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showing 10 items of 384 documents
Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.
2005
Contains fulltext : 48386.pdf (Publisher’s version ) (Closed access) Usher syndrome (USH) is the most frequent cause of combined deaf-blindness in man. USH is clinically and genetically heterogeneous with at least 11 chromosomal loci assigned to the three USH types (USH1A-G, USH2A-C, USH3A). Although the different USH types exhibit almost the same phenotype in human, the identified USH genes encode for proteins which belong to very different protein classes and families. We and others recently reported that the scaffold protein harmonin (USH1C-gene product) integrates all identified USH1 molecules in a USH1-protein network. Here, we investigated the relationship between the USH2 molecules a…
Using Polymeric Scaffolds for Vascular Tissue Engineering
2014
With the high occurrence of cardiovascular disease and increasing numbers of patients requiring vascular access, there is a significant need for small-diameter (<6 mm inner diameter) vascular graft that can provide long-term patency. Despite the technological improvements, restenosis and graft thrombosis continue to hamper the success of the implants. Vascular tissue engineering is a new field that has undergone enormous growth over the last decade and has proposed valid solutions for blood vessels repair. The goal of vascular tissue engineering is to produce neovessels and neoorgan tissue from autologous cells using a biodegradable polymer as a scaffold. The most important advantage of …
Unprecedented reactivity of a Schiff base ligand in the co-ordination sphere of copper(I) complex towards β-diketones. Synthesis and X-ray characteri…
2002
International audience; The reactions of the copper(I) derivative [CuL(THF)(CH3CN)]PF6 (1), in which L is the di-imine/pyridine ligand 2,6-bis[1-(2,6-diisopropylphenylimino)ethyl]pyridine, with different β-diketones (2,4-pentanedione (acacH), 1,3-diphenyl-1,3-propanedione (dbm)) yielded the new Cu(I) salt [CuL′2]PF6 (2) (L′: 2-[acetyl]-6-[1-(2,6-diisopropylphenylimino)ethyl]pyridine). These reactions of β-diketones with a di-imine/pyridine ligand co-ordinated to a Cu(I) centre constitute the first example of a partial hydrolysis of such a Schiff base within the inner sphere of a Cu centre. Compound 2·acaH has been characterised by X-ray crystallography. © 2002 Elsevier Science B.V. All righ…
Imbalance between sympathetic and sensory innervation in peritoneal endometriosis
2011
To investigate possible mechanisms of pain pathophysiology in patients with peritoneal endometriosis, a clinical study on sensory and sympathetic nerve fibre sprouting in endometriosis was performed. Peritoneal lesions (n= 40) and healthy peritoneum (n= 12) were immunostained and analysed with anti-protein gene product 9.5 (PGP 9.5), anti-substance P (SP) and anti-tyrosine hydroxylase (TH), specific markers for intact nerve fibres, sensory nerve fibres and sympathetic nerve fibres, respectively, to identify the ratio of sympathetic and sensory nerve fibres. In addition, immune cell infiltrates in peritoneal endometriotic lesions were analysed and the nerve growth factor (NGF) and interleuki…
The Embioptera from the Strait of Sicily Islands: first records from Pantelleria and Lampedusa and new data from Lampione (Sicily, Italy)
2021
The occurrence of Embioptera in the Strait of Sicily islands was up to date known only from Lam pione (the smallest of the Pelagie islands), where the only species reported was provisionally assigned to Embia ramburi Rimski-Korsakow, 1905. Based on material recently collected by the authors, the presence of Embioptera is here reported for the first time in the Islands of Pantelleria (Sicily, Trapani) and Lampedusa (Sicily, Agrigento). In the Island of Pantelleria the occurrence of the typical small silky tunnels produced by Embioptera has been verified in many sites, from sea level to Montagna Grande (836 m). In many of these sites, several juveniles and some adult or subadult specimens wer…
Functional Aspects of Adrenocholinergic and Peptidergic Innervation about Prostate and Seminal Vesicles in Mammals: A Review
2009
This study was aimed to explain the functional role of mediation in the organs of the male reproductive system (prostate and seminal vesicles of rat and hamster), representing throught the visualization of adrenergic fibres (Falck Method), cholinergic fobres (Martinez-Rodriguez method) and by immunohistochemical methods to detect the P substance and the CGRP (PAP) in glandular structures. The adrenocholinergic and peptidergic mediators have a growing interest for their synergic action in the control of contractility, vasodilatation and most likely, of the secretory activity of the epithelium, probably expressed by andocrine-paracrine mechanisms.
Architecture of the NYT caldera and inner resurgent dome (Pozzuoli Bay, Campi Flegrei): new insights from seismic reflection and DInSAR data
2016
The Campi Flegrei and its offshore prolongation (Pozzuoli Bay) are a volcanic area dominated by a collapse caldera associated with the Neapolitan Yellow Tuff (NYT) eruption, occurred at ~15 ka BP, and by an intra-caldera resurgent dome. We present new insights into: a) the geometry and kinematics of faults formed inside and at the edge of the caldera, b) the architecture of the caldera and the resurgent dome, and c) the relationship between the structural elements of the caldera and ground deformation. This work is based on the integration of single- and multi- channel seismic, swath bathymetry data and ground deformation maps. The main results highlight that the NYT caldera, offshore, is c…
Architecture of the NYT caldera and inner resurgent dome (Pozzuoli Bay, Campi Flegrei): new insights from seismic reflection and DInSAR data
2016
The Campi Flegrei and its offshore prolongation (Pozzuoli Bay) are a volcanic area dominated by a collapse caldera associated with the Neapolitan Yellow Tuff (NYT) eruption, occurred at ~15 ka BP, and by an intra-caldera resurgent dome. We present new insights into: a) the geometry and kinematics of faults formed inside the caldera, b) the architecture of the resurgent dome, and c) the relationship between the structural elements of the resurgent dome and ground deformations. This work is based on the integration of high- and ultra-high resolution seismic data, swath bathymetry data and ground deformation maps. The main results highlight that the NYT caldera, offshore, is characterized by a…
Habitat mapping of VMEs along the inner shelf regions of the south-western Tyrrhenian margin (southern Mediterranean): a geo-statistical predictive a…
2016
The main aim of this work is to statistically predict the distribution of Vulnerable Marine Ecosystems (VMEs) along the continental shelf regions of the northern Sicilian margin (southern Mediterranean). The considered habitats, already mapped in the area on a qualitative base, are the Posidonia oceanica and Cymodocea nodosa seagrasses and the Coralligenous biocenosis. Posidonia oceanica and Coralligenous are considered as VMEs owing to their value as environmental indicators and biodiversity hotspots in coastal marine areas. For this reason, several actions were aimed in recent years to their complete characterization and mapping. The study area is located in the continental shelf of the n…
Indagine sperimentale sui segnali sonori all’interno dei rotabili per la diagnosi dello stato dell’armamento ferroviario
2003
The maintenance of track provides an relatively frequent operations. A good maintenance-planning allows to reduce the interference between rail traffic and maintenance operations. It is necessary so to use a monitoring system of track conditions. In this paper is showed an indirect monitoring system that correlates track conditions and typical spectrum of in-cab noise. The first results of experimental survey are reported.