6533b7d3fe1ef96bd1260259
RESEARCH PRODUCT
On the anti-inflammatory and anti-phospholipase A2 activity of extracts from lanostane-rich species
José-luis RíosEva M Giner-larzaM. Carmen RecioSalvador MáñezRosa M. Giner-ponssubject
medicine.drug_classGanodermaAnti-Inflammatory AgentsAdministration OralPharmacognosyPharmacologyPistacia terebinthusLanostanePhospholipases AAnti-inflammatoryMicechemistry.chemical_compoundDrug DiscoverymedicineAnimalsEdemaMedicinal fungiInfusions ParenteralInflammationPharmacologyAnalysis of VariancebiologyPistaciaPlant ExtractsBiological activitybiology.organism_classificationTriterpenesBiochemistrychemistryFemalelipids (amino acids peptides and proteins)description
Abstract We have studied extracts from three species rich in lanostane triterpenes for their activity against different in vivo models of inflammation induced by TPA, EPP and PLA2. The inhibitory effect against PLA2 in vitro was also studied. When the Poria cocos extract was tested against PLA2-induced mouse paw edema, it was active by the oral and parenteral routes. Its effect was greater in both magnitude and duration than that of Pistacia terebinthus and Ganoderma lucidum extracts. P. terebinthus was effective against chronic and acute inflammation, and according to a preliminary chromatographic analysis, its seems to be a good source of lanostane anti-inflammatory agents. G. lucidum was the least effective of the three species studied and, unlike the other two, failed to inhibit the activity of PLA2 in vitro.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-10-12 | Journal of Ethnopharmacology |