Search results for "ion channel"
showing 10 items of 567 documents
Computational methods and theory for ion channel research
2022
Ion channels are fundamental biological devices that act as gates in order to ensure selective ion transport across cellular membranes; their operation constitutes the molecular mechanism through which basic biological functions, such as nerve signal transmission and muscle contraction, are carried out. Here, we review recent results in the field of computational research on ion channels, covering theoretical advances, state-of-the-art simulation approaches, and frontline modeling techniques. We also report on few selected applications of continuum and atomistic methods to characterize the mechanisms of permeation, selectivity, and gating in biological and model channels.
Time-Frequency Characteristics of In-Home Radio Channels Influenced by Activities of the Home Occupant
2019
While aging is a serious global concern, in-home healthcare monitoring solutions are limited to context-aware systems and wearable sensors, which may easily be forgotten or ignored for privacy and comfort reasons. An emerging non-wearable fall detection approach is based on processing radio waves reflected off the body, who has no active interaction with the system. This paper reports on an indoor radio channel measurement campaign at 5.9 GHz, which has been conducted to study the impact of fall incidents and some daily life activities on the temporal and spectral properties of the indoor channel under both line-of-sight (LOS) and obstructed-LOS (OLOS) propagation conditions. The time-frequ…
Humanities and Social Sciences Latvia. Vol. 25, N. 2 (Autumn-Winter 2017)
2017
Group Buying of Competing Retailers
2011
'TRPing' synaptic ribbon function in the rat pineal gland: neuroendocrine regulation involves the capsaicin receptor TRPV1.
2009
Synaptic ribbons (SRs) are presynaptic structures thought to regulate and facilitate multivesicular release. In the pineal gland, they display a circadian rhythm with higher levels at night paralleling melatonin synthesis. To gain more insight into the processes involved and the possible functions of these structures, a series of experiments were conducted in rodents. We studied the regional distribution of a molecular marker of pineal SRs, the kinesin motor KIF3A in the gland. Respective immunoreactivity was abundant in central regions of the gland where sympathetic fibers were less dense, and vice versa, revealing that intercellular communication between adjacent pinealocytes is enhanced …
Efficient Power Allocation for Multi-Cell Uplink NOMA Network
2019
Digital technologies are rapidly shaping the modern concepts of urbanization. It is a key element of developing practical smart cities of the future. In fact, they are the catalyst for the increasing networking of all areas of life in a smart city. Recent development in the domain of communication technologies has opened new avenues to realize the concept of smart cities. One of such communication technology is non-orthogonal multiple access (NOMA) for future cellular communications. This article, therefore, focuses on the interference management of uplink cellular NOMA systems. Specifically, we propose a power optimization technique for NOMA to improve the sum-rate in a multi-cell environm…
A game theoretic approach to MAC design for infrastructure networks
2010
Wireless network operation intrinsically assumes different forms of cooperation among the network nodes, such as sharing a common wireless medium without interfering, relaying frames belonging to other nodes, controlling the transmission power for optimizing spectrum reuse, coding cooperatively multiple frames for improving information redundancy, and so on. For this reason, Game Theory has been extensively employed to model wireless networks. In particular, we propose a game-theoretic approach for defining a generalized medium access protocol for slotted contention-based channels. Contention-based channels are largely adopted in data networks, e.g. in WiFi and WiMax networks and in some em…
Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors.
1999
The assembly of signalling molecules into macromolecular complexes (transducisomes) provides specificity, sensitivity and speed in intracellular signalling pathways. Rod photoreceptors in the eye contain an unusual set of glutamic-acid-rich proteins (GARPs) of unknown function. GARPs exist as two soluble forms, GARP1 and GARP2, and as a large cytoplasmic domain (GARP' part) of the beta-subunit of the cyclic GMP-gated channel. Here we identify GARPs as multivalent proteins that interact with the key players of cGMP signalling, phosphodiesterase and guanylate cyclase, and with a retina-specific ATP-binding cassette transporter (ABCR), through four, short, repetitive sequences. In electron mic…
AMPA Receptor Auxiliary Proteins of the CKAMP Family
2019
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are assembled of four core subunits and several additional interacting proteins. Cystine-knot AMPA receptor-modulating proteins (CKAMPs) constitute a family of four proteins that influence the trafficking, subcellular localization and function of AMPA receptors. The four CKAMP family members CKAMP39/shisa8, CKAMP44/shisa9, CKAMP52/shisa6 and CKAMP59/shisa7 differ in their expression profile and their modulatory influence on AMPA receptor function. In this review, I report about recent findings on the differential roles of CKAMP family members.