Search results for "iTED"

Modelling Photoionisations in Tautomeric DNA Nucleobase Derivatives 7H-Adenine and 7H-Guanine: Ultrafast Decay and Photostability

2021

The study of radiation effects in DNA is a multidisciplinary endeavour, connecting the physical, chemical and biological sciences. Despite being mostly filtered by the ozone layer, sunlight radiation is still expected to (photo)ionise DNA in sizeable yields, triggering an electron removal process and the formation of potentially reactive cationic species. In this manuscript, photoionisation decay channels of important DNA tautomeric derivatives, 7H-adenine and 7H-guanine, are characterised with accurate CASSCF/XMS-CASPT2 theoretical methods. These simulation techniques place the onset of ionisation for 7H-adenine and 7H-guanine on average at 8.98 and 8.43 eV, in line with recorded experimen…

Observatoire francophone des néoplasies endocriniennes multiples de type 1. Un outil du Groupe d'étude des Tumeurs Endocrines (GTE)

2007

Wermer's syndrome or Multiple Endocrine Neoplasia Type-1 (MEN1) is an autosomal dominant inherited disease, related to mutations in MEN1, an approximately 10-kb gene encoding menin, localized on chromosome 11q13. The Endocrine Tumor Group (GTE) has set up a MEN1 observatory of 1001 regularly followed MEN1 cases. This observatory aims at registering and evaluating MEN1 cases in a large cohort. Any new study on a particular unexplored aspect of the disease may be proposed by a physician to the GTE. This article describes the way to diagnose a new MEN1 case and to register it. Procedures for participating in a new study are presented. Some original results are quoted.

Early diagnosis of colorectal cancer. Diagnostic delay reduction or rather screening programs?

2006

The Hanle effect and level crossing spectroscopy in Rb vapour under strong laser excitation

2003

We measure and simulate numerically the Hanle effect and non-zero field level crossing signals in 85 Rb and 87 Rb atoms in a magnetic field at room temperature. Diode laser radiation from 4 mW cm −2 to 3. 3W cm −2 tuned to the D2 absorption line of each isotope excites atoms into all the excited-state hyperfine levels simultaneously inside the unresolved Doppler profile. Polarization fluorescence detection is used to observe dark and bright resonances, as well as non-zero field level crossing resonances, for several excitation lines. A broad spectral line excitation model is applied to analyse the measured signals. The non-linear Zeeman effect is included in the model for both ground and ex…

Cytochrome b sequences of ancient cattle and wild ox support phylogenetic complexity in the ancient and modern bovine populations.

2009

Mitochondrial DNA has been the traditional marker for the study of animal domestication, as its high mutation rate allows for the accumulation of molecular diversity within the time frame of domestic history. Additionally, it is exclusively maternally inherited and haplotypes become part of the domestic gene pool via actual capture of a female animal rather than by interbreeding with wild populations. Initial studies of British aurochs identified a haplogroup, designated P, which was found to be highly divergent from all known domestic haplotypes over the most variable portion of the D-loop. Additional analysis of a large and geographically representative sample of aurochs from northern and…

De novo 13q deletions in two patients with mild anorectal malformations as part of VATER/VACTERL and VATER/VACTERL-like association and analysis of E…

2013

Item does not contain fulltext Anorectal malformations (ARMs) comprise a broad spectrum of conditions ranging from mild anal anomalies to complex cloacal malformations. In 40-50% of cases, ARM occurs within the context of defined genetic syndromes or complex multiple congenital anomalies, such as VATER/VACTERL (vertebral defects [V], ARMs [A], cardiac defects [C], tracheoesophageal fistula with or without esophageal atresia [TE], renal malformations [R], and limb defects [L]) association. Here, we report the identification of deletions at chromosome 13q using single nucleotide polymorphism-based array analysis in two patients with mild ARM as part of VATER/VACTERL and VATER/VACTERL-like ass…

Characterizing mortality effects of particulate matter size fractions in the two capital cities of the Canary Islands

2010

Most of the studies differentiating the effect of size-classified particulate matter (PM) exposure have been carried out in cities where the average levels of fine particles (PM2.5) were higher than those of coarse particles (PM10-2.5). These studies have suggested that PM2.5 is associated with daily mortality, but there is only limited evidence that PM10-2.5 is independently associated with mortality. The citizens of the Canary Islands are exposed to PM which is highly influenced by mineral dust because of the islands' proximity to the Western Coast of Morocco. This offers an excellent opportunity to analyze in detail the short-term association between PM size fractions and total, respirat…

Selective properties of neutron transfer reactions in the 90Zr + 208Pb system for the population of excited states in zirconium isotopes

2015

Abstract Nuclei produced via multineutron transfer channels have been studied in 90 Zr + 208 Pb close to the Coulomb barrier energy in a fragment- γ coincident measurement employing the PRISMA magnetic spectrometer coupled to the CLARA γ -array. The selective properties of the reaction mechanism have been discussed in terms of states and their strength excited in the neutron transfer channels leading to 89–94 Zr isotopes. A strong population of yrast states, with energies up to ∼7.5 MeV has been observed.

Ethnicity and hepatitis C virus infection.

2004

Pharmacokinetic properties of recombinant FVIIa in inherited FVII deficiency account for a large volume of distribution at steady state and a prolong…

2014

Pharmacokinetic properties of recombinant FVIIa in inherited FVII deficiency account for a large volume of distribution at steady state and a prolonged pharmacodynamic effect -