0000000000125129

AUTHOR

Antoine M. Saab

showing 5 related works from this author

Phytochemical and pharmacological properties of essential oils from Cedrus species

2017

Natural products frequently exert pharmacological activities. The present review gives an overview of the ethnobotany, phytochemistry and pharmacology of the Cedrus genus, e.g. cytotoxic, spasmolytic immunomodulatory, antiallergic, anti-inflammatory and analgesic activities. Cancer patients frequently seek remedies from traditional medicinal plants that are believed to exert less side effects than conventional therapy with synthetic drugs. A long-lasting goal of anti-cancer and anti-microbial therapy research is to find compounds with reduced side effects compared to currently approved drugs. In this respect, Cedrus species might be of interest. The essential oil isolated from Cedrus libani…

Antiproliferative activity; Cedrus atlantica; Cedrus deodara; Cedrus libani; essential oils; leukaemia cells; Pinaceae; Analytical Chemistry; Biochemistry; Plant Science; Organic ChemistryCedrus deodaraPhytochemicalsCedrus deodaraCedrus atlanticaAnti-Inflammatory Agentsleukaemia cellsAntiproliferative activityPlant Science01 natural sciencesBiochemistryCedruslaw.inventionNOAnalytical Chemistry03 medical and health sciences0302 clinical medicineAnti-Infective AgentslawOils VolatileHumansMedicinal plantsCedrusessential oilsEssential oilPolycyclic SesquiterpenesCedrus libaniPlants MedicinalTraditional medicinebiologyOrganic ChemistryCedrus libanibiology.organism_classificationPinaceaeAntineoplastic Agents Phytogenic0104 chemical sciencesPlant Leaves010404 medicinal & biomolecular chemistryPhytochemicalDrug development030220 oncology & carcinogenesisCedrus atlanticaSesquiterpenes
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Phytochemical Analysis and Cytotoxicity Towards Multidrug-Resistant Leukemia Cells of Essential Oils Derived from Lebanese Medicinal Plants

2012

Juniperus excelsa fruit essential oil as well as J. oxycedrus, Cedrus libani, and Pinus pinea wood essential oils have been obtained with yields between 2.2 ± 0.3 % to 3.4 ± 0.5 % and analyzed by gas chromatography. Sesquiterpenes mainly characterized C. libani and J. oxycedrus essential oils, while in P. pinea and J. excelsa, monoterpenes were the most abundant compounds. In J. oxycedrus, cis-calamenene (7.8 %), cuparene (3.8 %), and cis-thujopsenal (2.0 %) have been detected for the first time. The cytotoxic activity of these essential oils against drug-sensitive CCRF-CEM and multidrug-resistant P-glycoprotein-expressing CEM/ADR5000 leukemia cells has been investigated (IC₅₀ values: 29.46…

Cupressaceaegas chromatographyPharmaceutical ScienceAnalytical Chemistrylaw.inventionlawDrug DiscoveryTumor Cells CulturedLebanonMedicinal plantsLeukemiabiologyTraditional medicinePinaceaeWoodDrug Resistance MultiplePhytochemicalJuniperus excelsaPinaceaeMolecular MedicineSesquiterpenesJuniperus oxycedruscancer; essential oils; gas chromatography; multidrug resistance; Juniperus excelsa; Juniperus oxycedrus; Cupressaceae; Cedrus libani; Pinus pinea; PinaceaeNOmultidrug resistanceBotanyOils VolatileHumanscancerCedrusessential oilsEssential oilCedrus libaniPharmacologyPlants MedicinalOrganic ChemistryCupressaceaePinusbiology.organism_classificationCedrus libaniAntineoplastic Agents PhytogenicComplementary and alternative medicineDrug Resistance NeoplasmFruitJuniperusMonoterpenesPinus pineaJuniperus excelsaJuniperus oxycedrusPhytotherapyPlanta Medica
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Laurus nobilis L. Seed Extract Reveals Collateral Sensitivity in Multidrug-Resistant P-Glycoprotein-Expressing Tumor Cells.

