Search results for "iban"
showing 10 items of 133 documents
Copper quality and sources in Middle Bronze Age I Byblos and Tell Arqa (Lebanon)
2013
Abstract Forty-four Middle Bronze Age I weapons discovered at the sites of Byblos and Tell Arqa in Lebanon were investigated in order to study their copper quality and provenance. The evaluation of copper qualities is based on quantifying permanent inclusions such as copper sulfide and lead globules. The provenance of copper was studied using lead isotope analyses. For further discrimination between copper groups and sources elemental analyses by PIXE were performed on some of the weapons investigated. The results revealed two copper groups that could be qualified as “dirty” copper and “clean” copper. The former was used in most of the weapon types whereas the latter was reserved for items …
Modelling prey-predator interactions in Messina beachrock pools
2020
Abstract The Strait of Messina (Sicily, Italy) attracts the interest of marine ecologists for the presence of a large variety of habitat and mutually-interacting communities. Among them, beachrock formations, despite their wide geographic distribution, which also includes the Mediterranean area, have been poorly investigated from the biotic viewpoint. In this paper, the spatial and seasonal variability of benthic megafauna from the Messina microtidal beachrock is described. Combining in situ collected data (measurements of abiotic parameters and underwater visual census) with theoretical post-processing analyses (analysis of similarity percentages and cluster analysis), we deduced the possi…
Management of patients with hereditary angioedema in Germany: comparison with other countries in the Icatibant Outcome Survey
2018
Abstract Background The Icatibant Outcome Survey (IOS; NCT01034969) is a Shire‐sponsored, international, observational study monitoring the safety and effectiveness of icatibant, a bradykinin B2 receptor antagonist approved for the acute treatment of adults with hereditary angioedema with C1 inhibitor deficiency (HAE‐C1‐INH). Objective To report IOS data comparing demographic and icatibant treatment outcomes in patients with HAE‐C1‐INH from Germany to HAE‐C1‐INH patients from 11 other IOS countries. Methods A descriptive, retrospective, comparative analysis of data from 685 IOS patients with HAE‐C1‐INH from seven centres in Germany (n = 93) vs. centres from Austria, Brazil, Czech Republic, …
Non-Radiation Based Early Pain Relief Treatment Options for Patients With Non-Small Cell Lung Cancer and Cancer Induced Bone Pain: A Systematic Review
2020
Introduction: Cancer induced bone pain (CIBP) is frequent in patients with non-small cell lung cancer (NSCLC). Radiation therapy continues to be the gold standard for treatment of painful bone metastases, however only a limited number of metastases can be irradiated. We evaluated non-radiation based early CIBP relief options in NSCLC through a systematic review. Methods: Systematic review including all prospective articles published between 01-1994 and 06-2020 on Pubmed, Cochrane Library and ClinicalTrials.gov database. Inclusion: nonradiation based trials evaluating CIBP early pain relief options (initially defined as pain score evaluated within two weeks, because of no randomized trials, …
The Burden of Respiratory Syncytial Virus Disease in Pre-Term Infants
2015
This mini-review summarises the risk factors for acquiring Respiratory Syncitial Virus (RSV) infection, and describes the harmful effects of the infection in pre-term infants. Moreover, theoretical considerations are discussed for the prevention of RSV infection in high-risk infant categories, such as pre-term infants. Background: Neonates positive for RSV are more prone to severe infection than neonates infected with other common respiratory viruses. Despite RSV infection being more common in late neonates than in early ones, pre-term infants ≤ 35 wk gestational age (GA) are at high risk for developing severe RSV disease. Efforts to prevent infection include case management, vaccination an…
Treatment of acute edema attacks in hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant)
2006
Background In hereditary angioedema, bradykinin is assumed to be the most important mediator of edema formation. Objective To assess whether the selective bradykinin receptor-2 antagonist Icatibant is effective in acute edema attacks of hereditary angioedema. Methods In this uncontrolled pilot study, 15 patients with 20 attacks were treated with Icatibant. The attacks were analyzed by using a standardized and validated visual analog scale measurement and compared with historical data of untreated attacks. Plasma bradykinin concentration was measured before and 4 hours after intravenous Icatibant treatment. Results Symptom intensity decreased within 4 hours after administration of Icatibant;…
Hereditary angioedema in children and adolescents - A consensus update on therapeutic strategies for German-speaking countries.
2020
Background/methods At a consensus meeting in August 2018, pediatricians and dermatologists from German-speaking countries discussed the therapeutic strategy for the treatment of pediatric patients with type I and II hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH) for Germany, Austria, and Switzerland, taking into account the current marketing approval status. HAE-C1-INH is a rare disease that usually presents during childhood or adolescence with intermittent episodes of potentially life-threatening angioedema. Diagnosis as early as possible and an optimal management of the disease are important to avoid ineffective therapies and to properly treat swelling attacks. This art…
Phytochemical and pharmacological properties of essential oils from Cedrus species
2017
Natural products frequently exert pharmacological activities. The present review gives an overview of the ethnobotany, phytochemistry and pharmacology of the Cedrus genus, e.g. cytotoxic, spasmolytic immunomodulatory, antiallergic, anti-inflammatory and analgesic activities. Cancer patients frequently seek remedies from traditional medicinal plants that are believed to exert less side effects than conventional therapy with synthetic drugs. A long-lasting goal of anti-cancer and anti-microbial therapy research is to find compounds with reduced side effects compared to currently approved drugs. In this respect, Cedrus species might be of interest. The essential oil isolated from Cedrus libani…
Sobre cerámicas Helenísticas en Iberia / Hispania. Significado y funcionalidad
2012
In this work we are going to take a chronological and typological tour by studying the iconography that appears in the Hellenistic wares imported from the Central and Oriental Mediterranean between 3rd and 2nd centuries BC in Hispania Citerior, in particular from Cartagena. We are going to analyze its functionality in the places of origin, and with the help of the Hispanic contexts we will conclude whether its presence here is a consequence of a certain commercial dynamic, or if it answers to a decorative preference, of taste or trend; even if the images are significant related to ritual or convivial uses, public or private, by the local inhabitant who acquires and uses them.
Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets.
2006
Platelet activation causes conformational changes of integrin GPIIb/IIIa (α IIb β 3 ), resulting in the exposure of its ligand-binding pocket. This provides the unique possibility to design agents that specifically block activated platelets only. We used phage display of single-chain antibody (scFv) libraries in combination with several rounds of depletion/selection to obtain human scFvs that bind specifically to the activated conformation of GPIIb/IIIa. Functional evaluation of these scFv clones revealed that fibrinogen binding to human platelets and platelet aggregation can be effectively inhibited by activation-specific scFvs. In contrast to clinically used GPIIb/IIIa blockers, which ar…