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Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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La dimensione tecnologica del museo: forme, tecniche, "identità mutanti" tra storia e contemporaneità

2005

Nella cultura contemporanea il tema della conservazione dell’eredità storica, della rappresentazione e della trasmissibilità dell’arte è argomento ampiamente dibattuto. La forza culturale del museo, detentore dell’eredità, può essere interpretata secondo diverse traiettorie di forme. La memoria intende esprimersi sulle origini e sul significato della "macchina museale" attraverso l’analisi critica dell’oggetto, sia esso contenitore, palco di rappresentazione o scena interattiva. Sonda i processi di comunicazione relativamente alla forma architettonica, alla funzione ed alla fruizione del prodotto espositivo. Tenendo conto delle diverse scuole di pensiero sulla spettacolarizzazione dell’arte…

In present days the storical heritage the transmission of art and its performance is very important argument of debate. Its representation is the building museum in many different forms. The building museum of art is the most important place for exsposition of masterpieces instead the museum of architecture exhibits the works through projects and patterns. Today museum reconstructs the human perception of space using new technologies. The same thing happens for the museum of science and technique where the visitor gets involved in scientific representation. Therefore museum can be a place of study and scientific research. It can be either memory of past times or place of contemporaneity. This study expresses origin and meaning of building museum through the critical analysis of architectonic forms technological aims and the proper use of the exspositive space.Settore ICAR/12 - Tecnologia Dell'Architettura
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Hacia la ley europea del clima: las evaluaciones científicas y el futuro papel de las respuestas jurídicas de los estados miembros

2021

Los problemas climáticos son temas persistentes y omnipresentes dentro de las políticas y legislaciones contemporáneas, que exigen un enfoque interdisciplinario para promover soluciones jurídicas adecuadas para la complejidad del tema. Paradójicamente, las propagandas negacionistas, lejos de bloquear las acciones climáticas, las han propiciado, lo que ha llevado al establecimiento de un organismo científico super partes que reconociese las cuestiones climáticas a través de informes científicos avanzados: el Grupo Intergubernamental de Expertos sobre el Cambio Climático de la ONU (IPCC). Desde entonces, muchos países han usado los hallazgos del IPCC como base científica para desarrollar polí…

:CIENCIAS JURÍDICAS [UNESCO]Cambio Climático; Ley Europea del Clima; Pacto Verde Europeo IPCC; Derecho Público Comparadoas well as on the role that EU Members States? legislations will play in facing climate issues. Cambio climáticoIPCC2070-8157 22082 Revista Boliviana de Derecho 584568 2021 32 8055237 Hacia la ley europea del clima las evaluaciones científicas y el futuro papel de las respuestas jurídicas de los estados miembros ViolaEuropean Climate Lawinstead of blocking climate actionsleading to the establishment of a super partes scientific body that has acknowledged climate issues through the most advanced scientific reports: the UN Intergovernmental Panel on Climate Change (IPCC). Since thenPublic Comparative Law. 758 773demanding an interdisciplinary approach to foster legal solutions suitable for the complexity of the subject. Paradoxicallyhave fostered themEU Green DealPasquale Climate issues are persistent and pervasive topics within contemporary policies and legislationsmany countries have adopted the findings of the IPCC as scientific basis for developing strategic policies and legislation with the aim of combining adaptation and mitigation efforts. To this extentmainly focusing on the IPCC scientific basis and the proposed EU regulation related to climate changePacto Verde Europeo IPCCUNESCO::CIENCIAS JURÍDICASPacto Verde EuropeoCambio ClimáticoDerecho Público Comparadothe EU Green Deal and the future European Climate Law exemplify such contemporary attitude. This essay analyses the aforementioned assumptionsClimate changeLey Europea del Climanegationist claimsthe UN Intergovernmental Panel on Climate Change (IPCC). Since then [leading to the establishment of a super partes scientific body that has acknowledged climate issues through the most advanced scientific reports]
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Post-fotografia etnografica

2021

È evidente come la nostra società tecnologica sia legata senza alcun dubbio alla diffusione delle immagini. Autori come Gottfried Boehm, John Mitchell, Hans Belting hanno indagato la natura dell'immagine ponendo le basi, negli anni Novanta, per l'idea di un pictorial turn, di una cultura totalmente dominata dalle immagini che è diventata adesso una possibilità tecnica reale su scala globale. Un nuovo statuto dell'immagine che si usa raccogliere sotto l'etichetta di iconic turner inserito nel più vasto campo visual culture studies. L'uso del termine cultura accanto a quello di visuale è indicativo dell'ampiezza del campo d'indagine che visual culture studies si prefiggono di ricercare: essi …

It is evident that our technological society is undoubtedly linked to the diffusion of images. Authors such as Gottfried Boehm John Mitchell Hans Belting investigated the nature of the image by laying the foundations in the 1990s for the idea of ​​a pictorial turn of a culture totally dominated by images that has now become a real technical possibility on global scale. A new statute of the image that is used to collect under the label of iconic turner inserted in the wider field of visual culture studies. The use of the term culture alongside that of visual is indicative of the breadth of the field of investigation that visual culture studies aim to seek: they do not want to limit themselves to ascertaining the predominance of the visual in contemporary society and an evaluation of its aesthetic component. but they want to proceed towards an anthropological research in which visual culture is analyzed as a particular lifestyle that expresses certain meanings and values ​​not only in art and high culture but also in institutions and daily behavior. We will try to apply this new paradigm to photographs: instead of asking ourselves what the images mean let's try to ask ourselves what they want.
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Ambiente e diritto penale: brevi riflessioni fra le modifiche agli artt.9 e 41 Cost. e le prospettive di riforma in ambito internazionale

2023

l contributo analizza l’impatto che il recente inserimento dell’ambiente in Costituzione può dispiegare in ambito penale, tanto rispetto all’ambiente quale oggetto della tutela penale, quanto sul versante della selezione dei modelli di illecito, soffermandosi in particolare sul problema delle possibili ricadute penalistiche del nuovo vincolo di solidarietà ecologica di tipo intergenerazionale. Seguendo il fil rouge del bene giuridico, la seconda parte del saggio ricostruisce invece i punti critici e le prospettive di sviluppo del diritto penale ambientale internazionale, alla luce della nozione di ambiente quale bene giuridico comune ed universale.

The paper analyses the impact that the recent inclusion of the environment in the Italian Constitution may have in the criminal law both with respect to the criminally relevant notion of the environment and with regard to the selection of the types of criminal offences. From this point of view the paper also takes into consideration the penal significance of the new bond of intergenerational ecological solidarity. Following the file rouge of the “bene giuridico” the second part of the essay is instead dedicated to the description of the critical points and the possible developments of international environmental criminal law in the light of a conception of the environment as a common and universal legal good.Settore IUS/17 - Diritto Penale
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