Search results for "integumentary system"
showing 10 items of 744 documents
Skin Erythema Assessment by an RGB Imaging Device: a Clinical Study
2015
In this study, skin erythema assessment of 90 rosacea patients was estimated by a simple, low-cost RGB imaging device. A new erythema index assessment algorithm is proposed and clinically validated. Comparison with dermatologist’s visual assessment shows high correlation.
SiRNA-mediated selective inhibition of mutant keratin mRNAs responsible for the skin disorder pachyonychia congenita.
2006
RNA interference offers a novel approach for treating genetic disorders including the rare monogenic skin disorder pachyonychia congenita (PC). PC is caused by mutations in keratin 6a (K6a), K6b, K16, and K17 genes, including small deletions and single nucleotide changes. Transfection experiments of a fusion gene consisting of K6a and a yellow fluorescent reporter (YFP) resulted in normal keratin filament formation in transfected cells as assayed by fluorescence microscopy. Similar constructs containing a single nucleotide change (N171K) or a three-nucleotide deletion (N171del) showed keratin aggregate formation. Mutant-specific small inhibitory RNAs (siRNAs) effectively targeted these site…
Tetraspanin CD151 Mediates Papillomavirus Type 16 Endocytosis
2013
ABSTRACT Human papillomavirus type 16 (HPV16) is the primary etiologic agent for cervical cancer. The infectious entry of HPV16 into cells occurs via a so-far poorly characterized clathrin- and caveolin-independent endocytic pathway, which involves tetraspanin proteins and actin. In this study, we investigated the specific role of the tetraspanin CD151 in the early steps of HPV16 infection. We show that surface-bound HPV16 moves together with CD151 within the plane of the membrane before they cointernalize into endosomes. Depletion of endogenous CD151 did not affect binding of viral particles to cells but resulted in reduction of HPV16 endocytosis. HPV16 uptake is dependent on the C-termina…
In vitro contamination of hair by marijuana smoke.
2004
Abstract Background: The deposition of cannabinoids on/into hair from environmental smoke can be considered as a potential source of drug findings in hair. We studied external uptake of cannabinoids from marijuana smoke, investigating possible influencing factors on drug uptake and the efficiency of decontamination procedures. Methods: Strands of a natural hair sample were moistened with water, greased with sebum or sebum/sweat, or bleached or permed. Treated and untreated samples were exposed to marijuana smoke for 60 min. Aliquots of each hair strand were either kept unwashed or were washed with methanol, dichloromethane, or 5 g/L dodecyl sulfate in water. Cannabinoid concentrations in un…
First report of Antigastra catalaunalis on sesame in Greece.
2017
Τον Αύγουστο του 2016, καταγράφηκαν σοβαρές προσβολές σε καλλιέργειες σουσαμιού από το έντομο Antigastra catalaunalis (Duponchel) (Lepidoptera: Crambidae) σε αγροτικές περιοχές της Περιφερειακής Ενότητας Δράμας. Το A. catalaunalis είναι ένας σημαντικός εχθρός της καλλιέργειας του σουσαμιού σε περιοχές όπου αυτό καλλιεργείται. Παρατηρήθηκαν συμπτώματα προσβολής από τις προνύμφες του εντόμου σε φύλλα, βλαστούς και κάψες. Οι προσβολές καταγράφηκαν σε όλους τους αγρούς με καλλιέργεια σουσαμιού που επιθεωρήθηκαν, με επίπεδα προσβολής υψηλά τα οποία προκάλεσαν οικονομική απώλεια. Στο βαθμό που γνωρίζουμε, αυτή είναι η πρώτη αναφορά σοβαρών προσβολών σουσαμιού από το Α. catalaunalis στην Ελλάδα.
Solar Surface Magnetism and Irradiance on Time Scales from Days to the 11-Year Cycle
2009
The uninterrupted measurement of the total solar irradiance during the last three solar cycles and an increasing amount of solar spectral irradiance measurements as well as solar imaging observations (magnetograms and photometric data) have stimulated the development of models attributing irradiance variations to solar surface magnetism. Here we review the current status of solar irradiance measurements and modelling efforts based on solar photospheric magnetic fields. Thereby we restrict ourselves to the study of solar variations from days to the solar cycle. Phenomenological models of the solar atmosphere in combination with imaging observations of solar electromagnetic radiation and meas…
The conversion from cellulose I to cellulose II in NaOH mercerization performed in alcohol–water systems: An X-ray powder diffraction study
2007
Abstract The slurry-mercerization (SM) processes in 2-propanol–water and 2-propanol–ethanol–water and wet-mass-mercerization (WMM) process in ethanol–water solvents are investigated. Based on X-ray diffraction measurements in the earlier reports, we have derived a mathematical method to evaluate more exactly the conversion of cellulose I (CI) to cellulose II (CII) and used it to survey the effects of different alkali treatments on cellulose crystals. This method is very useful when the crystal system changes in a certain set of experiments are compared with each other. The optimal alcohol concentration in SM processes was found to be 80–92 w/w-% in 2-propanol–water solution, 85–90 w/w-% in …
Genetic parameters for somatic cell score according to udder infection status in Valle del Belice dairy sheep and impact of imperfect diagnosis of in…
2010
Abstract Background Somatic cell score (SCS) has been promoted as a selection criterion to improve mastitis resistance. However, SCS from healthy and infected animals may be considered as separate traits. Moreover, imperfect sensitivity and specificity could influence animals' classification and impact on estimated variance components. This study was aimed at: (1) estimating the heritability of bacteria negative SCS, bacteria positive SCS, and infection status, (2) estimating phenotypic and genetic correlations between bacteria negative and bacteria positive SCS, and the genetic correlation between bacteria negative SCS and infection status, and (3) evaluating the impact of imperfect diagno…
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives
2012
Abstract A series of 3-hydroxybenzo[ b ]thiophene-2-carboxylic acid derivatives has been prepared and subsequently evaluated with regards to the inhibition of 5-LOX/COX. Structure optimization furnished derivatives with promising in vitro activity as dual 5-LOX/COX inhibitors with submicromolar IC 50 values for inhibition of 5-LOX and COX-1, respectively.
Spontaneous extrusion of male genital pearling
2021
Pearling is a practice of inserting small beads beneath the skin of the genitalia. Patients generally underwent this practice believing that this would have made their penis bigger and able to better satisfy their partners during intercourse. Pearling can cause complications. We report a case of spontaneous extrusion of genital pearling exiting in a granuloma of the inner face of the foreskin.