Search results for "informatics"
showing 10 items of 2542 documents
An Internet-delivered Cognitive-Behavioral Therapy (iCBT) for Prolonged Grief Disorder (PGD) in adults: A multiple-baseline single-case experimental …
2022
The death of a loved one has physical, psychological, and social consequences. Between 9.8 and 21.5 % of people who lose a loved one develop Prolonged Grief Disorder (PGD). Internet- and computer-based interventions (i.e., Internet-delivered Cognitive-Behavioral Therapy, iCBT) are cost-effective and scalable alternatives that make it possible to reach more people with PGD. The main goal of the present investigation was to examine the effect and feasibility (usability and satisfaction) of an iCBT (GROw program) for adults with PGD. A secondary objective was to detect adherence to the app (Emotional Monitor) used to measure daily grief symptoms. The study had a singlecase multiple-baseline AB…
Effects of a computerized decision support system on care planning for pressure ulcers and malnutrition in nursing homes: an intervention study.
2013
Author's accepted version (post-print). Background: Nursing documentation is essential for facilitating the flow of information to guarantee continuity, quality and safety in care. High-quality nursing documentation is frequently lacking; the implementation of computerized decision support systems is expected to improve clinical practice and nursing documentation. Aim: The present study aimed at investigate the effects of a computerized decision support system and an educational program as intervention strategies for improved nursing documentation practice on pressure ulcers and malnutrition in nursing homes. Design, setting and participants: An intervention study with two intervention grou…
Intranasal Insulin Administration to Prevent Delayed Neurocognitive Recovery and Postoperative Neurocognitive Disorder: A Narrative Review
2021
Delayed neurocognitive recovery and postoperative neurocognitive disorders are major complications of surgery, hospitalization, and anesthesia that are receiving increasing attention. Their incidence is reported to be 10–80% after cardiac surgery and 10–26% after non-cardiac surgery. Some of the risk factors include advanced age, level of education, history of diabetes mellitus, malnutrition, perioperative hyperglycemia, depth of anesthesia, blood pressure fluctuation during surgery, chronic respiratory diseases, etc. Scientific evidence suggests a causal association between anesthesia and delayed neurocognitive recovery or postoperative neurocognitive disorders, and various pathophysiologi…
Social welfare professionals willing to participate in client information system development - Results from a large cross-sectional survey.
2021
Human-centered design methods should be implemented throughout the client information system (CIS) development process to understand social welfare professionals’ needs, tasks, and contexts of use. The aim of this study was to examine Finnish social welfare professionals’ experiences of participating in CIS development. A national cross-sectional web-based survey on the CIS experiences of social welfare professionals (1145 respondents) was conducted in Finland in spring 2019. This study focused on statements concerning the experiences of end users with CIS development and participation. The results are reported by professional and age groups. Half (50%) of the 1145 respondents had participa…
Cardiorenal Syndrome: New Pathways and Novel Biomarkers
2021
Cardiorenal syndrome (CRS) is a multi-organ disease characterized by the complex interaction between heart and kidney during acute or chronic injury. The pathogenesis of CRS involves metabolic, hemodynamic, neurohormonal, and inflammatory mechanisms, and atherosclerotic degeneration. In the process of better understanding the bi-directional pathophysiological aspects of CRS, the need to find precise and easy-to-use markers has also evolved. Based on the new pathophysiological standpoints and an overall vision of the CRS, the literature on renal, cardiac, metabolic, oxidative, and vascular circulating biomarkers was evaluated. Though the effectiveness of different extensively applied biomark…
5-Imino-3,4-diphenyl-1H-pyrrol-2-one
2014
The title compound, C16H12N2O, exists in the crystalline state as the 5-imino-3,4-diphenyl-1H-pyrrol-2-one tautomer. The dihedral angles between the pyrrole and phenyl rings are 35.3 (2) and 55.3 (2)°. In the crystal, inversion dimers linked by pairs of N—H...N hydrogen bonds generate a graph-set motif ofR22(8)viaN—H...N hydrogen bonds.
2,3-Diphenylmaleimide 1-methylpyrrolidin-2-one monosolvate
2014
In the title compound, C16H11NO2·C5H9NO, the dihedral angles between the maleimide and phenyl rings are 34.7 (2) and 64.8 (2)°. In the crystal, the 2,3-diphenylmaleimide and 1-methylpyrrolidin-2-one molecules form centrosymmetrical dimersviapairs of strong N—H...O hydrogen bonds and π–π stacking interactions between the two neighboring maleimide rings [centroid–centroid distance = 3.495 (2) Å]. The dimers are further linked by weak C—H...O and C—H...π hydrogen bonds into a three-dimensional framework.
Sosiaalialan ammattilaiset halukkaita osallistumaan asiakastietojärjestelmien kehittämiseen – osallistumistavoissa kehitettävää
2020
Tietojärjestelmien kehittämistyön lähtökohtana tulee olla vahva ymmärrys käyttäjien tarpeista, tehtävistä sekä toimintaympäristöstä. Lisäksi suunnitteluratkaisuja tulee arvioida käyttäjien kanssa kehittämisprosessin aikana ja käyttöönoton jälkeen. Vaikka kansallisesti kohdennetaan runsaasti resursseja tietojärjestelmäpalveluiden kehittämiseen, sosiaalialalta tutkimusta aiheesta löytyy niukasti. Sosiaalialan ammattilaisten kokemuksia asiakastietojärjestelmien kehittämistyöstä kartoitettiin osana keväällä 2019 toteutettua valtakunnallisesta käyttäjäkokemuskyselyä. Kysymyksissä käsiteltiin kokemuksia yhteistyöstä tietojärjestelmätoimittajan kanssa, osallistumisesta kehittämistyöhön ja osallist…
The transcriptome analysis of Strongyloides stercoralis L3i larvae reveals targets for intervention in a neglected disease.
2012
Background: Strongyloidiasis is one of the most neglected diseases distributed worldwide with endemic areas in developed countries, where chronic infections are life threatening. Despite its impact, very little is known about the molecular biology of the parasite involved and its interplay with its hosts. Next generation sequencing technologies now provide unique opportunities to rapidly address these questions. Principal Findings: Here we present the first transcriptome of the third larval stage of S. stercoralis using 454 sequencing coupled with semi-automated bioinformatic analyses. 253,266 raw sequence reads were assembled into 11,250 contiguous sequences, most of which were novel. 8037…
Healthy mitochondria for stroke cells.
2018
Stroke is a debilitating disease that remains as a significant unmet need. Although our understanding of the disease pathology has advanced over the years, treatment options for stroke are limited. Recent studies have implicated the important role of healthy mitochondria in neuroprotection against stroke. Under the stroke pathological condition, transfer of healthy mitochondria is observed from astrocytes to ischemic neurons. However, without additional therapeutic intervention, such astrocyte-to-neuron transfer of mitochondria may not sufficiently afford a robust and stable therapeutic effect against the devastating primary insult and progressive neurodegeneration associated with stroke. W…