Search results for "ibi"

Taste receptors in oral and extraoral tissues: role in nutrient and metabolic sensing

2014

The synergistic effect exerted by the HDAC inhibitor SAHA and the sesquiterpene lactone parthenolide on triple negative breast canc er cells

2014

Triple-negative breast cancer (TNBC) is a subtype o f breast cancer, insensitive to endocrine therapy. Chemotherapy is the main form of treatment, but is accompanied by a high rate of recidivism. The sesquiterpene lactone Parthenolide (PN) exerts a cy totoxic effect on MDA-MB231 cells, a TNBC cell line (1), but was ineffective at low doses (2-5μM). This repr esents an obstacle for a therapeutic utilization of PN. We supposed, in line with other authors (2), that PN c auses a protective response, which at low doses pre vails on the cytotoxic effect. With the aim of inhibiting this protective effect we have shown that pre-trea tment of MDA-MB231 cells with SAHA (2-5μM), an histone deace tylat…

Utilisation d'ensembles de simulations climatiques sur Modèles de Circulation Générale de l'Atmosphère: concepts, méthodes et applications à la clima…

2003

Les séries (ensembles) de simulations longues sur modèles numériques de Circulation Générale de l'Atmosphère (MCGA) - réalisées par la communauté des physiciens de l'atmosphère – offrent au géographe climatologue plusieurs informations relatives à la variabilité du climat complétant l'analyse des séries observées. L'étude présentée ici se base sur un ensemble de 8 simulations longues (de 1948 à 1997) réalisées sur le MCGA français ARPEGE Climat - Version 3 (Centre National de Recherches Météorologiques). Ces simulations utilisent comme conditions aux limites l'énergie solaire et les champs de Températures de Surface de la Mer. Ces dernières varient en fonction des observations mensuelles et…

Sensibilité des rendements agricoles potentiels aux paramètres climatiques et environnementaux dans la région du mont Kenya en Afrique de l’Est.

2013

7 pages; International audience; Comprendre les interactions existantes entre le climat et les rendements céréaliers est un objectif important pour l'actuelleproduction agricole et la sécurité alimentaire future des populations résidant dans des régions à agriculture pluviale. Lesrendements potentiels de sorgho simulés par le modèle SARRAH montrent une sensibilité aux paramètres climatiques etenvironnementaux le long des pentes orientales du Mont Kenya. Si le cumul et la durée de saison expliquent une part importante dela variabilité des rendements, d’autres variables comme l’intensité quotidienne, les Tmax ou encore le rayonnement global jouentun rôle non négligeable. La date de semis modu…

Murine Model of Cytomegalovirus Latency and Reactivation

2008

Efficient resolution of acute cytopathogenic cytomegalovirus infection through innate and adaptive host immune mechanisms is followed by lifelong maintenance of the viral genome in host tissues in a state of replicative latency, which is interrupted by episodes of virus reactivation for transmission. The establishment of latency is the result of aeons of co-evolution of cytomegaloviruses and their respective host species. Genetic adaptation of a particular cytomegalovirus to its specific host is reflected by private gene families not found in other members of the cytomegalovirus group, whereas basic functions of the viral replicative cycle are encoded by public gene families shared between …

Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor

2002

Ciliary neurotrophic factor (CNTF) displays neurotrophic activities on motor neurons and neural cell populations both in vivo and in vitro. On target cells lacking intrinsic expression of specific receptor alpha subunits cytokines of the IL-6 family only act in the presence of their specific agonistic soluble receptors. Here, we report the construction and expression of a CNTF/soluble CNTF-receptor (sCNTF-R) fusion protein (Hyper-CNTF) with enhanced biological activity on cells expressing gp130 and leukemia inhibitory factor receptor (LIF-R), but not membrane-bound CNTF-R. At the cDNA level, the C-terminus of the extracellular domain of human CNTF-R (amino acids 1-346) was linked via a sing…

P3‐039: Axonal neuritic pathology induces early presynaptic alterations in ps1/APP Alzheimer's mice hippocampus

2011

Loss of neurons in the hippocampus correlates with memory impairment in AD. Significant early reduction in the numerical density of hippocampal SOM interneurons was found in single (APPswe) and double (APPswe/ PS1dE9 and APPswe/TauP301S-G272V) transgenic models based on APP over expression and amyloid production. However, this inhibitory population was unaffected in age-matched single PS1 and tau transgenic mice as well as nontransgenic controls. Whereas SOM neuron loss in APPswe/PS1dE9 was associated to the onset of extracellular amyloid pathology in double APP/ tau mice this loss preceded plaque formation. Conclusions: As in human AD, somatostatin cell loss is a common early pathological …

Mapping Sediment Accumulation Rate by using Volume magnetic Susceptibility Core Correlation in a contaminated Bay (Lake Geneva, Switzerland)

2003

The Bay of Vidy is the most contaminated area of Lake Geneva: contamination is caused by the effluent of the sewage treatment plant (STP) of the City of Lausanne. The implementation of a chemical stage in the treatment plant to remove phosphorus using FeC13 in 1971 is indirectly recorded in the lake sediments by a strong and sharp increase in the volume magnetic susceptibility (VMS) signal. A total of 43 sediment cores have been retrieved and measured for VMS. The synchronism of the VMS signal increase and its relation to the implementation of the P-removal stage in the STP has been shown in seven 137Cs-dated sediment cores. The VMS signal has been used to date by stratigraphie correlation …

Unusual business or business as usual: An investigation of meeting support requirements in multilateral diplomacy

1993

Abstract The concept of supporting meetings at the same time and at the same place with computers raises the problem of how salient features of group behaviors are understood in meetings. In this paper we critically examine some aspects of meeting behaviors. We point out that the idea of small, cohesive business teams is not necessarily a valid starting point in thinking of all meeting support. In particular, beliefs that relate to user aspects, group features such as composition, structure and protocols, and task characteristics such as nature, importance, and goals in meetings may need deliberation in many group decision support systems (GDSS) interventions. To demonstrate the credibility…

Magnetic coupling and spin topology in linear oxalato-bridged tetranuclear chromium(III)–copper(II) complexes with aromatic diimine ligands

2013

Abstract A novel heterotetranuclear chromium(III)–copper(II) complex of formula {[CrIII(bpy)(ox)2]2CuII2(bpy)2(ox)}·6H2O (1) has been synthesized by the ligand exchange reaction between Ph4P[CrIII(bpy)(ox)2]·H2O and [CuII(bpy)2(NO3)]NO3·MeOH in methanol (bpy = 2,2′-bipyridine; ox2− = oxalate dianion). The X-ray crystal structure of 1 consists of neutral oxalato-bridged CrIII2Cu2II zigzag entities which are formed by the monodentate coordination of two [CrIII(bpy)(ox)2]− mononuclear anionic units through one of its two oxalato groups toward a [CuII2(bpy)2(ox)]2+ dinuclear cationic moiety featuring relatively long axial bonds at the square pyramidal CuII ions. Variable temperature (2.0–300 K)…