Search results for "imbalance"

NEUROINFLAMMATION AND SYNAPTIC IMBALANCE IN ALZHEIMER’S DISEASE

2020

From gut microflora imbalance to mycobacteria infection: is there a relationship with chronic intestinal inflammatory diseases?

2011

The gut of a healthy adult harbours a myriad of different microbial species. It is estimated that approximately 10 14 are present in total bacterial colony forming units (CFU). Each colony colonizes a specific intestinal tract. In healthy adult, the main control of intestinal bacterial colonization occurs through gastric acidity but also other factors can influence the intestinal microenvironment such as pH, temperature, competition among different bacterial strains, peristalsis, drugs, radiotherapy and much more. Impaired microbial homeostasis leads to an alteration of the permeability of tissue, together with the activation of the intestinal immune system MALT (mucosal associated lymphoid…

Labor Market Imbalances and Personnel Recruitment

2019

When the economy of a country starts to expand or collapse in wealth, it is reflected in the labor market with an impact on employment and personnel recruitment processes. The aim of this article is to investigate the relationship between personnel recruitment and job market imbalances in the various de- velopmental conditions of the macroeconomic environment. Research find- ings show that employers tend to adopt more active, formal, competitive, targeted, and selective search behaviors in the positive cycles of the economy and employment. Conversely, in downturns of the economy and employ- ment, employers tend to be more passive and defensive, relying on informal relationships and, in some…

Measuring job stress in transportation workers: psychometric properties, convergent validity and reliability of the ERI and JCQ among professional dr…

2021

Abstract Background The accumulated evidence has shown how professional drivers are, in psychosocial terms, among the most vulnerable workforces, and how their crashes (some of them preceded by stressful working conditions) constitute both an occupational and public health concern. However, there is a clear lack of validated tools for measuring stress and other key hazardous issues affecting transport workers, and most of the existing ones, frequently generic, do not fully consider the specific features that properly describe the work environment of professional driving. This study assessed the psychometric properties, convergent validity and consistency of two measures used for researching…

Differential haplotypic expression of the interleukin-18 gene

2007

Interleukin 18 (IL-18) is suspected to play an important role in atherosclerosis and plaque vulnerability. We had previously shown that haplotypes combining two IL18 gene polymorphisms in complete linkage disequilibrium, C-105T (rs360717) in 5'-untranslated region (UTR) and A+183G (rs5744292) in 3'-UTR, were related to IL-18 circulating levels and cardiovascular outcome, the C(-105) G(+183) haplotype being associated with lower IL-18 levels and lower cardiovascular risk. This study was aimed at investigating the functional role of the two polymorphisms and their haplotypes on IL18 expression levels. Allelic imbalance experiments conducted in 24 and 20 subjects heterozygous for the C-105T an…

How BATNAs perception impacts JVs negotiations

2013

PurposeIn light of the inconclusive findings in literature, the aim of this paper is to answer the question: how can negotiation behavior be explained in a situation of power imbalance?Design/methodology/approachBased on Kim et al., the paper proposes a theoretical model that is empirically studied through a case study.FindingsPower relationship is a key contextual factor in determining negotiation behavior in joint ventures (JVs), but it has to be defined more in terms of the perceived value of the alternatives rather than the amount of available better alternatives to a negotiation agreement (BATNAs). Thus, when a partner looks to gain access to knowledge (market, technology, etc.) about …

The European sovereign debt market: from integration to segmentation

2013

This paper investigates the impact of European Monetary Union (EMU) and of the recent financial and fiscal crisis on the integration of the European sovereign debt market using annual data 1992–2010. The panel regression dependent variable is time-varying market linkages computed from daily realised correlations between sovereign bond returns for 13 European economies and Germany. The results indicate that the elimination of currency risk following the implementation of EMU led to a fundamental and significant one-off increase in integration. The net impact of fiscal fundamentals was negligible up until 2009 as the markets seemed to be pricing in a potential bailout for member states in cri…

Contribution to the research of microbial and RedOx bio-indicators for the early characterisation of wood diseases in grapevines

2022

Grapevine trunk diseases, linked to pathogenic fungi whose mechanism of action is still poorly characterised, are responsible for grapevine decline in vineyards throughout the world, causing significant losses in productivity and yield in the wine sector. Given the current lack of effective solutions to stop the establishment of the disease and the development of symptoms, which are irreversible but often late in relation to the pathogenic infection, early diagnosis of these diseases is essential. Considering the grapevine holobiont, i.e. the grapevine and the microbiota interacting with, we hypothesise that early bio-indicators of diseases would make it possible to identify a disturbance i…

Holes in the Dike: The Global Savings Glut, U.S. House Prices and the Long Shadow of Banking Deregulation

2016

We explore empirically how capital inflows into the US and financial deregulation within the United States interacted in driving the run-up (and subsequent decline) in US housing prices over the period 1990-2010. To obtain an ex ante measure of financial liberalization, we focus on the history of interstate-banking deregulation during the 1980s, i.e. prior to the large net capital inflows into the US from China and other emerging economies. Our results suggest a long shadow of deregulation: in states that opened their banking markets to out-of-state banks earlier, house prices were more sensitive to capital inflows. We provide evidence that global imbalances were a major positive funding sh…

Growing Like Germany: Local Public Debt, Local Banks, Low Private Investment

2021

The paper uses a panel of more than 1m German firms over 2010-2016, to provide the first firm-bank level evidence of local crowding out for a developed economy characterized by low interest rates and fiscal austerity. Our mechanism relies on two structural features of Germany's banking landscape: the local segmentation of credit markets for small and medium-sized firms (SME) and the role of local public banks in local public finance. Local public banks dominate lending to small and medium firms in Germany and also have an explicit mandate to lend to the local public sector. With spreads on local government debt at all-time lows, local public banks tried to break even, using their market pow…