2015

The frequent failure of standard cancer chemotherapy requires the development of novel drugs capable of killing otherwise drug-resistant tumors. Here, we have investigated a chloroform extract of Laurus nobilis seeds. Fatty acids and 23 constituents of the volatile fraction were identified by gas chromotography/flame ionization detection (GC/FID) and gas chromatography/mass spectrometry (GC/MS), in good agreement with (1)H NMR (nuclear magnetic resonance) spectrum. Multidrug-resistant P-glycoprotein-expressing CEM/ADR5000 leukemia cells were hypersensitive (collaterally sensitive) toward this extract compared to drug-sensitive CCRF-CEM cells, whereas CEM/ADR5000 cells were 2586-fold resista…

Cancer ResearchATP Binding Cassette Transporter Subfamily BCell SurvivalABC transporter Cancer Lauraceae Multidrug resistance Oncobiogram SpiceMedicine (miscellaneous)Multidrug resistanceLaurusGas Chromatography-Mass SpectrometryFlow cytometryNOchemistry.chemical_compoundLauraceaeLaurus nobilisfoodCell Line TumormedicineHumansDoxorubicinP-glycoproteinCancerNutrition and DieteticsChromatographyLeukemiabiologymedicine.diagnostic_testChemistryPlant ExtractsOncobiogramMolecular biologyAntineoplastic Agents Phytogenicfood.foodMultiple drug resistanceOleic acidSpiceEucalyptolOncologyCell cultureDoxorubicinDrug Resistance NeoplasmSeedsbiology.proteinABC transportermedicine.drugNutrition and cancer
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Biopiracy of natural products and good bioprospecting practice

2016

Made available in DSpace on 2018-11-26T16:27:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-02-15 Deutsche Forschungsgemeinschaft Background: Biopiracy mainly focuses on the use of biological resources and/or knowledge of indigenous tribes or communities without allowing them to share the revenues generated out of economic exploitation or other non-monetary incentives associated with the resource/knowledge. Methods: Based on collaborations of scientists from five continents, we have created a communication platform to discuss not only scientific topics, but also more general issues with social relevance. This platform was termed 'PhytCancer -Phytotherapy to Fight Cancer' (www.phy…

0301 basic medicineResource (biology)Drug IndustryInternational CooperationTheftPharmaceutical ScienceIntellectual property0603 philosophy ethics and religionIndigenousPatents as Topic03 medical and health sciencesIndigenous knowledgeDrug DiscoveryPatents as TopicTraditional knowledgeDeveloping CountriesPharmacologyBioprospectingBiological ProductsBioprospectingPlants Medicinalbusiness.industryIntellectual propertyCommercializationOwnership06 humanities and the artsPublic relationsBioethicsNatural resource030104 developmental biologyIncentiveComplementary and alternative medicineEthnopharmacologyMolecular MedicinePatent060301 applied ethicsBusiness
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Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells

2019

Abstract Background Cucurbitacin E (CuE) is an oxygenated tetracyclic triterpenoid isolated from the fruits of Citrullus colocynthis (L.) Schrad. Purpose This study outlines CuE's cytotoxic activity against drug-resistant tumor cell lines. Three members of ABC transporters superfamily, P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and ABCB5 were investigated, whose overexpression in tumors is tightly linked to multidrug resistance. Further factors of drug resistance studied were the tumor suppressor TP53 and the epidermal growth factor receptor (EGFR). Methods Cytotoxicity assays (resazurin assays) were used to investigate the activity of Citrullus colocynthis and CuE towar…

Abcg2Drug ResistancePharmaceutical ScienceATP-binding cassette transporterMicroarraySubfamily Gchemistry.chemical_compoundGene Knockout Techniques0302 clinical medicineEpidermal growth factorPhytogenicDrug DiscoveryATP Binding Cassette Transporter Subfamily G Member 2Cancer0303 health sciencesTumorLeukemiabiologyChemistryABCB5TransfectionCell cycleNeoplasm ProteinsGene Expression Regulation NeoplasticErbB ReceptorsMolecular Docking SimulationSubfamily B030220 oncology & carcinogenesisMolecular MedicineCitrullus colocynthiMember 2Member 1ATP Binding Cassette Transporter Subfamily BATP Binding Cassette TransporterAntineoplastic AgentsCell Line03 medical and health sciencesCell Line TumorHumansATP Binding Cassette Transporter Subfamily B Member 1030304 developmental biologyCucurbitacin EPharmacologyNeoplasticTraditional herbal medicineCancer; Citrullus colocynthis; Drug resistance; Microarray; Traditional herbal medicine; ATP Binding Cassette Transporter Subfamily B; ATP Binding Cassette Transporter Subfamily B Member 1; ATP Binding Cassette Transporter Subfamily G Member 2; Antineoplastic Agents Phytogenic; Cell Line Tumor; Citrullus colocynthis; Doxorubicin; Drug Resistance Neoplasm; ErbB Receptors; Gene Expression Regulation Neoplastic; Gene Knockout Techniques; Humans; Leukemia; Molecular Docking Simulation; Neoplasm Proteins; Triterpenes; Tumor Suppressor Protein p53Antineoplastic Agents PhytogenicTriterpenesComplementary and alternative medicineGene Expression RegulationDrug Resistance NeoplasmDoxorubicinCancer cellbiology.proteinCancer researchNeoplasmCitrullus colocynthisTumor Suppressor Protein p53
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