Search results for "juvenile"

Protracted juvenile neuronal ceroid-lipofuscinosis.

1993

Dementia in the Neuronal Ceroidlipofuscinoses

2001

Dementia is defined as a decline in cognitive abilities such as impairment of memory, reasoning, behaviour, attention, motivation and effectiveness. The term usually implies that normal mature mental capability was achieved before, and it is therefore mostly ascribed to adult patients.

HLA antigens and immunoresponsiveness to insulin in insulin-dependent diabetes mellitus.

2008

HLA-A and B antigens were determined in 112 patient with insulin-dependent juvenile onset diabetes mellitus, who could be subdivided into “non” and “high responders” to insulin. The data revealed a trend of an association of these diabetes subgroups with only one of the diabetes-associated antigens HLA-B8 and HLA-BW15 and indicated the existence of at least two different genetic constellations for susceptibility to juvenile diabetes mellitus. One form with a strong immune-response to insulin seemed to be associated with HLA-BW 15 and the other form without humoral immunoreactivity to insulin seemed to be associated with the presence of HLA-B8 and the absence of HLA-B7.

Postembryonic development of Zophobas atratus Fab. (Coleoptera: Tenebrionidae) under crowded or isolated conditions and effects of juvenile hormone a…

1995

Abstract Pupation in Zophobas atratus is dependent on isolation and this provides a model for study of the onset of metamorphosis in beetles. We have analyzed the effects of isolation vs grouping on certain developmental parameters; the number of larval instars; their duration and weight. Sex differences were detected, such as the occurrence of regressive moults in females. Moreover, the development of Z. atratus is discussed in relation to Tenebrio molitor , the physiological timing of which appeared in part extendable to Z. atratus . Experiments show that 4–6 days of isolation are required for commencement of metamorphosis, as indicated by an immobile crooked posture observed at the end o…

Field application of the juvenile hormone analogue fenoxycarb against hopper bands of Locusta migratoria capito in Madagascar

1997

Summary Field trials have been carried out to examine the suitability of the JHA fenoxycarb in locust control. Laboratory tests have shown that a variety of JHAs, including fenoxycarb, applied to last instar larvae increased mortality, induced morphogenetic defects during metamorphosis, reduced fertility and provoked solitarisation of gregarious hoppers. The phase shift was indicated by green coloration and the acquisition of morphological and behavioural characteristics typical for solitary locusts. The present field experiments should clarify whether or not the effects observed in the laboratory are also observed with hopper bands in their natural habitat and if swarm formation and emigra…

Canakinumab in systemic juvenile idiopathic arthritis: real-world data from a retrospective Italian cohort

2021

Abstract Objective The objective of this study was to use real-world data to evaluate the effectiveness and safety of canakinumab in Italian patients with systemic JIA (sJIA). Methods A retrospective multicentre study of children with sJIA was performed. Clinical features, laboratory parameters and adverse events were collected at baseline, and 6 and 12 months after starting canakinumab. The primary outcome measure of effectiveness was clinically inactive disease (CID) off glucocorticoids (GCs) treatment at 6 months. Results A total of 80 children from 15 Italian centres were analysed. Of the 12 patients who started canakinumab in CID while receiving anakinra, all maintained CID. Of the 68 …

Image of the Month—Quiz Case

2008

Juvenile Rheumatoid Arthritis and Still’s Disease

1975

In the Anglo-American literature, the term “Still’s disease”, based on the observations of ○Cornil (1864) and Still (1897) is generally employed to cover the juvenile forms of rheumatoid arthritis, defined by Ansell and Bywaters (1959). German paediatricians, on the other hand, particularly Storber and Kolle, regard Still’s disease as a separate syndrome. Kolle uses the following characteristics for this distinction: 1. High fever at the commencement of illness. 2. Enlargement of lymph nodes, spleen and liver. 3. Myocarditis and pericarditis. 4. High leucocyte count. 5. Erythema multiforme in about 70% of patients.

PReS-FINAL-2088: Risk of severe adverse events in juvenile idiopathic arthritis and pediatric-onset inflammatory bowel disease, treated with anti-tnf…

2013

Introduction: Severe adverse events have been described in children affected by Juvenile Idiopathic Arthritis (JIA) and Inflammatory Bowel Disease (IBD) treated with anti-tnf drugs. Objectives: To define the risk of severe adverse events in patients with JIA and IBD treated with anti-tnf drugs. Methods: This is a retrospective cohort study. All patients with JIA and IBD attending the "IRCCS Burlo Garofolo" of Trieste from 2000 to 2012 were enrolled. They were divided into 2 groups on the basis of the presence or absence of anti-tnf exposure. Severe adverse events were considered the followings: a) infections needing anti-tnf permanent suspension and/or hospitalization; b) autoimmune disease…

Osmophobia in migraine classification: a multicentre study in juvenile patients.

2010

Aims: This study was planned to investigate the diagnostic utility of osmophobia as criterion for migraine without aura (MO) as proposed in the Appendix (A1.1) of the International Classification of Headache Disorders (ICHD-II, 2004). Methods: We analysed 1020 patients presenting at 10 Italian juvenile headache centres, 622 affected by migraine (M) and 328 by tension-type headache (TTH); 70 were affected by headache not elsewhere classified (NEC) in ICHD-II. By using a semi-structured questionnaire, the prevalence of osmophobia was 26.9%, significantly higher in M than TTH patients (34.6% vs 14.3%). Results: Osmophobia was correlated with: (i) family history of M and osmophobia; and (ii) o…