Search results for "informatics"
showing 10 items of 2542 documents
Towards Ethical Guidelines of Using Telepresence Robots in Residential Care
2021
AbstractRobotic telepresence is a potential technology to help alleviating the loneliness of elderly people. The impacts of long-term use of telepresence robots in residential care are not well known. We were interested in how using a telepresence robot influences the resident, family members and care workers at a facility, and what challenges and solutions there are for wider adoption of such robots in residential care. With a telepresence robot Double, we arranged a series of three trials in two separate residential care facilities: one 12-week trial in a private facility and two successive 6-week trials in a public facility. In each trial, we installed the telepresence robot in a room of…
Exploring heterogeneous ICT use among older adults: The warm experts’ perspective
2020
In this article, we (1) examine the various forms of support required by older users (75+) of digital technology and (2) provide a concrete, everyday life rationale for why warm experts play such a pivotal role in the processes of adopting and using ICT. Although warm experts are usually not older adults themselves, they provide an important mediating view on the technology use among older people that has not been rigorously addressed in previous studies. Thus, in our analysis we examine the younger family members’ views on acting as warm experts to their older family members. The research data consist of 22 extended group interviews (EGI) and observation carried out in Finland. Based on ou…
Methodological advances in the functional profiling of genomic studies
2013
In this thesis we present bioinformatic tools and algorithms for the analysis of genomic data such as those generated by microarray devices or next generation sequencing techniques. Particularly, we develop new approaches to gene set analysis. The described procedures should be useful in practice to tackle complex biological experiments, but hopefully will also be methodologically relevant, as they introduce new ways of conceptualizing genomic functional profiling. Our very flexible approach allows for the inclusion of not just one kind of genomic measurement but many. It makes possible, for instance, to analyze expression measurement and genomic variation data at a time. This multidimensio…
Visual Health Nanocomposites: Present and Future
2021
Background: In recent years, the therapeutics for eye diseases as retinopathy diabetic, dry eye, glaucoma and contact lenses fabrication are including nanocompounds as ocular drug delivery systems, biomarkers for detection of eye diseases, copper and silver ions that has been incorporated by means of the nanotechnology for the production of less toxic and more effective alternatives. Several compounds such as silver nanoparticles, turmeric-based nanocomposites, neovascularization blockers and nanoparticles extracted from the plant Costus pictus among others have been researched for this purpose. Those compounds are some of the promising research efforts that are studying and will contribute…
Evolutionary systems biology of the Mycobacterium tuberculosis complex
2019
Tesis doctoral, 214 páginas
Cell Therapy in Type 1 Diabetes
2011
The incidence of diabetes mellitus has grown exponentially in the last few years. Etiopathogenesis of diabetes implies a ?-cells damage in the islet of Langerhans, either through an autoimmune reaction present in type 1 diabetic patients or through altered function within these cells that affect their ability to secrete a properly functioning insulin hormone, in patients suffering from type 2 diabetes. Exogenous insulin supply is, at the moment, the therapy of choice of the disease but it does not allow tight control of glucose regulation, leading to long-term complications. Over the past few decades, pancreas or pancreas-kidney organ transplantation has been the most effective treatment fo…
Transitions in European land-management regimes between 1800 and 2010
2015
Land use is a cornerstone of human civilization, but also intrinsically linked to many global sustainability challenges—from climate change to food security to the ongoing biodiversity crisis. Understanding the underlying technological, institutional and economic drivers of land-use change, and how they play out in different environmental, socio-economic and cultural contexts, is therefore important for identifying effective policies to successfully address these challenges. In this regard, much can be learned from studying long-term land-use change. We examined the evolution of European land management over the past 200 years with the aim of identifying (1) key episodes of changes in land …
Blended transdiagnostic group CBT for emotional disorders: A feasibility trial protocol
2021
Introduction Emotional disorders (anxiety and depressive disorders) are a relevant public health concern associated with high prevalence, high costs, and important disability. Therefore, research priorities include designing and testing cost-effective interventions to reach everyone in need. Internet-delivered interventions for emotional disorders are effective and can help to disseminate and implement evidence-based treatments. However, although these treatments are generally effective, not all patients benefit from this treatment format equally. Blended treatments are a new form of intervention that combines the strengths of face-to-face and Internet approaches. Nevertheless, research on …
Description of movement sensor dataset for dog behavior classification
2022
The description and results of the original investigation are found in: Dog behaviour classification with movement sensors placed on the harness and the collar, Kumpulainen, P., Valldeoriola Cardó, A., Somppi, S., Törnqvist, H., Väätäjä, H., Majaranta, P., Gizatdinova, Y., Antink, C. H., Surakka, V., V. Kujala, M., Vainio, O. & Vehkaoja, A., Aug 2021, In: Applied Animal Behaviour Science. 241, 7 p., 105393. Movement sensor data from seven static and dynamic dog behaviors (sitting, standing, lying down, trotting, walking, playing, and (treat) searching i.e. sniffing) was collected from 45 middle to large sized dogs with six degree-of-freedom movement sensors attached to the collar and the ha…
A Novel Approach to Identify Candidate Prognostic Factors for Hepatitis C Treatment Response Integrating Clinical and Viral Genetic Data
2015
The combined therapy of pegylated interferon (IFN) plus ribavirin (RBV) has been for a long time the standard treatment for patients infected with hepatitis C virus (HCV). In the case of genotype 1, only 38%–48% of patients have a positive response to the combined treatment. In previous studies, viral genetic information has been occasionally included as a predictor. Here, we consider viral genetic variation in addition to 11 clinical and 19 viral populations and evolutionary parameters to identify candidate baseline prognostic factors that could be involved in the treatment outcome. We obtained potential prognostic models for HCV subtypes la and lb in combination as well as separately. We …