Search results for "koe-eläinmallit"
showing 5 items of 15 documents
Rats with elevated genetic risk for metabolic syndrome exhibit cognitive deficiencies when young
2021
Metabolic syndrome (MetS) is a known risk factor for cognitive decline. Using polygenic rat models selectively bred for high and low intrinsic exercise capacity and simultaneously modelling as low and high innate risk factor for MetS respectively, we have previously shown that adult animals with lower exercise capacity/higher MetS risk perform poorly in tasks requiring flexible cognition. However, it is not known whether these deficits in cognition are present already at young age. Also, it is unclear whether the high risk genome is related also to lower-level cognition, such as sensory gating measured as prepulse inhibition. In this study, young and adult (5-8 weeks and ∼9 months) rats sel…
Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats
2023
Good aerobic fitness associates positively with cognitive performance and brain health and conversely, low aerobic fitness predisposes to neurodegenerative diseases. To study how genotype together with exercise, started at older age, affects brain and behavior, we utilized rats that differ in inherited aerobic fitness. Rats bred for Low Capacity for Running (LCR) are shown to display less synaptic plasticity and more inflammation in the hippocampus and perform worse than rats bred for a High Capacity for Running (HCR) in tasks requiring flexible cognition. Here we used middle-aged (∼ 16 months) HCR and LCR rats to study how genotype and sex associate with anxiety and neural information filt…
Deviance detection in sound frequency in simple and complex sounds in urethane-anesthetized rats
2019
Mismatch negativity (MMN), which is an electrophysiological response demonstrated in humans and animals, reflects memory-based deviance detection in a series of sounds. However, only a few studies on rodents have used control conditions that were sufficient in eliminating confounding factors that could also explain differential responses to deviant sounds. Furthermore, it is unclear if change detection occurs similarly for sinusoidal and complex sounds. In this study, we investigated frequency change detection in urethane-anesthetized rats by recording local-field potentials from the dura above the auditory cortex. We studied change detection in sinusoidal and complex sounds in a series of …
High-intensity interval training and moderate intensity training with exogenous adenosine counteract development of obesity in rats
2022
Objectives High-Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) can combat the obesity epidemic. However, studies comparing their effects on obesity show controversial findings regarding weight loss. Adenosine has emerged as a possible, novel therapeutic agent to treat obesity, but more preclinical studies on its efficacy are needed. Therefore, the objectives of this study were to compare the effects of HIIT and MIT on obesity, and further to determine the dose-dependent effects of adenosine on body weight. Equipment and methods We induced obesity in male Wistar rats with high-fat diet (HFD) and monitored development of obesity by comparing the weight to rats on nor…
Sosiaalinen oppiminen eläinmallissa
2016
Tässä kokeellisessa tutkimuksessa tarkasteltiin sosiaalista oppimista eläinmallissa, jonka keskiössä olivat rotat ja niiden oppimisen sosiaalisuus. Tätä ilmiötä lähestyttiin pohtimalla kysymyksiä: (1) eroavatko rotat lajikannan (HCR - LCR) tai (2) oppimistyylin (itsenäinen - toiselta mallintava) suhteen, sekä (3) eroavatko viivästetyn ja viiveettömän sosiaalisen oppimisen ryhmät toisistaan. Toisin sanoen tutkimuksessa sosiaalinen oppiminen miellettiin rottien käyttäytymisessä tapahtuviksi muutoksiksi, joiden mahdollista ilmenemistä voitiin tarkastella useilla mittauskerroilla. Tutkimuksen koeryhmä muodostui urosrotista (N = 18), joissa oli HCR-rottia (n = 10) ja LCR-rottia (n = 8). Koeasete…