Search results for "infusion"
showing 10 items of 233 documents
Vitamin A in parenteral nutrition: uptake and distribution of retinyl esters after intravenous application.
1989
Short-term parenteral application of vitamin A was examined in rats. Retinyl margarinate, which is chemically similar to physiological retinyl esters, was used in vitamin A-depleted rats to study uptake, distribution, and storage of retinyl esters in tissues. Vitamin A-depleted and Vitamin A-sufficient rats were infused with a micellar suspension of retinyl margarinate for 7 h and then killed at different times. Retinyl margarinate was directly taken up by all tissues examined. It appears that infusion of retinyl esters in micellar form provides a direct way to supply vitamin A to peripheral, vitamin A-dependent tissues. Therefore, a short-term infusion of retinyl esters with an emulsifier …
Pharmacokinetics and pharmacodynamics of hydroxyethyl starch in hypovolemic pigs; a comparison of peripheral and intraosseous infusion.
1999
Intraosseous (i.o.) infusion is considered a useful technique for the administration of medications and fluids in emergency situations when peripheral intravascular access is not possible. This study investigated the effectiveness of i.o. versus intravenous (i.v.) infusion of hydroxyethyl starch (HES 200/0.5) in hypovolemic pigs. Twenty-three pigs (8- to 9-week-old) were anaesthesized, instrumented and blood was withdrawn (25-30 ml/kg) to50 mmHg mean arterial pressure (MAP). The animals were left untreated in haemorrhage for 30 min. Relevant haemodynamic parameters were monitored and blood samples were collected for blood gas and HES concentration analysis. Infusion of HES via i.v. or i.o. …
Graft-Versus-Host Disease or Infection: Rapid Detection of HLA Mismatch-Reactive T Cells Ex Vivo Can Facilitate Diagnosis and Guide Therapy after All…
2007
Abstract Diagnosis of graft-versus-host disease (GVHD) is mainly based on clinical features and on tissue biopsies. However, clinicians and pathologists are well aware of cases, in which GVHD cannot be distinguished from infections arising from severe immunodeficiency after allogeneic stem-cell transplantation (SCT). This may pose a deep therapeutic dilemma of whether to modify immunosuppressive treatment or to use donor lymphocyte infusion (DLI) for promoting anti-microbial immunity. We observed a 68-year-old patient with myelodysplastic syndrome who developed acute GVHD grade II of skin and gut at d+16 after T-cell depleted reduced-intensity SCT (Fig. 1). GVHD was confirmed by histology a…
Auswirkungen parenteraler Glycerinzufuhr auf die Glycerokinase-Aktivität und den Adenosintriphosphatspiegel in der Niere von Ratten
1975
Dauerinfusionen mit Glycerin an Ratten fuhren bei Dosierungen oberhalb der durchschnittlichen maximalen Umsatzkapazitat (0,74 g.kg−1.h−1) zu Veranderungen an den Nieren in Form einer Gewichtszunahme bei gleichzeitiger Proteinverarmung und eines Aktivitatsverlustes an Glycerokinase bei deren gleichzeitigem Auftreten im Harn. Bei Dosierungen von 0,6 g.kg−1.h−1 und mehr kommt es zu einem ATP-Abfall in den Nieren. Im Gegensatz dazu sind Veranderungen in der Leber uneinheitlicb und in ahnlicher Form nur bei Dosierungsraten oberhalb der maximalen Umsatzkapazitat zu finden. Die auftretenden Veranderungen werden im Zusammenhang biokinetischer Daten und des Begriffs der osmotischen Nephrose diskutie…
The bactericidal effect of extracts from Humulus lupulus L Marynka variety on selected bacteria
2020
The aim of the research was to obtain extracts of Humulus lupulus L hop cones of the Marynka variety and to evaluate their antibacterial properties against three strains of gram-negative bacteria (Escherichia coli ATCC 10536, E. coli IPS and Pseudomonas aeruginosa ATCC 27853) and against two strains of gram-positive bacteria (Enterococcus hirae ATCC 10541 and Bacillus cereus ATCC 12826). The research material consisted of dried Marynka variety hop cones, from which extracts in the form essential oil (EO), infusion and decoction were obtained. EO was obtained in the process of hydrodistillation. The antibacterial activity of the extracts was evaluated by the plate-cylinder diffusion method a…
