Search results for "iom"
showing 10 items of 14211 documents
Longitudinal Gait Analysis of a Transfemoral Amputee Patient: Single-Case Report from Socket-Type to Osseointegrated Prosthesis
2023
The aim of the present case report was to provide a longitudinal functional assessment of a patient with transfemoral amputation from the preoperative status with socket-type prosthesis to one year after the osseointegration surgery. A 44 years-old male patient was scheduled for osseointegration surgery 17 years after transfemoral amputation. Gait analysis was performed through 15 wearable inertial sensors (MTw Awinda, Xsens) before surgery (patient wearing his standard socket-type prosthesis) and at 3-, 6-, and 12-month follow-ups after osseointegration. ANOVA in Statistical Parametric Mapping was used to assess the changes in amputee and sound limb hip and pelvis kinematics. The gait symm…
Evolutionary advantage conferred by an eukaryote-to-eukaryote gene transfer event in wine yeasts
2015
Although an increasing number of horizontal gene transfers have been reported in eukaryotes, experimental evidence for their adaptive value is lacking. Here, we report the recent transfer of a 158-kb genomic region between Torulaspora microellipsoides and Saccharomyces cerevisiae wine yeasts or closely related strains. This genomic region has undergone several rearrangements in S. cerevisiae strains, including gene loss and gene conversion between two tandemly duplicated FOT genes encoding oligopeptide transporters. We show that FOT genes confer a strong competitive advantage during grape must fermentation by increasing the number and diversity of oligopeptides that yeast can utilize as a s…
Identification of Energy Hubs for the Exploitation of Residual Biomass in an Area of Western Sicily
2017
Recent years have witnessed a marked reduction in financial incentives for renewable energy production in Italy as a consequence of the fact that the nation has already reached its energy policy targets for 2020, However, incentives still persist in certain sectors, such as those of specialized crops for biomass and residual biomass. In order to increase use-efficiency of biomass resources, careful study is needed of their characteristics, and their distribution within an area and over time: biomass use is of interest when production is concentrated in a given area and sufficiently available throughout the year. In order to assess the competitiveness of the biomass energy sector, the logist…
An Overview on the Use of miRNAs as Possible Forensic Biomarkers for the Diagnosis of Traumatic Brain Injury
2023
Determining the cause of death is one of the main goals of forensic pathology. However, conditions can occur in which common approaches—external inspection, autopsy, histology, etc.—might not be conclusive. With the advancement of molecular biology, several investigative techniques have been developed over the years, and the application as approaches complementary to routine procedures has proved useful in these cases. In this context, microRNA (miRNA) profiling has attracted increasing interest due to these molecules’ ability to regulate physiological and pathological processes. The evidence of differential miRNA expression in both animal models and human samples of traumatic brain injury …
Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial
2022
Background and purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options. RNS60 is an immunomodulatory and neuroprotective investigational product that has shown efficacy in animal models of ALS and other neurodegenerative diseases. Its administration has been safe and well tolerated in ALS subjects in previous early phase trials. Methods: This was a phase II, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial. Participants diagnosed with definite, probable or probable laboratory-supported ALS were assigned to receive RNS60 or placebo administered for 24 weeks intravenously (375 ml) once a week and via nebul…
The nexus between big data and sustainability: an analysis of current trends and developments
2021
[EN] With the development of technological innovations, Big Data is transforming the socioeconomic world, impacting almost every organization and person. The transformations associated with the development of Big Data have important consequences for the sustainability of organizations, regions, and the society as a whole, and as such, they have been specifically addressed by the academic literature focusing on sustainability. Despite its importance, and perhaps because of its rapid emergence, there is a lack of studies dealing with the analysis of this body of literature and its trends. The current research attempts to fill this gap. The study develops a bibliometric and visualization analy…
Tuottaako pohjoismainen malli hyvää työelämän laatua vielä tulevaisuudessakin?
2017
Pohjoismaat ovat perinteisesti erottuneet työelämän laatuvertailuissa Euroopan ykkösinä. Taustalla vaikuttavat työmarkkinoiden palveluvaltaisuus ja korkea työvoiman osaamistaso, mutta myös erilaiset institutionaaliset tekijät, kuten työmarkkinoiden sääntely, ammattiyhdistysliikkeen asema ja sosiaalipoliittiset ratkaisut. Työelämän laatu voi kuitenkin heikentyä, kun näitä ankkureita kierretään tai kun ne eivät tavoita kaikkien alojen työntekijöitä. Organisaatioiden uudelleenjärjestelyt, ulkoistaminen ja alihankinta sekä uusien alojen ja työnteon uusien muotojen syntyminen saattavat heikentää työelämän laatua. nonPeerReviewed
Evaluación y caracterización biomecánica de los trinquetes de pelota valenciana. (Biomechanical assessment and characterization of the Valencian ball…
2012
El trinquete es la instalacion de referencia en la practica de la pelota valenciana, donde se juegan las modalidades profesionales de escala i corda y raspall. Sin embargo, no existe una normativa ni procedimientos de ensayo especificos que permitan definir las caracteristicas mecanicas que deben reunir paredes y pavimento del trinquete, para que los jugadores tengan una practica segura y optimicen su rendimiento. El objetivo de este estudio fue analizar diferentes variables mecanicas en las instalaciones de juego, determinar los procedimientos de ensayo mas adecuados y, finalmente, proponer unos valores mecanicos que definan una instalacion de calidad. Los estudios se llevaron a cabo en 10…
Biohajoavien ja biostabiilien polymeerien aiheuttamat pehmytkudosreaktiot
2007
Extracellular Vesicles as Shuttles of Tumor Biomarkers and Anti-Tumor Drugs
2014
Extracellular vesicles (EV) include vesicles released by either normal or tumor cells. EV may exceed the nanometric scale (microvesicles), or to be within the nanoscale, also called exosomes. Thus, it appears that only exosomes and larger vesicles may have the size for potential applications in nanomedicine, in either disease diagnosis or therapy. This is of particular interest for research in cancer, also because the vast majority of existing data on EV are coming from pre-clinical and clinical oncology. We know that the microenvironmental features of cancer may favor cell-to-cell paracrine communication through EV, but EV have been purified, characterized, and quantified from plasma of tu…