Search results for "interference"
showing 10 items of 573 documents
Similar Regulation of Human Inducible Nitric-oxide Synthase Expression by Different Isoforms of the RNA-binding Protein AUF1
2008
The ARE/poly-(U) binding factor 1 (AUF1), a protein family consisting of four isoforms, is believed to mediate mRNA degradation by binding to AU-rich elements (ARE). However, evidence exists that individual AUF1 isoforms may stabilize ARE-containing mRNAs. The 3'-untranslated region of the human inducible nitric-oxide synthase (iNOS) contains five AREs, which promote RNA degradation. We have recently shown that the RNA-binding protein KSRP is critically involved in the decay of the iNOS mRNA. In this study we examined the effects of the individual AUF1 isoforms on iNOS expression. Overexpression of each AUF1 isoform reduces iNOS expression on mRNA and protein levels to the same extent by mo…
Hsp70 is required for optimal cell proliferation in mouse A6 mesoangioblast stem cells.
2009
Mouse Hsp70 (70 kDa heat shock protein) is preferentially induced by heat or stress stimuli. We previously found that Hsp70 is constitutively expressed in A6 mouse mesoangioblast stem cells, but its possible role in these cells and the control of its basal transcription remained unexplored. Here we report that in the absence of stress, Ku factor is able to bind the HSE (heat shock element) consensus sequence in vitro, and in vivo it is bound to the proximal hsp70 promoter. In addition, we show that constitutive hsp70 transcription depends on the co-operative interaction of different factors such as Sp1 (specificity protein 1) and GAGA-binding protein with Ku factor, which binds the HSE cons…
The Evolutionary Conserved Transmembrane BAX Inhibitor Motif (TMBIM) Containing Protein Family Members 5 and 6 Are Essential for the Development and …
2021
Frontiers in cell and developmental biology 9, 666484 (2021). doi:10.3389/fcell.2021.666484 special issue: "Cell Death and Survival / You-Wen He, Speciality Chief Editor; Craig Michael Walsh, Speciality Chief Editor; Arm Ruhul Amin, Associate Editor; Gustavo P. Amarante-Mendes, Associate Editor"
Interference Cancellation for LoRa Gateways and Impact on Network Capacity
2021
In this paper we propose LoRaSyNc (LoRa receiver with SyNchronization and Cancellation), a second generation LoRa receiver that implements Successive Interference Cancellation (SIC) and time synchronization to improve the performance of LoRa gateways. Indeed, the chirp spread spectrum modulation employed in LoRa experiences very high capture probability, and cancelling the strongest signal in case of collisions can significantly improve the cell capacity. An important feature of LoRaSyNc is the ability to track the frequency and clock drifts between the transmitter and receiver, during the whole demodulation of the interfered frame. Due to the use of low-cost oscillators on end-devices, a s…
IEEE Access Special Section Editorial : Cloud and Big Data-Based Next-Generation Cognitive Radio Networks
2019
In cognitive radio networks (CRN), secondary users (SUs) are required to detect the presence of the licensed users, known as primary users (PUs), and to find spectrum holes for opportunistic spectrum access without causing harmful interference to PUs. However, due to complicated data processing, non-real-time information exchange and limited memory, SUs often suffer from imperfect sensing and unreliable spectrum access. Cloud computing can solve this problem by allowing the data to be stored and processed in a shared environment. Furthermore, the information from a massive number of SUs allows for more comprehensive information exchanges to assist the resource allocation and interference ma…
A glimpse of gluons through deeply virtual compton scattering on the proton
2017
The internal structure of nucleons (protons and neutrons) remains one of the greatest outstanding problems in modern nuclear physics. By scattering high-energy electrons off a proton we are able to resolve its fundamental constituents and probe their momenta and positions. Here we investigate the dynamics of quarks and gluons inside nucleons using deeply virtual Compton scattering (DVCS)—a highly virtual photon scatters off the proton, which subsequently radiates a photon. DVCS interferes with the Bethe-Heitler (BH) process, where the photon is emitted by the electron rather than the proton. We report herein the full determination of the BH-DVCS interference by exploiting the distinct energ…
Suppression law of quantum states in a 3D photonic fast Fourier transform chip
2015
The identification of phenomena able to pinpoint quantum interference is attracting large interest. Indeed, a generalization of the Hong–Ou–Mandel effect valid for any number of photons and optical modes would represent an important leap ahead both from a fundamental perspective and for practical applications, such as certification of photonic quantum devices, whose computational speedup is expected to depend critically on multi-particle interference. Quantum distinctive features have been predicted for many particles injected into multimode interferometers implementing the Fourier transform over the optical modes. Here we develop a scalable approach for the implementation of the fast Fouri…
Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila melanogaster
2021
AbstractHost-pathogen interactions impose recurrent selective pressures that lead to constant adaptation and counter-adaptation in both competing species. Here, we sought to study this evolutionary arms-race and assessed the impact of the innate immune system on viral population diversity and evolution, using D. melanogaster as model host and its natural pathogen Drosophila C virus (DCV). We first isogenized eight fly genotypes generating animals defective for RNAi, Imd and Toll innate immune pathways and also pathogen sensing and gut renewal pathways. Wild-type or mutant flies were then orally infected and DCV was serially passaged ten times. Viral population diversity was studied after ea…
Clonal Interference and the Evolution of RNA Viruses
1999
In asexual populations, beneficial mutations that occur in different lineages compete with one another. This phenomenon, known as clonal interference, ensures that those beneficial mutations that do achieve fixation are of large effect. Clonal interference also increases the time between fixations, thereby slowing the adaptation of asexual populations. The effects of clonal interference were measured in the asexual RNA virus vesicular stomatitis virus; rates and average effects of beneficial mutations were quantified.
Intraclonal variation in RNA viruses: generation, maintenance and consequences
2003
This paper explores the evolutionary implications of the enormous variability that characterizes populations of RNA viruses and retroviruses. It begins by examining the magnitude of genetic variation in both natural and experimental populations. In natural populations, differences arise even within individual infected patients, with the per-site nucleotide diversity at this level ranging from <1% to 6%. In laboratory populations, two viruses sampled from the same clone differed by ∼0.7% in their fitness. Three different mechanisms that may be important in maintaining viral genetic variability were tested: (1) Fisher's fundamental theorem, to compare the observed rate of fitness change with …