Search results for "keratocyst"
showing 10 items of 38 documents
Histological changes in odontogenic parakeratinized keratocysts treated with marsupialization followed by enucleation
2020
Background The purpose of this study was to evaluate whether marsupialization treatment induces changes in the histology of odontogenic keratocyst epithelium and to compare our experience with the literature. Material and Methods A retrospective revision of histological samples was performed. 5 patients with odontogenic keratocyst treated with marsupialization follow by enucleation were selected. Histologic evaluation analyzed the changes in the keratocyst epithelium after marsupialization in terms of type of keratinization, thickness of the epithelium and connective tissue, the presence of acanthosis, the presence and grade of fibrosis, the type and grade of inflammation and the presence a…
Immunohistochemical expression of glucose transporter 1 in keratin-producing odontogenic cysts
2016
Background: Keratin-producing odontogenic cysts (KPOCs) are a group of cystic lesions that are often aggressive, with high rates of recurrence and multifocality. KPOCs included orthokeratinised odontogenic cyst (OOC) and parakeratotic odontogenic cysts, which are now considered true tumours denominated keratocystic odontogenic tumours (KCOTs). GLUT1 is a protein transporter that is involved in the active uptake of glucose across cell membranes and that is overexpressed in tumours in close correlation with the proliferation rate and positron emission tomography (PET) imaging results. Methods: A series of 58 keratin-producing odontogenic cysts was evaluated histologically and immunohistochemi…
Apoptosis and cell cycle aberrations in epithelial odontogenic lesions : an evidence by the expression of p53, Bcl-2 and Bax
2017
Background Ameloblastoma (AMB), odontogenic keratocyst (OKC) and adenomatoid odontogenic tumor (AOT) are epithelial odontogenic lesions with diverse biologic profiles. Defects in regulation of apoptosis and cell cycle may be involved in the development and progression of those lesions, therefore we aimed to investigate the expression of Bcl-2, Bax and p53 to better understand the possible role of these proteins in AMBs, OKCs and AOTs. Material and Methods The studied sample consisted of 20 AMBs, 20 OKCs and 20 AOTs. Immunohistochemistry technique was performed for the antibodies p53, Bcl-2 and Bax. Immunoreactivity was observed in the epithelial component and positive cells were counted in …
Diagnóstico diferencial inmunomorfológico de las lesiones quísticas maxilares con queratinización
2011
ResumenObjetivosLos quistes maxilares con queratinización son formas lesionales de carácter controvertido y de relevancia clínica, dada la implicación clínico-evolutiva del llamado tumor odontogénico queratoquístico (TOQ). En el presente estudio nos planteamos valorar la utilidad de las técnicas inmunohistoquímicas en la identificación de estas lesiones.Material y métodosSe analizan de forma retrospectiva las lesiones quísticas maxilares dotadas de fenómenos de queratinización interna, diagnosticadas en un mismo centro hospitalario, a lo largo de un periodo de 4 años, realizando un estudio inmunohistoquímico mediante la aplicación de un panel de cinco anticuerpos (Ki67, Bcl-2, p53, CK19, D2…
Evaluation of the primary stability in dental implants placed in low density bone with a new drilling technique, osseodensification: an in vitro study
2020
Background Primary stability is an important key determinant of implant osseointegration. We investigated approaches to improve primary implant stability using a new drilling technique termed osseodensification (OD), which was compared with the conventional under-drilling (UD) method utilized for low-density bones. Material and Methods We placed 55 conical internal connection implants in each group, in 30 low-density sections of pig tibia. The implants were placed using twist drill bits in both groups; groups Under Drilling (UD) and Osseodensification (OD) included bone sections subjected to conventional UD and OD drilling, respectively. Before placing the implants, we randomized the bone s…
Accuracy of computer-aided image analysis in the diagnosis of odontogenic cysts: A systematic review
2020
Background This study aimed to search for scientific evidence concerning the accuracy of computer-assisted analysis for diagnosing odontogenic cysts. Material and Methods A systematic review was conducted according to the PRISMA statements and considering eleven databases, including the grey literature. Protocol was registered in PROSPERO (CRD 42020189349). The PECO strategy was used to define the eligibility criteria and only studies involving diagnostic accuracy were included. Their risk of bias was investigated using the Joanna Briggs Institute Critical Appraisal tool. Results Out of 437 identified citations, five papers, published between 2006 and 2019, fulfilled the criteria and were i…
Prosthetic rehabilitation with dental implants after treatment of a keratocystic odontogenic tumor. Case report
2011
Keratocystic odontogenic tumor (KCOT), formerly known as the odontogenic keratocyst (OKC) is a benign intraosseous lesion, characterized by invasive growth and high rate of recurrences. Although it is not frequently seen, KCOT may be associated with unerupted teeth and without relevant histopathological examinations, might be mistaken with dentigerous cyst. A 26 year-old male patient referred to our department with complaints of two months persisting painless swelling on the left side of mandible. Clinical and radiographic examinations revealed an impaction of the horizontally positioned left lower second premolar surrounded by a well-circumscribed radiolucent mass, located between the left…
Primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst: case series and literature review
2020
Background The aim of this study was to investigate the clinicopathologic features of primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst (PIOSCC ex OKC) and comprehensively improve the understanding of this disease. Material and Methods We retrospectively investigated five cases of PIOSCC ex OKC at Peking University School and Hospital of Stomatology. We also conducted a systematic review of studies on PIOSCC ex OKC by using online databases from their inception until February 2020. Results In our series of five cases, all lesions were located in the mandible. Three cases (60%) showed recurrent OKCs and two cases (40%) showed primary OKCs. During the follow-…
Peripheral odontogenic keratocyst: Report of two new cases and review of the literature
2020
Peripheral odontogenic keratocyst (POKC) is a rare soft tissue entity showing the same histological characteristics of odontogenic keratocyst. Herein, we report two cases of POKC affecting the gingiva/alveolar mucosa. Case 1. A 43-year-old female was referred for evaluation of a painless well-defined nodular, sessile, non-tender swelling in the right maxillary buccal gingiva. No radiological alterations were observed. The patient was submitted to excisional biopsy and histological diagnosis was POKC. There were no signs of local recurrence after a 4-year follow-up. Case 2. A 63-year-old female was referred for evaluation of a painless well-defined nodular, sessile, yellowish swelling in the…
Simple bone cyst : a case report
2021
Background Simple bone cysts (SBC) are intraosseous cysts devoid of an epithelial lining, asymptomatic and appearing in the jaw. In general, SBCs are discovered incidentally and tooth displacement or pathological fractures are very unusual. Material and methods This study reports a 16 years old man that presented an asymtomatic radiolucent unilocular lesion in the right ascending ramus. Differencial diagnosis included odontogenic keratocyst and dentigerous cyst. One surgical intervention was performed and consisted in the curettage of the bone walls. The lesion and some small samples of the bone wall were sent for the anatomopathological study. Results The anatomopathological exam confirmed…