Search results for "kunta"
showing 10 items of 2870 documents
Moderate exercise in mice improves cancer plus chemotherapy-induced muscle wasting and mitochondrial alterations
2019
Cancer cachexia is a multifactorial syndrome characterized by anorexia, body wasting, and muscle and adipose tissue loss, impairing patient's tolerance to anticancer treatments and survival. The aim of the present study was to compare the effects induced in mice by tumor growth alone (C26) or in combination with chemotherapy [C26 oxaliplatin and 5-fluorouracil (oxfu)] and to evaluate the potential of moderate exercise. Oxfu administration to C26 mice exacerbated muscle wasting and triggered autophagy or mitophagy, decreased protein synthesis, and induced mitochondrial alterations. Exercise in C26 oxfu mice counteracted the loss of muscle mass and strength, partially rescuing autophagy and m…
Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Lo…
2019
Exercise and exercise-induced weight loss have a beneficial effect on overall health, including positive effects on molecular pathways associated with immune function, especially in overweight individuals. The main aim of our study was to assess how energy deprivation (i.e., "semi-starvation") leading to substantial fat mass loss affects the immune system and immunosuppression in previously normal weight individuals. Thus, to address this hypothesis, we applied a high-throughput systems biology approach to better characterize potential key pathways associated with immune system modulation during intensive weight loss and subsequent weight regain. We examined 42 healthy female physique athle…
Menstrual dysfunction and body weight dissatisfaction among Finnish young athletes and non-athletes.
2020
To determine the prevalence of menstrual dysfunction (MD; i.e. oligomenorrhea or amenorrhea) and attitudes towards body weight among athletes and non‐athletes, we studied a cohort of athletes and non‐athletes, in adolescence (14–16 years) and subsequently in young adulthood (18–20 years). We further studied the differences between athletes reporting MD and eumenorrheic athletes at both time periods and identified physical and behavioural characteristicsthat might predict MD in young adulthood. Data were collected using questionnaires, accelerometers, and a pre‐participation screening. In adolescence, the athletes reported current primary amenorrhea more often than the non‐athletes (4.7% vs.…
The Development and Initial Validation of a Short, Self-Report Measure on Social Inclusion for People with Intellectual Disabilities-A Transnational …
2021
Sport has been promoted as a means of increasing the social inclusion of persons with intellectual disabilities. Suitable tools for evaluating this claim are not readily available. The aim of this study was to develop a self-report tool for use by people with intellectual disabilities regarding the social inclusion they experience in sport and in the community. A three-phase process was used. In the first phase an item bank of questionnaire items was created and field-tested with 111 participants. Initial factor analysis identified 42 items which were further evaluated in Phase 2 with 941 participants from six European countries. Construct validity was established first through Exploratory …
Effects of a home-based rehabilitation program in community-dwelling older people after discharge from hospital: A subgroup analysis of a randomized …
2021
Objective: To examine whether pre-admission community mobility explains the effects of a rehabilitation program on physical performance and activity in older adults recently discharged from hospital. Design: A secondary analysis of a randomized controlled trial. Setting: Home and community. Participants: Community-dwelling adults aged ⩾60 years recovering from a lower limb or back injury, surgery or other disorder who were randomized to a rehabilitation ( n = 59) or standard care control ( n = 58) group. They were further classified into subgroups that were not planned a priori: (1) mild, (2) moderate, or (3) severe pre-admission restrictions in community mobility. Interventions: The 6-mont…
The Crisis of Free Movement in the European Union
2017
L’articolo argomenta che la costruzione istituzionale del processo di integrazione dell’Unione europea ha promosso la libera circolazione, producendo pero un effetto boomerang a causa delle dinamiche meccanicistiche che la caratterizzano. La reazione contro la liberta di movimento si manifesta nella riduzione dei diritti sociali riconosciuti ai cittadini , che a sua volta produce un incremento della precarieta dei migranti interni. Considerato l’elevato numero di cittadini UE mobili, limitare il loro accesso alla cittadinanza significa creare una vasta sottoclasse, poiche gli individui possono muoversi da un posto all’altro per lavorare, ma hanno un accesso differenziato ai diritti sociali …
‘Drawing’ conclusions : Irish primary school children’s understanding of physical education and physical activity opportunities outside of school
2017
This study explores the relationship between primary school physical education and physical activity as sites for the practice of physical activity of Irish primary school children. Understanding how children make connections between physical activity sites is important in shaping physical education experiences that promote lifelong participation. Children’s (aged 8–11) awareness, knowledge, and understanding of physical activity and physical education were examined using participatory methods of ‘draw and write’ ( n = 135) and focus group interviews ( n = 34). In Phase 1, data collection focused on physical activity, while Phase 2 focused on physical education and connections between phys…
Extracting locations from sport and exercise-related social media messages using a neural network-based bilingual toponym recognition model
2022
Funding: This study is a part of the “Equality in suburban physical activity environments, YLLI” research project (in Finnish: Yhdenvertainen liikunnallinen lähiö, YLLI). The project is being financed by the research program about suburban in Finland “Lähiöohjelma 2020-2022” coordinated by the Ministry of Environment (grant recipient: Dr. Petteri Muukkonen). Sport and exercise contribute to health and well-being in cities. While previous research has mainly focused on activities at specific locations such as sport facilities, “informal sport” that occur at arbitrary locations across the city have been largely neglected. Such activities are more challenging to observe, but this challenge may…
Ajatuksella ja ahkeruudella kolmen suvun vaiheista neljältä vuosisadalta
2018
Kirja-arvio teoksesta Immonen, Perttu: Suomen rahvaan historia. Kolmen suvun elämää keskiajalta 1800-luvulle. Atena Kustannus Oy, 2017. 639 sivua. ISBN 978- 952-300-335-4. Perttu Immonen yhdistää teoksessaan mielenkiintoisesti ja elävästi mikro- ja makrohistorian varhaismodernin ajan Suomessa. Hän seuraa kronologisesti kolmen eri seutukunnan: LänsiSuomen Sastamalan, Itä-Suomen Rantasalmen ja Pohjanmaan Kokkolan tapahtumia. Poikkeuksellisen ankarien aikojen kuvauksesta muodostuu moniulotteinen ja alueiden erilaisia kohtaloita tarkasteleva analyysi. nonPeerReviewed
Kokkeja, kajuuttavahteja ja oppilaita : miehistön nuorimmat jäsenet oululaisilla ja raahelaisilla purjealuksilla 1850 - 1860 -luvuilla
2012
Pro gradun tarkoituksena on selvittää oululaisten ja raahelaisten kauppa-alusten miehistön nuorimpien jäsenten merille lähtöä ja urakehitystä ensimmäisen viiden vuoden aikana. Työn tavoitteena on selvittää, minkä ikäisiä olivat nuoret merimiehet, millaiset sosiaaliset lähtökohdat heillä oli, miksi he pestautuivat, millaista elämä oli laivalla ja miten heidän uransa kehittyi jatkossa. Tarkastelu kohdistuu viiden vuoden jaksolle vuosina 1858-1863 ja mahdollisuuksien mukaan joidenkin miesten uraa on seurattu pidemmälti. Tutkimus edustaa kollektiivibiografista ja mikrohistoriallista tutkimusotetta. Tutkittavasta joukosta, 75 nuoresta miehestä, on luotu tietokantoja, joiden avulla selvitetään, m…