Search results for "iNOS"
showing 10 items of 2075 documents
Wicked behavior and catastrophes in the Roman world: believes, religiosity and politic
2014
La religión es un componente tan esencial en las sociedades del Mundo Antiguo que de su correcta difusión y de la perfecta realización de los cultos depende la disposición de los dioses y, con ella, el devenir de los acontecimientos. En la vida práctica, esto se transmite en dos ámbitos: la élite, el grupo encargado de la celebración de los ritos no puede cometer errores en su tarea; y el pueblo, todos los habitantes del territorio tienen que adherirse a la religión “estatal”. Cuando en alguno de estos dos elementos se producen fallos, se suceden prodigios y catástrofes de cualquier tipo. Frente a esto, la solución consiste en: castigo del causante o causantes de la impiedad y reparación de…
Modulation of Nitric Oxide Production by Tetracyclines and Chemically Modified Tetracyclines
1999
Chemically modified tetracyclines (CMTs) dose-dependently decreased inducible nitric oxide synthase (iNOS) and, consequently, nitric oxide (NO) formation by the lipopolysaccharide (LPS)-stimulated J774 line. The inhibitory effect was due to a specific reduction in the iNOS protein content in the cells, as attested by Western blot analysis and by the inhibition of iNOS mRNA accumulation. Furthermore, CMTs cause a dose-dependent increase in cell death in the J774 line mediated by the NO-independent apoptotic mechanism.
The Host Response toListeria monocytogenesMutants Defective in Genes Encoding Phospholipases C(plcA, plcB)and Actin Assembly(actA)
1997
Several genes involved in the determination of Listeria monocytogenes pathogenesis have been identified. Among them, plcA gene encodes phosphatidylinositol-specific phospholipase C (PI-PLC), plcB gene encodes a broad-range phospholipase C (PC-PLC), and actA encodes a protein contributing to actin assembly in infected cells. The interaction of L. monocytogenes wild type (LO 28) strain and two derivative mutants, plcA- (BUG 206) and actA-/plcB- (LUT 12), with macrophages and T lymphocytes was investigated in a mouse model of listeriosis. Both mutants showed evidence of attenuation. The plcA- mutant, but not the plcB- mutant, expressed an increase in susceptibility to the anti-listerial activi…
Inability of rat alveolar macrophages to recycle l-citrulline to l-arginine despite induction of argininosuccinate synthetase mRNA and protein, and i…
1998
In the present study it was tested whether rat alveolar macrophages (AMphi) convert L-citrulline to L-arginine to maintain nitric oxide (NO) synthesis under conditions of limited availability of L-arginine. Rat AMphi (0.5 x 10(6) cells/well, cultured for 20 h in the absence or presence of 1 microg/ml lipopolysaccharides, LPS), were incubated for 6 h in amino acid-free Krebs solution and nitrite accumulation was determined as a measure of NO synthesis. After culture in the absence of LPS, nitrite in the incubation media was at the detection limit, independent of the addition of L-arginine or L-citrulline. AMphi, cultured in the presence of LPS, produced about 4 nmol per 10(6) cells and 6 h n…
Reproductive Biology and Its Impact on Body Size: Comparative Analysis of Mammalian, Avian and Dinosaurian Reproduction
2011
Janis and Carrano (1992) suggested that large dinosaurs might have faced a lower risk of extinction under ecological changes than similar-sized mammals because large dinosaurs had a higher potential reproductive output than similar-sized mammals (JC hypothesis). First, we tested the assumption underlying the JC hypothesis. We therefore analysed the potential reproductive output (reflected in clutch/litter size and annual offspring number) of extant terrestrial mammals and birds (as "dinosaur analogs") and of extinct dinosaurs. With the exception of rodents, the differences in the reproductive output of similar-sized birds and mammals proposed by Janis and Carrano (1992) existed even at the …
The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
2016
Background & Aims Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers. We investigated whether the MBOAT7-TMC4 is a susceptibility locus for the development and progression of NAFLD. Methods We genotyped rs641738 in DNA collected from 3854 participants from the Dallas Heart Study (a multi-ethnic…
Role of IL-28B and inosine triphosphatase polymorphisms in efficacy and safety of Peg-Interferon and ribavirin in chronic hepatitis C compensated cir…
2013
Genetic factors can influence the outcome of antiviral therapy in chronic hepatitis C (HCV). We evaluated the role of interleukin-28B single nucleotide polymorphisms (SNPs) and inosine triphosphatase (ITPA) gene variants in HCV cirrhosis treated with Peg-Interferon and ribavirin. A prospective cohort of 233 patients with compensated cirrhosis received 1-1.5 μg/kg/week of Peg-Interferon alpha-2b plus 1000-1200 mg/day of RBV for 48 weeks. A sustained virologic response (SVR) was achieved in 27% of patients. On multivariate logistic analysis, the absence of oesophageal varices (OR 3.64 CI 95% 1.27-10.44 P = 0.016), infection with genotype 2 or 3 (OR 4.06, CI 95% 1.08-15.26, P = 0.038), C/C all…
A Brightening Coronal Loop Observed byTRACE. I. Morphology and Evolution
2000
We analyze the transient brightening of a solar coronal loop observed, at high time cadence (30 s) and spatial resolution (05 pixel size), with the Transition Region and Coronal Explorer (TRACE) in the 171 A band on 1998 June 26. The loop, located in AR 8253, is ≈1010 cm long and inclined with respect to the vertical to the solar surface. Its geometry and shape do not change significantly during the brightening, which lasts for ~2 hr and is preceded by highly dynamic events in nearby and perhaps interacting loops. The loop footpoints brighten first; after ~10 minutes, moving brightness fronts rise initially from the northern footpoint, and after another ~7 minutes from the southern one, at …
A New Low Background Laboratory in the Pyhäsalmi Mine : Towards 14C free liquid scintillator for low energy neutrino experiments
2017
A new low background laboratory in Pyhäsalmi mine in the Central Finland has been put into operation in the beginning of 2017. The laboratory operates at the depth of 1436 m (~4100 meters of water equivalent). In this paper, we present description of the laboratory’s existing facility and background conditions. In the laboratory, a series of measurements has been started where the 14C concentration is determined from several liquid scintillator samples. A dedicated setup has been designed and constructed with the aim of measuring the 14C/12C ratio smaller than 10-18 . peerReviewed