PO-0994 Ltri In Paediatrics: Analysis Of An Annual Survey
2014
Background and aims Lower tract respiratory infections (LTRI) are very frequent in paediatric population. We collected epidemiological, etiological and clinical data and correlated them to some variables. Methods We performed an observational study of all children with a LTRI, admitted to our Paediatric Unit from February 2013 to January 2014. The population was grouped in three classes of ages (0–2yr, 3–6yr, >6yr). All patients underwent to a questionnaire focused on exposition to protective and risk factors for respiratory diseases. Results 83 children were included. We grouped them according to discharge diagnosis and analysed the distribution for ages, sex and season of onset. At the ad…
Stability of topotecan infusion solutions in polyvinylchloride bags and elastomeric portable infusion devices
1999
Purpose. The purpose of this study was to determine the physicochemical stability of topotecan after reconstitution and after further dilution in two commonly used infusion fluids (0.9% sodium chloride, 5% dextrose) in both polyvinylchloride (PVC) bags and elastomeric portable infusion devices. Methods. Each vial of topotecan (Hycamtin®) was reconstituted with sterile water for injection, yielding a nominal concentration of 1 mg/mL. Topotecan infusion solutions were aseptically prepared by further dilution of reconstituted topotecan solutions with either 0.9% sodium chloride or 5% dextrose in both PVC bags and portable elastomeric infusion devices, in amounts yielding topotecan concentrati…
Plasticizer extraction of Taxol infusion solution from various infusion devices.
1996
Taxol solution extracts the plasticizer DEHP (di(2-ethylhexyl)phthalate) from polyvinyl chloride (PVC) materials. In order to minimize patient exposure to DEHP, Taxol solutions should be prepared and administered in PVC-free materials. Particulate matter may form in Taxol infusion solution over time, so that in-line filtration with microporous membranes not greater than 0.22 microns is advisable. The purpose of this study was to evaluate the suitability of various administration- and in-line filter-sets for Taxol application. The extent of leached DEHP was determined using a Reversed Phase HPLC assay specific for DEHP. The four tested administration-sets, labeled as PVC-free, were all found…
Root damage induced by intraosseous anesthesia'An in vitro investigation
2012
Objectives: The principle of the intraosseous anesthesia (IOA) relies on the perforation of the cortical plate of the bone for direct application of the local anesthetic solution into the underlying cancellous structures. During this procedure, IOA needles might accidentally come in contact with the tooth roots. The aim of the current in vitro study was to examine the consequences of this ‘worst case scenario’ comparing five commercially available IOA systems. Material and Methods: Extracted human roots were randomly perforated using five different IOA systems with a drilling time ≤5s. To simulate normal in vivo conditions, the roots were kept humid during the drilling procedure. Data was s…
On the anti-inflammatory and anti-phospholipase A2 activity of extracts from lanostane-rich species
2000
Abstract We have studied extracts from three species rich in lanostane triterpenes for their activity against different in vivo models of inflammation induced by TPA, EPP and PLA2. The inhibitory effect against PLA2 in vitro was also studied. When the Poria cocos extract was tested against PLA2-induced mouse paw edema, it was active by the oral and parenteral routes. Its effect was greater in both magnitude and duration than that of Pistacia terebinthus and Ganoderma lucidum extracts. P. terebinthus was effective against chronic and acute inflammation, and according to a preliminary chromatographic analysis, its seems to be a good source of lanostane anti-inflammatory agents. G. lucidum was…