Search results for "instability"

Erratum: The runaway instability of thick discs around black holes - II. Non-constant angular momentum discs

2004

Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts.

2006

Alterations in the number and/or morphology of centrosomes are frequently observed in human tumours. However, it is still debated if a direct link between supernumerary centrosomes and tumorigenesis exists and if centrosome amplification could directly cause aneuploidy. Here, we report that hydroxyurea treatment induced centrosome amplification in both human fibroblasts expressing the HPV16 -E6-E7 oncoproteins, which act principally by targeting p53 and pRB, respectively, and in conditional pRB deficient mouse fibroblasts. Following hydroxyurea removal both normal and p53 deficient human fibroblasts arrested. On the contrary pRB deficient fibroblasts entered the cell cycle generating aneupl…

Emergence of extreme events in fiber-based parametric processes driven by a partially incoherent pump wave

2009

Modulation instability (MI) generated by a picosecond coherent pulse has been recently identified as the key element of the generation of optical rogue-waves in supercontinuum-based systems [1]. Similar rare but highly energetic pulse structures can also appear in non-solitonic configurations such as Raman amplifiers driven by a partially incoherent pump wave propagating in fibres with low group velocity dispersion [2]. Therefore, one may wonder whether optical rogue-like event can also occur in MI-based amplifier because both Raman and parametric amplifiers benefit from a quasi-instantaneous gain. We provide here experimental evidence of rare optical events in a parametric amplifier in pre…

Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair

2015

Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by translation to the protein level, by transcription factors (e.g. NF-κB, HIF-1α) and mRNA binding proteins (e.g. GAPDH, HuR) is subject to redox regulation. This review will give an update of recent discoveries in this field, and specifically highlight the impact of reactive oxygen and nitrogen species on DNA repair systems that contribute to genomic stability. Emphasis will be placed …

The B0.5IVe CoRoT target HD 49330. I. Photometric analysis from CoRoT data

2009

International audience; Context: Be stars undergo outbursts producing a circumstellar disk from the ejected material. The beating of non-radial pulsations has been put forward as a possible mechanism of ejection. Aims: We analyze the pulsational behavior of the early B0.5IVe star HD 49330 observed during the first CoRoT long run towards the Galactical anticenter (LRA1). This Be star is located close to the lower edge of the beta Cephei instability strip in the HR diagram and showed a 0.03 mag outburst during the CoRoT observations. It is thus an ideal case for testing the aforementioned hypothesis. Methods: We analyze the CoRoT light curve of HD 49330 using Fourier methods and non-linear le…

Preventing the oil film instability in rotor-dynamics

2016

Horizontal rotor systems on lubricated journal bearings may incur instability risks depending on the load and the angular speed. The instability is associated with the asymmetry of the stiffness matrix of the bearings around the equilibrium position, in like manner as the internal hysteretic instability somehow, where some beneficial effect is indeed obtainable by an anisotropic configuration of the support stiffness. Hence, the idea of the present analysis is to check if similar advantages are also obtainable towards the oil film instability. The instability thresholds are calculated by usual methods, such as the Routh criterion or the direct search for the system eigenvalues. The results …

Viscous dissipation and thermoconvective instabilities in a horizontal porous channel heated from below

2010

Accepted version of av article from the journal: International Journal of Thermal Sciences. Published version available on Science Direct: http://dx.doi.org/10.1016/j.ijthermalsci.2009.10.010 A linear stability analysis of the basic uniform flow in a horizontal porous channel with a rectangular cross section is carried out. The thermal boundary conditions at the impermeable channel walls are: uniform incoming heat flux at the bottom wall, uniform temperature at the top wall, adiabatic lateral walls. Thermoconvective instabilities are caused by the incoming heat flux at the bottom wall and by the internal viscous heating. Linear stability against transverse or longitudinal roll disturbances …

Polarization mode dispersion and vectorial modulational instability in air silica microstructure fiber

2002

The birefringence of an air-silica microstructure fiber has been studied by measurement of the fiber polarization mode dispersion (PMD) over the wavelength range 545-640 nm. The experimental results are shown to be in good agreement with vectorial numerical calculations, assuming an elliptical core with an eccentricity of 7%. We also report controlled experiments studying nonlinear vectorial modulation instability in the fiber, yielding 3.9-THz modulational instability sideband shifts that are in good agreement with theoretical predictions based on the calculated fiber dispersion and PMD characteristics.

Gravitational Waves from the Papaloizou-Pringle Instability in Black-Hole-Torus Systems

2011

Black hole (BH)--torus systems are promising candidates for the central engine of gamma-ray bursts (GRBs), and also possible outcomes of the collapse of supermassive stars to supermassive black holes (SMBHs). By three-dimensional general relativistic numerical simulations, we show that an $m=1$ nonaxisymmetric instability grows for a wide range of self-gravitating tori orbiting BHs. The resulting nonaxisymmetric structure persists for a timescale much longer than the dynamical one, becoming a strong emitter of large amplitude, quasiperiodic gravitational waves. Our results indicate that both, the central engine of GRBs and newly formed SMBHs, can be strong gravitational wave sources observa…

"Only Spinal Fixation" as Surgical Treatment of Cervical Myelopathy Related to Ossified Posterior Longitudinal Ligament: Review of 52 Cases.

2020

Background Ossification of the posterior longitudinal ligament (OPLL) is a hyperostotic condition resulting in a progressive narrowing of the spinal canal and subsequent neurologic deficits. Although systemic and local factors in combination with genetic abnormality have been considered in its etiopathogenesis, OPLL remains a poorly understood pathology. Surgical management of OPLL and the choice of the most appropriate treatment are still controversial issues. Here the authors report a series of OPLL-affected patients treated by “only-fixation” technique. Methods Between June 2012 and June 2019, 52 patients having OPLL were treated by a surgical strategy involving only spinal fixation with…