Search results for "iNOS"
showing 10 items of 2075 documents
Interaction of antibodies to proteinase 3 (classic anti-neutrophil cytoplasmic antibody) with human renal tubular epithelial cells: impact on signali…
2002
Abstract Among the anti-neutrophil cytoplasmic Abs (ANCA), those targeting proteinase 3 (PR3) have a high sensitivity and specificity for Wegener’s granulomatosis (WG). A pathogenetic role for these autoantibodies has been proposed due to their capacity of activating neutrophils in vitro. Recently, PR3 was also detected in human renal tubular epithelial cells (TEC). In the present study, the effect of murine monoclonal anti-PR3 Abs (anti-PR3) and purified c-ANCA targeting PR3 from WG serum on isolated human renal tubular cell signaling and inflammatory mediator release was characterized. Priming of TEC with TNF-α resulted in surface expression of PR3, as quantified in immunofluorescence stu…
The THESEUS space mission concept: science case, design and expected performances
2018
THESEUS is a space mission concept aimed at exploiting Gamma-Ray Bursts for investigating the early Universe and at providing a substantial advancement of multi-messenger and time-domain astrophysics. These goals will be achieved through a unique combination of instruments allowing GRB and X-ray transient detection over a broad field of view (more than 1sr) with 0.5¿1 arcmin localization, an energy band extending from several MeV down to 0.3¿keV and high sensitivity to transient sources in the soft X-ray domain, as well as on-board prompt (few minutes) follow-up with a 0.7¿m class IR telescope with both imaging and spectroscopic capabilities. THESEUS will be perfectly suited for addressing …
Disentangling Isoetes setacea and removing threats to Isoetes echinospora
2015
The name Isoetes setacea has been applied to two different species, causing nomenclatural and taxonomic confusion. Some authors have rejected it on that account, yet it is currently used in a sense that is incompatible with its type. That type represents one of two similar species, I. echinospora and I. lacustris, which still today grow together at the type locality. An epitype is designated here, ensuring that I. setacea is sunk in synonymy under I. lacustris. A second name potentially threatening I. echinospora is I. tenella. It is currently regarded as a synonym of I. lacustris, but its type, a plate in Flora Danica, cannot be confidently identified, nor are there any specimens associate…
Dažādu ābolu šķirņu izcelsmes pētījumi
2020
Darbā tika veikta literatūras izpēte par izotopu attiecības un aminoskābju noteikšanu pārtikas produktos. Eksperimentālajā daļā tika pētītas Latvijā audzētu ābolu sēklas. Kopā tika pētītas piecas ābolu šķirnes ar dažādiem apsaimniekošanas veidiem. Paraugiem tika noteikta oglekļa un slāpekļa izotopu attiecība, un aminoskābes. Iegūtie rezultāti tika salīdzināti savā starpā.
Searches for small-scale anisotropies from neutrino point sources with three years of IceCube data
2015
Recently, IceCube found evidence for a diffuse signal of astrophysical neutrinos in an energy range of $60\,\mathrm{TeV}$ to the $\mathrm{PeV}$-scale. The origin of those events, being a key to understanding the origin of cosmic rays, is still an unsolved question. So far, analyses have not succeeded to resolve the diffuse signal into point-like sources. Searches including a maximum-likelihood-ratio test, based on the reconstructed directions and energies of the detected down- and up-going neutrino candidates, were also performed on IceCube data leading to the exclusion of bright point sources. In this paper, we present two methods to search for faint neutrino point sources in three years o…
Prospects for quarkonium studies at the high-luminosity LHC
2020
Prospects for quarkonium-production studies accessible during the upcoming high-luminosity phases of the CERN Large Hadron Collider operation after 2021 are reviewed. Current experimental and theoretical open issues in the field are assessed together with the potential for future studies in quarkonium-related physics. This will be possible through the exploitation of the huge data samples to be collected in proton-proton, proton-nucleus and nucleus-nucleus collisions, both in the collider and fixed-target modes. Such investigations include, among others, those of: (i) J/psi and Upsilon produced in association with other hard particles; (ii) chi(c,b) and eta(c,b) down to small transverse mom…
Al Rey ... sv Religion de Montesa, defendida por Frey Don Hippolyto de Samper y Gordejuela ... Con el defensor de la Iurisdicion Real de los Reynos d…
1692
Port. orlada Notes al peu Sign.: [ ]2, A-P2 (la 2a en bl.), Q2
Differential branching fraction and angular analysis of the decay $B^{0} \to K^{*0} \mu^{+}\mu^{-}$
2013
The angular distribution and differential branching fraction of the decay B-0 -> K*(0)mu(+)mu(-) are studied using a data sample, collected by the LHCb experiment in pp collisions at root s = 7 TeV, corresponding to an integrated luminosity of 1.0 fb(-1). Several angular observables are measured in bins of the dimuon invariant mass squared, q(2). A first measurement of the zero-crossing point of the forward-backward asymmetry of the dimuon system is also presented. The zero-crossing point is measured to be q(0)(2) = 4.9 +/- 0.9 GeV2/c(4), where the uncertainty is the sum of statistical and systematic uncertainties. The results are consistent with the Standard Model predictions.
Deep sea tests of a prototype of the KM3NeT digital optical module
2014
SIRE(opens in a new window)|View at Publisher| Export | Download | Add to List | More... European Physical Journal C Volume 74, Issue 9, 1 September 2014, 8p Deep sea tests of a prototype of the KM3NeT digital optical module: KM3NeT Collaboration (Article) Adrián-Martínez, S.a, Ageron, M.b, Aharonian, F.c, Aiello, S.d, Albert, A.e, Ameli, F.f, Anassontzis, E.G.g, Anghinolfi, M.h, Anton, G.i, Anvar, S.j, Ardid, M.a, de Asmundis, R.k, Balasi, K.l, Band, H.m, Barbarino, G.kn, Barbarito, E.o, Barbato, F.kn, Baret, B.p, Baron, S.p, Belias, A.lq, Berbee, E.m, van den Berg, A.M.r, Berkien, A.m, Bertin, V.b, Beurthey, S.b, van Beveren, V.m, Beverini, N.st, Biagi, S.uv, Bianucci, S.t, Billault, M.b,…
Heat-stable antigen is expressed by murine keratinocytes and delivers costimulatory signals in T-cell activation.
1995
Heat-stable antigen (HSA), expressed by various antigen-presenting cells (APC), has been described as a costimulatory molecule for CD4+ T cells. Recently, we observed that HSA also serves as an important costimulatory molecule on epidermal Langerhans cells (LC). During these studies, low levels of HSA staining were also detected on normal murine keratinocytes (KC). To investigate whether HSA also is involved in T-cell activation by KC, normal murine KC or the spontaneously transformed KC cell-line PAM 212 were treated with PDB or PMA to induce HSA-expression. FACS analyses showed induction of HSA expression on normal murine KC, as well as PAM 212 cells. In functional assays PDB or PMA-treat…