Search results for "kr"
showing 10 items of 7011 documents
Abstract 1126: Efficacy of BET bromodomain inhibition in Kras-positive non-small cell lung cancer.
2013
Abstract Amplification of MYC is one of the most common genetic alterations in lung cancer, contributing to a myriad of phenotypes associated with growth, invasion and drug resistance. Murine genetics has established both the centrality of somatic alterations of Kras in lung cancer, as well as dependency of Kras-dependent tumors on c-Myc function. Unfortunately, drug-like small-molecule inhibitors of KRAS and c-Myc have yet to be realized. The recent discovery in hematologic malignancies that bromodomain inhibition impairs MYC expression and MYC-dependent transcriptional function prompted the possibility of targeting KRAS-driven NSCLC with a potent, prototypical BET bromodomain inhibitor, J…
Genomic characterization of undifferentiated sarcomatoid carcinoma of the pancreas
2022
Undifferentiated sarcomatoid carcinoma (USC) of the pancreas is a rare but especially aggressive variant of pancreatic ductal adenocarcinoma (PDAC), composed of at least 80% of sarcomatoid cells. This study aimed to elucidate its clinicopathological and molecular features. The study cohort included 10 patients with pancreatic USC. Clinicopathological parameters were determined for each patient. The molecular profile was investigated using next-generation sequencing (NGS). Histologically, all tumors were hypercellular neoplasms with spindle-shaped or sarcomatoid cells. All patients showed vascular and perineural invasion. Most patients had a poor prognosis. NGS showed important similarities …
Approche géoarchéologique sur la nécropole monumentale d'Escolives-Ste-Camille (Yonne): un site en bordure d'un chenal de l'Yonne à l'époque néolithi…
2006
Die Herausbildung des Mittelneolithikums I Cerny wird im Südosten des Pariser Beckens von dem Auftauchen monumentaler Nekropolen in den Sohlen von Flusstälern begleitet. Die Eingliederung dieser Bestattungsplätze in die Landschaft lässt eine ausdrückliche Absicht erkennen und tradiert möglicherweise den Anspruch einer Gruppe, ihr Gebiet deutlich als das ihre auszuweisen. Vor diesem Hintergrund waren die Ausgrabungen der Nekrolpole von Escolives-Sainte-Camille ‘La Pièce de l'Étang’ von Untersuchungen begleitet, welche die Umgebung des Fundplatzes in neolithischer Zeit bestimmen sollten. Es ging darum, die Einfügung des Platzes zwischen zwei Paläorinnen in ihrem hydrographischen Milieu zu rek…
Gully erosion susceptibility mapping using GIS-based multi-criteria decision analysis techniques
2019
Abstract This research introduces a scientific methodology for gully erosion susceptibility mapping (GESM) that employs geography information system (GIS)-based multi-criteria decision analysis. The model was tested in Semnan Province, Iran, which has an arid and semi-arid climate with high susceptibility to gully erosion. The technique for order of preference by similarity to ideal solution (TOPSIS) and the analytic hierarchy process (AHP) multi-criteria decision-making (MCDM) models were integrated. The important aspect of this research is that it did not require gully erosion inventory maps for GESM. Therefore, the proposed methodology could be useful in areas with missing or incomplete …
Wind speed spatial estimation for energy planning in Sicily: A neural kriging application
2008
Abstract One of the first steps for the exploitation of any energy source is necessarily represented by its estimation and mapping at the aim of identifying the most suitable areas in terms of energy potential. In the field of renewable energies this is often a very difficult task, because the energy source is in this case characterized by relevant variations over space and time. This implies that any temporal, but also spatial, estimation model has to be able to incorporate this spatial and temporal variability. The paper deals with the spatial estimation of the wind fields in Sicily (Italy) by following a data-driven approach. Starting from the results of a preliminary study, a novel tech…
Reconfigurations in sustainability transitions : a systematic and critical review
2021
Two streams of literature have become especially prominent in understanding social change toward sustainability within the past decades: the research on socio-technical transitions and applications of social practice theory. The aim of this article is to contribute to efforts to create dialogue between these two approaches. We do this by focusing on the concept of reconfiguration, which has become a much-used, but poorly defined notion in the discussion on sustainability transitions. To understand what is defined as reconfiguration in systems and practices, and how the understanding of reconfiguration in regimes could benefit from insights about reconfiguration in practices, we conducted a …
Prosocial and Aggressive Behavior Occurrence in Young Athletes: Field Research Results in Six European Countries
2020
Aggression and violence among youth are researched as social phenomena in sport. This paper was designed to determine the occurrence of these behaviors as well as prosocial behaviors among young athletes. The current paper is a research report aiming to detect the frequency of aggressive behavior, social exclusion, prosocial behavior and cohesion in the youth environment, the frequency of personal experience of peer violence or social exclusion, and to evaluate cross-national differences in terms of occurrence of these phenomena.The field research was conducted in six European countries (Austria, Bosnia and Herzegovina, Croatia, Italy, Lithuania, and Serbia) on a sample of 482 children aged…
Vertical stratification of bacteria and archaea in sediments of a small boreal humic lake
2019
ABSTRACT Although sediments of small boreal humic lakes are important carbon stores and greenhouse gas sources, the composition and structuring mechanisms of their microbial communities have remained understudied. We analyzed the vertical profiles of microbial biomass indicators (PLFAs, DNA and RNA) and the bacterial and archaeal community composition (sequencing of 16S rRNA gene amplicons and qPCR of mcrA) in sediment cores collected from a typical small boreal lake. While microbial biomass decreased with sediment depth, viable microbes (RNA and PLFA) were present all through the profiles. The vertical stratification patterns of the bacterial and archaeal communities resembled those in mar…
Integracja muzułmanów i kryzys migracyjny jako wyzwania dla niemieckiej i europejskiej dyplomacji
2016
W artykule przedstawiono problem integracji muzułmanów oraz konsekwencje współczesnego kryzysu migracyjnego, które stoją przed niemiecką i europejską dyplomacją. W odniesieniu do teoretycznych rozważań, przedstawiono koncepcje i modele polityki integracyjnej prowadzonej przez państwa zachodnioeuropejskie w warunkach przed kryzysem i obecnie. W opracowaniu zawarto krótki zarys historii napływu muzułmanów do Niemiec oraz procesy związane z ich integracją. Przedstawiono też główne cechy obecnego kryzysu, wskazując na wyzwania, jakie niesie dla całej Unii, a w szczególności dla Niemiec jako kraju najbardziej zaangażowanego w proces przyjmowania uchodźców i imigrantów. Zwrócono uwagę na podstawo…
New Approaches to OCR for Early Printed Books
2020
Books printed before 1800 present major problems for OCR. One of the main obstacles is the lack of diversity of historical fonts in training data. The OCR-D project, consisting of book historians and computer scientists, aims to address this deficiency by focussing on three major issues. Our first target was to create a tool that identifies font groups automatically in images of historical documents. We concentrated on Gothic font groups that were commonly used in German texts printed in the 15th and 16th century: the well-known Fraktur and the lesser known Bastarda, Rotunda, Textura und Schwabacher. The tool was trained with 35,000 images and reaches an accuracy level of 98%. It can not on…