Search results for "interval"
showing 10 items of 1703 documents
Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study
2021
Abstract It is still unclear how genetic information, provided as single‐nucleotide polymorphisms (SNPs), can be most effectively integrated into risk prediction models for coronary heart disease (CHD) to add significant predictive value beyond clinical risk models. For the present study, a population‐based case‐cohort was used as a trainingset (451 incident cases, 1488 noncases) and an independent cohort as testset (160 incident cases, 2749 noncases). The following strategies to quantify genetic information were compared: A weighted genetic risk score including Metabochip SNPs associated with CHD in the literature (GRSMetabo); selection of the most predictive SNPs among these literature‐co…
A Pooled Analysis of Extremely Low-Frequency Magnetic Fields and Childhood Brain Tumors
2010
Pooled analyses may provide etiologic insight about associations between exposure and disease. In contrast to childhood leukemia, no pooled analyses of childhood brain tumors and exposure to extremely low-frequency magnetic fields (ELF-MFs) have been conducted. The authors carried out a pooled analysis based on primary data (1960–2001) from 10 studies of ELF-MF exposure and childhood brain tumors to assess whether the combined results, adjusted for potential confounding, indicated an association. The odds ratios for childhood brain tumors in ELF-MF exposure categories of 0.1–<0.2 μT, 0.2–<0.4 μT, and ≥0.4 μT were 0.95 (95% confidence interval: 0.65, 1.41), 0.70 (95% CI: 0.40, 1.22), and 1.1…
Hematopoietic and lymphatic cancers in patients with periodontitis : a systematic review and meta-analysis
2019
Background Numerous studies have explored the correlation of periodontal disease (PD) with risk of hematopoietic and lymphatic cancers, but the findings were inconsistent. Therefore, we did a meta-analysis to ascertain the correlation of PD with risk of incident hematopoietic and lymphatic cancers. Material and Methods The authors searched relevant studies in databases (PubMed, Web of Science, and MEDLINE). The summary relative risk (RR) along with 95% confidence interval (CI) was calculated by use of random or fixed effects models. Results Six studies were included in qualitative synthesis. The pooled analysis revealed that PD was significantly associated with an increased risk of hematopo…
Stage IV breast cancer: a population-based study about prognostic factors according to HER2 and HR status
2015
International audience; We aim to describe trends in net survival (NS) and to assess the prognostic factors among women with de novo metastatic breast cancer (MBC) according to human epidermal growth factor receptor 2 (HER2) and hormone receptor (HR) status. Data on women suffering from de novo MBC and diagnosed from 1998 to 2009 were provided by the Côte-d'Or breast cancer registry. NS was described using the Pohar Perme estimator and prognostic factors were investigated in a generalised linear model. We identified 232 patients (mean age = 64.7). Median NS was 29.2 months, 1- and 5-year NS were 76% and 26% respectively. The survival trend in patients with HER2-positive tumours who did not …
Long-Term Efficacy of Maintenance Therapy for Multiple Myeloma: A Quantitative Synthesis of 22 Randomized Controlled Trials
2018
We aimed to quantitatively synthesize data from randomized controlled trials (RCTs) concerning maintenance for multiple myeloma (MM). We searched electronic literature databases and conference proceedings to identify relevant RCTs. We selected eligible RCTs using predefined selection criteria. We conducted meta-analysis comparing maintenance containing new agents and conventional maintenance, and subgroup analysis by transplantation status and mainstay agent as well. We performed trial sequential analysis (TSA) to determine adequacy of sample size for overall and subgroup meta-analyses. We performed network meta-analysis (NMA) to compare and rank included regimens. A total of 22 RCTs involv…
Lymphoma Symptoms: Data from a Phase 3, International, Randomized, Open-Label, Multicenter Study in Patients with Previously Treated Mantle Cell Lymp…
2015
Abstract Introduction MCL is an incurable aggressive B-cell lymphoma with a poor overall prognosis. For patients with MCL who fail initial therapy (ie, with relapsed or refractory [R/R] disease), treatment options historically have been limited. While remission duration is generally short, the goal of therapy has been to achieve remission while balancing treatment-related toxicities. Consequently, a substantial proportion of patients continuously suffer from lymphoma symptoms and other disease signs, such as itching and trouble sleeping or concentrating. Additionally, worries and high emotional sensitivity lead to reduced functional status and well-being. Therefore, it is crucial to any tre…
The Assessment of Second Primary Cancers (SPCs) in a Series of Splenic Marginal Zone Lymphoma (SMZL) Patients
2006
The purpose of this study is to estimate the risk of second primary cancer (SPC) in 129 consecutive patients with splenic marginal zone lymphoma (SMZL) diagnosed in three Italian haematological centres. The person-years method deriving as a sum of products of age- and sex- specific rates and of the corresponding time at risk was used. The SPC Standardized Incidence Ratio (SIR) was 2.03 with a 95% confidence interval: [1.05, 3.56] (p < 0.05) and the corresponding Absolute Excess Risk (AER) was 145.8 (per 10000 SMZL patients per year). Our findings evidence a high frequency of additional cancers in patients with SMZL and suggest that the incidence rate of SPCs is significantly different from …
Beyond psychology: prevalence of p value and confidence interval misinterpretation across different fields
2020
P values and confidence intervals (CIs) are the most widely used statistical indices in scientific literature. Several surveys have revealed that these two indices are generally misunderstood. However, existing surveys on this subject fall under psychology and biomedical research, and data from other disciplines are rare. Moreover, the confidence of researchers when constructing judgments remains unclear. To fill this research gap, we surveyed 1,479 researchers and students from different fields in China. Results reveal that for significant (i.e., p < .05, CI does not include zero) and non-significant (i.e., p > .05, CI includes zero) conditions, most respondents, regardless of acade…
IOWA Operators and Its Application to Image Retrieval
2014
This paper presents a relevance feedback procedure based on logistic regression analysis. Since, the dimension of the feature vector associated to each image is typically larger than the number of evaluated images by the user, different logistic regression models have to be fitted separately. Each fitted model provides us with a relevance probability and a confidence interval for that probability. In order to aggregate these set of probabilities and confidence intervals we use an IOWA operator. The results will show the success of our algorithm and that OWA operators are an efficient and natural way of dealing with this kind of fusion problems.
Sequential visual reaction times
1988
The reaction-time to a series of successive digits was measured on two subjects. After practice, it was found that whilst the reaction time to the onset of the series was constant at 150 ms, the response time to additional digits became less and less to asymptote to a level of about 50 ms. The time course of this ‘chorus-line’ phenomenon was studied in greater temporal detail by varying the interval in steps of 20 ms. The effect was greatest at 200 ms. Thereafter, it declined and for long intervals reached the value of a standard reaction time. On a third inexperienced subject, the learning period was established; this was about 300–400 presentations. The implications of these findings are …