Phytochemical Analysis and Cytotoxicity Towards Multidrug-Resistant Leukemia Cells of Essential Oils Derived from Lebanese Medicinal Plants

6533b82efe1ef96bd1293c76

RESEARCH PRODUCT

Phytochemical Analysis and Cytotoxicity Towards Multidrug-Resistant Leukemia Cells of Essential Oils Derived from Lebanese Medicinal Plants

Thomas Efferth Antoine M. Saab Alessandra Guerrini Silvia Maietti Joachim Arend Gianni Sacchetti Maʼen Zeino Roberto Gambari Francesco Bernardi

subject

Cupressaceae gas chromatography Pharmaceutical Science Analytical Chemistry law.invention law Drug Discovery Tumor Cells Cultured Lebanon Medicinal plants Leukemia biology Traditional medicine Pinaceae Wood Drug Resistance Multiple Phytochemical Juniperus excelsa Pinaceae Molecular Medicine Sesquiterpenes Juniperus oxycedrus cancer; essential oils; gas chromatography; multidrug resistance; Juniperus excelsa; Juniperus oxycedrus; Cupressaceae; Cedrus libani; Pinus pinea; Pinaceae NO multidrug resistance Botany Oils Volatile Humans cancer Cedrus essential oils Essential oil Cedrus libani Pharmacology Plants Medicinal Organic Chemistry Cupressaceae Pinus biology.organism_classification Cedrus libani Antineoplastic Agents Phytogenic Complementary and alternative medicine Drug Resistance Neoplasm Fruit Juniperus Monoterpenes Pinus pinea Juniperus excelsa Juniperus oxycedrus Phytotherapy

description

Juniperus excelsa fruit essential oil as well as J. oxycedrus, Cedrus libani, and Pinus pinea wood essential oils have been obtained with yields between 2.2 ± 0.3 % to 3.4 ± 0.5 % and analyzed by gas chromatography. Sesquiterpenes mainly characterized C. libani and J. oxycedrus essential oils, while in P. pinea and J. excelsa, monoterpenes were the most abundant compounds. In J. oxycedrus, cis-calamenene (7.8 %), cuparene (3.8 %), and cis-thujopsenal (2.0 %) have been detected for the first time. The cytotoxic activity of these essential oils against drug-sensitive CCRF-CEM and multidrug-resistant P-glycoprotein-expressing CEM/ADR5000 leukemia cells has been investigated (IC₅₀ values: 29.46 to 61.54 µg/mL). Remarkably, multidrug-resistant CEM/ADR5000 cells did not reveal cross-resistance, indicating that these essential oils might be useful to treat otherwise drug-resistant and refractory tumors.

year	journal	country	edition	language
2012-11-15	Planta Medica

https://doi.org/10.1055/s-0032-1327896

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