Search results for "induced"
showing 10 items of 1287 documents
EFFECT OF THE IMPase INHIBITOR L690,330 ON SEA URCHIN DEVELOPMENT
1998
Abstract A variety of concentrations of the IMPase inhibitor L690,330 were added to sea urchin embryos. Immediate arrest of development was obtained for concentrations from 7.5 m m on. Concentrations lower than 3.5 m m permitted gastrulation but inhibited skeletogenesis and disturbed elongation along the animal–vegetal axis. The latter results are similar to those obtained by counteracting lithium effect with myoinositol, which are suggested to be due to partial relief of IMPase inhibition.
Defining the genomic signature of totipotency and pluripotency during early human development.
2013
The genetic mechanisms governing human pre-implantation embryo development and the in vitro counterparts, human embryonic stem cells (hESCs), still remain incomplete. Previous global genome studies demonstrated that totipotent blastomeres from day-3 human embryos and pluripotent inner cell masses (ICMs) from blastocysts, display unique and differing transcriptomes. Nevertheless, comparative gene expression analysis has revealed that no significant differences exist between hESCs derived from blastomeres versus those obtained from ICMs, suggesting that pluripotent hESCs involve a new developmental progression. To understand early human stages evolution, we developed an undifferentiation netw…
Paper 6: EUROCAT member registries: organization and activities.
2011
BACKGROUND: EUROCAT is a network of population-based congenital anomaly registries providing standardized epidemiologic information on congenital anomalies in Europe. There are three types of EUROCAT membership: full, associate, or affiliate. Full member registries send individual records of all congenital anomalies covered by their region. Associate members transmit aggregate case counts for each EUROCAT anomaly subgroup by year and by type of birth. This article describes the organization and activities of each of the current 29 full member and 6 associate member registries of EUROCAT. METHODS: Each registry description provides information on the history and funding of the registry, popu…
Mixing dynamics in uncovered unbaffled stirred tanks
2014
Abstract The present work is aimed at providing experimental information on mixing rates in an unbaffled vessel under free surface vortexing conditions. The planar laser induced fluorescence (PLIF) technique was used for measuring the dispersion dynamics of a passive tracer over a vertical section of the vessel. In agreement with the quite scant literature information available for these systems, results confirm the existence of two well defined, partially segregated, zones that give rise to a double mixing dynamics behavior. A suitable mixing time definition is proposed and applied to a number of experimental runs with different stirrer geometries and agitation speeds. Results confirm that…
On Thermoeconomic Diagnosis of a Fouled Direct Expansion Coil: Effects of Induced Malfunctions on Quantitative Performance of the Diagnostic Technique
2017
Thermoeconomic diagnosis represents a promising technique for the detection of common faults in refrigeration systems, which are responsible of degradation in their energetic performance. Recently, the authors have carried out a sensitivity analysis of the performance of this method to the thermodynamic conditions of inlet air and to the geometry of the direct expansion coil, in case of degradation induced by evaporator fouling. The analysis showed that the method is able to detect this fault, but sometimes its quantitative assessments are not satisfactory. In order to understand more in-depth the origin of such results and identify margins for refinement of the technique, this paper is aim…
Journeys from quantum optics to quantum technology
2017
Sir Peter Knight is a pioneer in quantum optics which has now grown to an important branch of modern physics to study the foundations and applications of quantum physics. He is leading an effort to develop new technologies from quantum mechanics. In this collection of essays, we recall the time we were working with him as a postdoc or a PhD student and look at how the time with him has influenced our research.
On the induced drag reduction due to propeller-wing interaction
1995
AbstractThe aerodynamic interaction between a wing and a couple of propellers in tractor configuration is investigated by means of a model based on the lifting line concept and under the assumption of quasi-steady incompressible motion of inviscid fluid. The ways the propellers influence the wing performances, particularly the induced drag, are analysed. It turns out that the lift increase and the possible drag reduction depend strongly on the direction of the blade rotation and on the propeller distances from midspan, and result from two main effects: the direct propeller induction on the wing and the modification of the lift distribution along the span. An additional nonlinear (mixed) con…
Spatial pattern analysis using hybrid models: an application to the Hellenic seismicity
2016
Earthquakes are one of the most destructive natural disasters and the spatial distribution of their epi- centres generally shows diverse interaction structures at different spatial scales. In this paper, we use a multi-scale point pattern model to describe the main seismicity in the Hellenic area over the last 10 years. We analyze the interaction between events and the relationship with geo- logical information of the study area, using hybrid models as proposed by Baddeley et al. ( 2013 ). In our analysis, we find two competing suitable hybrid models, one with a full parametric structure and the other one based on nonpara- metric kernel estimators for the spatial inhomogeneity.
High-pressure structural and elastic properties of Tl2O3
2014
The structural properties of Thallium (III) oxide (Tl2O3) have been studied both experimentally and theoretically under compression at room temperature. X-ray powder diffraction measurements up to 37.7 GPa have been complemented with ab initio total-energy calculations. The equation of state of Tl2O3 has been determined and compared to related compounds. It has been found experimentally that Tl2O3 remains in its initial cubic bixbyite-type structure up to 22.0 GPa. At this pressure, the onset of amorphization is observed, being the sample fully amorphous at 25.2 GPa. The sample retains the amorphous state after pressure release. To understand the pressure-induced amorphization process, we h…
Novel Biocompatible Cationic Copolymers Based on Polyaspartylhydrazide Being Potent as Gene Vector on Tumor Cells
2007
Introduction. The reaction between !,"-poly(aspartylhydrazide) (PAHy), a water soluble synthetic polymer and 3-(carboxypropyl)trimethyl-ammonium chloride (CPTACl) produced copolymers bearing permanent positive charges (PAHy–CPTA) with molecular weight of 10 kDa and PAHy–CPTA copolymers differing in positive charge amount (18–58%) were chosen for biological investigations. Materials and methods. Biophysical properties of DNA/PAHy–CPTA polyplexes were evaluated in terms of DNA condensation, zeta potential and size distribution. Cytotoxicity studies on Neuro2A murine neuroblastoma cells evidenced absence of toxicity of these copolymers up to 300 2g/ml unlike linear polyethylenimine (LPEI) that…