Search results for "kemia"
showing 10 items of 1521 documents
Project-Based Education Research Course Supports Exchange-students’ Research Minded Teacher Identity
2022
Project-based education (PBE) gives possibilities for students to work together and feeling of belonging in a community even during distance learning. At the Department of Chemistry, University of Jyväskylä (JYU), a group of exchange students participated in a PBE chemistry teacher education research course online. The goal of the course was to enforce the connection between research on science teaching and acting sustainable in society. This study is based on semi-structured online group interview of the students after this PBE course. The main focus of this investigation was how positive feelings and attitude affect learning. peerReviewed
How can networks help encourage the development and professionalisation of innovative early STEM Education in a changing world?
2023
Maailma muuttuu monimutkaisemmaksi ja vaatii muun muassa STEM*-osaamista ja lukutaitoa oppijoilta, yhteisön jäseniltä ja yhteiskunnilta. Siksi laadukkaalle varhaiselle STEM-koulutukselle tarvitaan laajaa puolustamista. Tässä artikkelissa hahmotellaan, kuinka vaikutusverkostot (joita on muodostettu käsittelemään monimutkaisia sosiaalisia tai ympäristökysymyksiä) voivat edistää varhaisen STEM-koulutuksen kehittämistä ja ammattimaistumista. Sen tavoitteena on tukea alaa kehittäviä oppilaitoksia lisäämään työnsä vaikutusta paremman ja helposti saavutettavan koulutuksen puolesta maailmanlaajuisesti. Tutkittuaan varhaisen STEM-koulutuksen suunniteltuja vaikutuksia nykyisessä kontekstissa esitellä…
Elinympäristöön liittyvä analytiikka yliopisto-opetuksessa
2014
Tutkielmassa käydään läpi vesianalyysin vaiheita sekä menetelmiä, ja niitä tarkastellaan yliopisto-opintoihin soveltuvuuden pohjalta. Tämän lisäksi työssä esitellään projektioppimisen menetelmä, jota tarkastellaan opetuksen ja oppimisen lähtökohdista. Tutkielman pohjalta luotiin projektioppimiseen pohjautuva analyyttisen kemian laboratoriotyö, jonka toteutus vastaa Jyväskylän yliopiston LuK-tutkinnossa asetettuihin tieteen opetuksen ja oppimisen tavoitteisiin. Näiden tavoitteiden täyttymistä arvioidaan muissa yliopistoissa toteutettujen projektioppimistutkimusten tulosten pohjalta. Näin saadaan selkeä käsitys siitä, mihin oppimistuloksiin oikein toteutetun projektiopetuksen avulla voidaan p…
Exercise as stimulus for cartilage health in knee osteoarthritis
2018
Knee osteoarthritis (OA) is a leading cause of musculoskeletal pain and disability and has significant socio-economical costs globally. There is no known cure for OA. Therapeutic exercise has been shown to evoke acute positive posttreatment effects on pain and function. Even though cartilage degeneration is crucial in OA progression, there is sparse knowledge about exercise effects on osteoarthritic cartilage. The purpose of this study was to investigate the efficacy of aquatic resistance training on the estimated biochemical composition of tibiofemoral cartilage and the association between leisure time physical activity (LTPA) and tibiofemoral cartilage in postmenopausal women with mild kn…
Thermodynamically driven self-assembly of pyridinearene to hexameric capsules
2019
Pyridinearene macrocycles have previously shown unique host–guest properties in their capsular dimers including endo complexation of neutral molecules and exo complexation of anions. Here, we demonstrate for the first time the formation of hydrogen bonded hexamer of tetraisobutyl-octahydroxypyridinearene in all three states of matter – gas phase, solution and solid-state. Cationic tris(bipyridine)ruthenium(II) template was found to stabilize the hexamer in gas phase, whereas solvent molecules do this in condensed phases. In solution, the capsular hexamer was found to be the thermodynamically favoured self-assembly product and transition from dimer to hexamer occurred in course of time. The …
Role of Weak Hydrogen Bonds and Halogen Bonds in 5-Halo-1,3-dimethyluracils and Their Cocrystals : A Combined Experimental and Computational Study
2016
Seven single crystals containing either N,N-dimethyluracil (DMHU) or one of its 5-halogenated derivatives (DMXU; X = F, Cl, Br, I) were prepared using N,N-dimethylformamide as the crystallization solvent. Single crystal X-ray diffraction and quantum chemical calculations carried out at the spin component scaled local MP2 level of theory were then used to study the intramolecular halogen and nonconventional hydrogen bonds present in the structures. The results were compared to and contrasted with the previously reported data for uracil and its halogenated derivatives. In particular, the intermolecular interactions in DMIU were compared to the halogen and hydrogen bonds in 5-iodouracil that, …
Nuclear localization but not PML protein is required for incorporation of the papillomavirus minor capsid protein L2 into virus-like particles.
2004
ABSTRACT Recent reports suggest that nuclear domain(s) 10 (ND10) is the site of papillomavirus morphogenesis. The viral genome replicates in or close to ND10. In addition, the minor capsid protein, L2, accumulates in these subnuclear structures and recruits the major capsid protein, L1. We have now used cell lines deficient for promyelocytic leukemia (PML) protein, the main structural component of ND10, to study the role of this nuclear protein for L2 incorporation into virus-like particles (VLPs). L2 expressed in PML protein knockout (PML −/− ) cells accumulated in nuclear dots, which resemble L2 aggregates forming at ND10 in PML protein-containing cells. These L2 assemblies also attracted…
Quantitative microscopy reveals stepwise alteration of chromatin structure during herpesvirus infection
2019
During lytic herpes simplex virus 1 (HSV-1) infection, the expansion of the viral replication compartments leads to an enrichment of the host chromatin in the peripheral nucleoplasm. We have shown previously that HSV-1 infection induces the formation of channels through the compacted peripheral chromatin. Here, we used three-dimensional confocal and expansion microscopy, soft X-ray tomography, electron microscopy, and random walk simulations to analyze the kinetics of host chromatin redistribution and capsid localization relative to their egress site at the nuclear envelope. Our data demonstrated a gradual increase in chromatin marginalization, and the kinetics of chromatin smoothening arou…
Systematic study of SYBR green chromophore reveals major improvement with one heteroatom difference
2021
Five nucleic acid binding cyanine dyes were synthesized and their photophysical properties were evaluated. Changing a single heteroatom in the chromophore causes major differences both in brightness and photostability between the dyes. With such alteration, the brightness of the chromophore increased two-fold compared to the one found in SYBR Green I. peerReviewed
On-chip purification of arc-discharge synthesized multiwalled carbon nanotubes via mobile liquid interface
2017
This thesis reports a novel approach for purification of carbon nanotube (CNT) samples deposited on smooth silicon substrates through a mobile liquid interface interacting with carbonaceous debris particles that contaminate the deposition. The method is based on physical interaction of the particles and the three-phase contact line via capillary interface forces, i.e. the surface tension, which results in the detachment of chemically indispersible colloids from the sample surface. In the experiments reported in this work, we focus primarily on arc-discharge grown multi-walled carbon nanotubes, whose synthesis is particularly plagued by carbonaceous debris that is difficult to remove without h…