6533b7d0fe1ef96bd125aef9
RESEARCH PRODUCT
Phytochemical and pharmacological properties of essential oils from Cedrus species
Mona TannouryMassimo TacchiniAlessandra GuerriniAnake KijjoaGianni SacchettiThomas EfferthJihad AbboudRosa TundisHassane MakhloufMona Diab-assafIlaria LamprontiSamir MedawarAntoine G. El SamraniRoberto GambariAntoine M. SaabJawad Aounsubject
Antiproliferative activity; Cedrus atlantica; Cedrus deodara; Cedrus libani; essential oils; leukaemia cells; Pinaceae; Analytical Chemistry; Biochemistry; Plant Science; Organic ChemistryCedrus deodaraPhytochemicalsCedrus deodaraCedrus atlanticaAnti-Inflammatory Agentsleukaemia cellsAntiproliferative activityPlant Science01 natural sciencesBiochemistryCedruslaw.inventionNOAnalytical Chemistry03 medical and health sciences0302 clinical medicineAnti-Infective AgentslawOils VolatileHumansMedicinal plantsCedrusessential oilsEssential oilPolycyclic SesquiterpenesCedrus libaniPlants MedicinalTraditional medicinebiologyOrganic ChemistryCedrus libanibiology.organism_classificationPinaceaeAntineoplastic Agents Phytogenic0104 chemical sciencesPlant Leaves010404 medicinal & biomolecular chemistryPhytochemicalDrug development030220 oncology & carcinogenesisCedrus atlanticaSesquiterpenesdescription
Natural products frequently exert pharmacological activities. The present review gives an overview of the ethnobotany, phytochemistry and pharmacology of the Cedrus genus, e.g. cytotoxic, spasmolytic immunomodulatory, antiallergic, anti-inflammatory and analgesic activities. Cancer patients frequently seek remedies from traditional medicinal plants that are believed to exert less side effects than conventional therapy with synthetic drugs. A long-lasting goal of anti-cancer and anti-microbial therapy research is to find compounds with reduced side effects compared to currently approved drugs. In this respect, Cedrus species might be of interest. The essential oil isolated from Cedrus libani leaves may bear potential for drug development due to its high concentrations of germacrene D and β-caryophyllene. The essential oils from Cedrus species also show bioactivity against bacteria and viruses. More preclinical analyses (e.g. in vivo experiments) as well as clinical trials are required to evaluate the potential of essential oils from Cedrus species for drug development.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-07-04 |