Search results for "iNOS"
showing 10 items of 2075 documents
Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging
2014
Dietary restriction extends longevity in organisms ranging from bacteria to mice and protects primates from a variety of diseases, but the contribution of each dietary component to aging is poorly understood. Here we demonstrate that glucose and specific amino acids promote stress sensitization and aging through the differential activation of the Ras/cAMP/PKA, PKH1/2 and Tor/S6K pathways. Whereas glucose sensitized cells through a Ras-dependent mechanism, threonine and valine promoted cellular sensitization and aging primarily by activating the Tor/S6K pathway and serine promoted sensitization via PDK1 orthologs Pkh1/2. Serine, threonine and valine activated a signaling network in which Sch…
The inhibitory effect of D-glucosamine on thymidine kinase in chick embryo retinas and HeLa cells
1984
D-Glucosamine markedly inhibits thymidine incorporation into the TCA-insoluble fraction and thymidine kinase activity in HeLa cells. Both the inhibitory effects are also observed in isolated retinas of chick embryos. In this case the inhibitory effects are age-dependent and the magnitude of the responses decreases with embryonic development. In addition the time of exposure to D-glucosamine which is necessary to reveal the inhibitory effect on thymidine kinase increases with the age of the embryos.
Combined use of sonographic and elastosonographic parameters can improve the diagnostic accuracy in thyroid nodules at risk of malignancy at cytologi…
2019
BACKGROUND Thyroid nodules diagnosed as Thy3B at fine-needle aspiration biopsy have a relevant risk of malignancy (15-30%) and are usually addressed to surgery. However surgery will result unnecessary in most cases. The present study aims at evaluating the possible increase of diagnostic accuracy for predicting malignancy using novel sonographic and elastographic parameters. METHODS In fifty patients undergoing thyroidectomy because of a Thy3B thyroid nodule, sonographic and elastosonographic evaluation was carried out by single operator before surgery. Five sonographic parameters (echogenicity, irregular margins, microcalcifications, intra-nodule blood flow and its irregularity) and two el…
Triunfo y caída de un poeta libertino, olvido y recuperación de su obra
2017
Desde su fallecimiento hasta la actualidad, la recepción de la obra poética de Théophile de Viau ha sido diversa. Poeta poco propenso a ajustarse a normas o equilibrios impuesto, los siglos XVII y XVII en Francia fueron poco amables con él, aunque no le faltaron admiradores, sobre todo en los años que siguieron a su muerte, tras su polémico juicio, condena a la hoguera –de la que, por fortuna escapó– y posterior encarcelamiento. Théophile Gautier, con un estudio sobre él publicado en 1834 y que formará parte de su obra Les Grotesques, es uno de los principales artífices de su rehabilitación en el siglo XIX, aunque siguió habiendo en ese período juicios matizados y negativos sobre el poeta. …
Nano into Micro Formulations of Tobramycin for the Treatment of Pseudomonas aeruginosa Infections in Cystic Fibrosis.
2017
Here, nano into micro formulations (NiMs) of tobramycin for the treatment of Pseudomonas aeruginosa airway infections in cystic fibrosis (CF) are described. NiMs were produced by spray drying a solution containing polymers or sugars and a nanometric polyanion–tobramcyin complex (PTC), able to achieve a prolonged antibiotic release. NiMs properties were compared to TOBIPodhaler(Novartis), the only one commercially available dry powder inhalatory formulation based on porous microparticles. Produced NiMs showed adequate characteristics for pulmonary administration, as spherical shape, micrometric size, and high cytocompatibility toward human bronchial epithelial cells. Contrarily to TOBIPodhal…
Search for a heavy top-quark partner in final states with two leptons with the ATLAS detector at the LHC
2012
The results of a search for direct pair production of heavy top-quark partners in 4.7 fb[superscript −1] of integrated luminosity from pp collisions at s√ = 7 TeV collected by the ATLAS detector at the LHC are reported. Heavy top-quark partners decaying into a top quark and a neutral non-interacting particle are searched for in events with two leptons in the final state. No excess above the Standard Model expectation is observed. Limits are placed on the mass of a supersymmetric scalar top and of a spin-1/2 top-quark partner. A spin-1/2 top-quark partner with a mass between 300 GeV and 480 GeV, decaying to a top quark and a neutral non-interacting particle lighter than 100 GeV, is excluded …
Measurement of thett¯production cross section inpp¯collisions ats=1.96 TeVusing soft electronb-tagging
2010
The authors present a measurement of the t{bar t} production cross section using events with one charged lepton and jets from p{bar p} collisions at a center-of-mass energy of 1.96 TeV. A b-tagging algorithm based on the probability of displaced tracks coming from the event interaction vertex is applied to identify b quarks from top decay. Using 318 pb{sup -1} of data collected with the CDF II detector, they measure the t{bar t} production cross section in events with at least one restrictive (tight) b-tagged jet and obtain 8.9{sub -1.0}{sup +1.0}(stat.){sub -1.0}{sup +1.1}(syst.) pb. The cross section value assumes a top quark mass of m{sub t} is presented in the paper. This result is cons…
Cross-section-constrained top-quark mass measurement from dilepton events at the tevatron
2008
We report the first top quark mass measurement that uses a cross section constraint to improve the mass determination. This measurement is made with a dilepton $t\bar{t}$ event sample collected with the CDF II detector. From a data sample corresponding to an integrated luminosity of 1.2 fb$^{-1}$, we measure a top quark mass of $\rm{170.7^{+4.2}_{-3.9}(stat)\pm2.6(syst)}$ $\rm{\pm2.4(theory) GeV/{\it{c}}^{2}}$. The measurement without the cross section constraint results in a top quark mass of $\rm{169.7^{+5.2}_{-4.9}(stat)\pm3.1(syst) GeV/{\it{c}}^{2}}$.
Measurement of the charge asymmetry in top quark pair production in pp collisions at root s=7 TeV using the ATLAS detector
2012
A measurement of the top-antitop production charge asymmetry A[subscript C] is presented using data corresponding to an integrated luminosity of 1.04 fb[superscript −1] of pp collisions at s√=7 TeV collected by the ATLAS detector at the LHC. Events are selected with a single lepton (electron or muon), missing transverse momentum and at least four jets of which at least one jet is identified as coming from a b-quark. A kinematic fit is used to reconstruct the t[bar over t] event topology. After background subtraction, a Bayesian unfolding procedure is performed to correct for acceptance and detector effects. The measured value of A[subscript C] is A[subscript C]=−0.019±0.028 (stat.)±0.024 (s…
Measurement of t ¯ t production with a veto on additional central jet activity in pp collisions at √ s = 7 TeV using the ATLAS detector
2012
A measurement of the jet activity in t[bar over t] events produced in proton–proton collisions at a centre-of-mass energy of 7 TeV is presented, using 2.05 fb[superscript −1] of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. The t[bar over t] events are selected in the dilepton decay channel with two identified b-jets from the top quark decays. Events are vetoed if they contain an additional jet with transverse momentum above a threshold in a central rapidity interval. The fraction of events surviving the jet veto is presented as a function of this threshold for four different central rapidity interval definitions. An alternate measurement is also perfor…