1984-08-01Biorheology
10.3233/bir-1984-21411https://pubmed.ncbi.nlm.nih.gov/6487764