Search results for "insert"
showing 10 items of 440 documents
An Open-Label Phase II Study Evaluating the Safety and Efficacy of Ramucirumab Combined With mFOLFOX-6 as First-Line Therapy for Metastatic Colorecta…
2014
Abstract Author Summary Background. Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR-2) are believed to mediate angiogenesis in colorectal cancer (CRC). Ramucirumab (RAM; IMC-1121B) is a human IgG1 monoclonal antibody that inhibits VEGF ligand binding to VEGFR-2, inhibiting VEGFR-2 activation and signaling. Methods. Patients with metastatic CRC, Eastern Cooperative Oncology Group performance status 0–1, and adequate organ function who had not received chemotherapy for metastatic disease received RAM and the modified FOLFOX-6 regimen every 2 weeks. Endpoints included progression-free survival (PFS), objective response rate, overall survival, and safety. The sample size wa…
VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.
2010
Inflammation drives expression of VEGFR2, which is expressed on and drives growth of tumor cells in colitis-associated cancer.
Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis
2011
Fibronectin (FN) is a major component of the extracellular matrix and functions in cell adhesion, cell spreading and cell migration. In the retina, FN is transiently expressed and assembled on astrocytes (ACs), which guide sprouting tip cells and deposit a provisional matrix for sprouting angiogenesis. The precise function of FN in retinal angiogenesis is largely unknown. Using genetic tools, we show that astrocytes are the major source of cellular FN during angiogenesis in the mouse retina. Deletion of astrocytic FN reduces radial endothelial migration during vascular plexus formation in a gene dose-dependent manner. This effect correlates with reduced VEGF receptor 2 and PI3K/AKT signalli…
Dopamine agonist administration causes a reduction in endometrial implants through modulation of angiogenesis in experimentally induced endometriosis
2009
Survival of newly implanted retrograde-shed endometrial tissue during menstruation in an ectopic location requires an adequate blood supply. This suggests that angiogenesis is a prerequisite for the development of endometriosis and that its inhibition may be a target for preventing development. Previous studies have shown that vascular endothelial growth factor (VEGF), a heparin-binding glycoprotein, has an essential role in angiogenesis. The main regulatory factor for angiogenesis appears to be binding of VEGF to its type-2 receptor (VEGFR-2). Cabergoline (Cb2) and other dopamine agonists promote endocytosis of the VEGF receptor-2 (VEGFR-2) in endothelial cells, thereby preventing VEGF-VEG…
Performance analysis and comparison of symmetrical and asymmetrical configurations of evanescent mode ridge waveguide filters
2009
[1] In this paper, the trade-offs between out-of-band performance, filter length, power-handling capability, and insertion loss of both symmetrical and asymmetrical evanescent mode ridge rectangular waveguide filters are investigated. As a result, clear design methodologies for optimizing such performances are proposed. The developed methodologies are then applied to design several evanescent mode filters, and a complete performance analysis of the symmetrical and asymmetrical structures is performed. From the performance analysis results, the designer can choose the more appropriate filter topology and design strategy to satisfy the prescribed specifications.
Deciphering the role of insertion sequences in the evolution of bacterial epidemic pathogens with panISa software
2020
Next-generation sequencing (NGS) is now widely used in microbiology to explore genome evolution and the structure of pathogen outbreaks. Bioinformatics pipelines readily detect single-nucleotide polymorphisms or short indels. However, bacterial genomes also evolve through the action of small transposable elements called insertion sequences (ISs), which are difficult to detect due to their short length and multiple repetitions throughout the genome. We designed panISa software for the ab initio detection of IS insertions in the genomes of prokaryotes. PanISa has been released as open source software (GPL3) available from https://github.com/bvalot/panISa. In this study, we assessed the utilit…
On the mechanisms involved in the tensile strength of a dissimilar Ti6Al4V/316L laser welded assembly
2021
International audience; The aim of the present work is to analyze the thermomechanical behavior of dissimilar laser seams by means of FE modeling. The case of a Ti6Al4V/316L assembly with vanadium insert was considered. Effective mechanical properties of the main materials and cords were first estimated from NHT measurements. Modeling of the double pass laser welding process was performed first by considering shrinking of the two weld seams during manufacturing, to get the residual stress state in the welded assembly. Modeling of the tensile test was performed in a second step to study the assembly behavior during loading. In these modeling results, the mesh was the cross-section of the mic…
Forte baisse de l'embauche des jeunes en Bourgogne
2010
Réalisée en Bourgogne depuis vingt-cinq ans, l'enquête Insertion dans la vie active constitue un outil particulier et unique qui donne la possibilité de suivre l'évolution des conditions d'entrée des jeunes sur le marché du travail. Cette note présente les résultats de la dernière interrogation menée en février 2009, et donne un aperçu de la transition de l'école à l'emploi. En Bourgogne, 7 400 élèves et 4 800 apprentis âgés de 20 ans en moyenne, ont été interrogés sur leur situation professionnelle. Sept mois après la fin des études, 47 % des filles et 55 % des garçons sont salarié-e-s en février 2009. Les jeunes de la région n'échappent pas à la crise économique internationale illustrée p…
De la formation à l'emploi : une transition difficile
2006
Pour connaître le devenir des anciens élèves et apprentis, le ministère de l'Éducation nationale réalise des enquêtes depuis de nombreuses années, avec l'appui des établissements scolaires et des centres de formation d'apprentis. Cette note présente les résultats des dernières enquêtes effectuées en 2005, qui appréhendent les situations des jeunes sept mois après la fin de leurs études en Bourgogne.
L'entrée dans la vie active des jeunes de Bourgogne
2007
Pour connaître le devenir des anciens élèves et apprentis, le ministère de l'Éducation nationale réalise des enquêtes depuis de nombreuses années, avec l'appui des établissements scolaires et des centres de formation. Cette note présente les résultats de la dernière enquête effectuée en 2006, qui appréhende les situations des jeunes sept mois après la fin de leur scolarité en Bourgogne.