Search results for "kyy"
showing 10 items of 296 documents
Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism
2012
N-methyl-D-aspartate (NMDA) receptors belong to a family of ionotropic glutamate receptors that contribute to the signal transmission in the central nervous system. NMDA receptors are heterotetramers that usually consist of two GluN1 and GluN2 monomers. The extracellular ligand-binding domain (LBD) of a monomer is comprised of discontinuous segments that form the functional domains D1 and D2. While the binding of a full agonist glycine to LBD of GluN1 is linked to cleft closure and subsequent ion-channel opening, partial agonists are known to activate the receptor only sub-maximally. Although the crystal structures of the LBD of related GluA2 receptor explain the mechanism for the partial a…
Antipredatory function of head shape for vipers and their mimics.
2011
Most research into the adaptive significance of warning signals has focused on the colouration and patterns of prey animals. However, behaviour, odour and body shape can also have signal functions and thereby reduce predators' willingness to attack defended prey. European vipers all have a distinctive triangular head shape; and they are all venomous. Several non-venomous snakes, including the subfamily Natricinae, commonly flatten their heads (also known as head triangulation) when disturbed. The adaptive significance of this potential behavioural mimicry has never been investigated. We experimentally tested if the triangular head shape typical of vipers offers protection against predation.…
Robotizing meaningful work
2021
PurposeRobots have a history of replacing human labor in undesirable, dirty, dull and dangerous tasks. With robots now emerging in academic and human-centered work, this paper aims to investigate psychological implications of robotizing desirable and socially rewarding work.Design/methodology/approachTesting the holistic stress model, this study examines educational professionals’ stress responses as mediators between robotization expectations and future optimism in life. The study uses survey data on 2,434 education professionals.FindingsRespondents entertaining robotization expectations perceived their work to be less meaningful and reported more burnout symptoms than those with no roboti…
A Practical Perspective : The Effect of Ligand Conformers on the Negative Image-Based Screening
2019
Negative image-based (NIB) screening is a rigid molecular docking methodology that can also be employed in docking rescoring. During the NIB screening, a negative image is generated based on the target protein’s ligand-binding cavity by inverting its shape and electrostatics. The resulting NIB model is a drug-like entity or pseudo-ligand that is compared directly against ligand 3D conformers, as is done with a template compound in the ligand-based screening. This cavity-based rigid docking has been demonstrated to work with genuine drug targets in both benchmark testing and drug candidate/lead discovery. Firstly, the study explores in-depth the applicability of different ligand 3D conformer…
Ruumiinkokemusten eettisiä avauksia : myyttien uudelleenkirjoitukset Saila Susiluodon ja Sirpa Kyyrösen runoissa
2015
Tarkastelen pro gradu -tutkielmassani lähiluvun keinoin, millaisia naisruumiinkokemuksia Saila Susiluodon Siivekkäät ja Hännäkkäät (2001) ja Sirpa Kyyrösen Naispatsaita (2010)-runokokoelmista on luettavissa. Molemmissa teoksissa naisruumiinkokemuksia tuodaan esille myyttejä ja satuja uudelleenkirjoittamalla. Myyttien ja satujen uudelleenkirjoitukset puolestaan haastavat lukijan mukaan eettiseen dialogiin runoissa esitetyn ruumistematiikan kanssa tarjoamalla kulttuurisia mallikertomuksia epäileviä, kyseenalaistavia tai vastustavia lukija-asemia. Tutkielmani rakentuu johdantoluvusta, kirjallisuustieteellisestä artikkelista ja artikkelikäsikirjoituksen pohjalta laaditusta englanninkielisestä e…
Häpeäherkkyys, arvosuuntautuneisuus ja mahdolliset minät
2001
Observe while it happens : catching photoactive proteins in the act with non-adiabatic molecular dynamics simulations
2020
Organisms use photo-receptors to react to light. The first step is usually the absorption of a photon by a prosthetic group embedded inside the photo-receptor, often a conjugated chromophore. The electronic changes in the chromophore induced by photo-absorption can trigger a cascade of structural or chemical transformations that culminate into a response to light. Understanding how these proteins have evolved to mediate their activation process has remained challenging because the required time and spacial resolutions are notoriously difficult to achieve experimentally. Therefore, mechanistic insights into photoreceptor activation have been predominantly obtained with computer simulations. …
Plyometrisen harjoittelun vaikutukset hyppysuoritukseen ja harjoituksen aiheuttamiin fysiologisiin vasteisiin nuorilla ja ikääntyneillä naisilla
2014
Olli Leino (2014). Liikuntafysiologian Pro-gradutyö. Plyometrisen harjoittelun vaikutukset hyppysuoritukseen ja harjoittelun aiheuttamiin fysiologisiin vasteiisin nuorilla ja ikääntyneillä naisilla. Liikuntabiologian laitos, Jyväskylän yliopisto, 85 s. Ikääntyneiden ihmisten elämänlaatu on noussut tärkeäksi yhteiskunnalliseksi ja kansanterveydelliseksi tekijäksi kohonneen elinajanodotteen ja eläköitymisiän myötä. Merkittäviä ikääntymisen aiheuttamia biomekaanisia haittoja ovat koordinaation, voiman ja tasapainon heikkeneminen. Näistä syistä johtuvien kaatumistapaturmien hoito on yhteiskunnalle kallista ja ennaltaehkäisy siksi tärkeää. Alaraajojen plyometriaharjoittelun on todettu parantavan…
What Contributes to the Measured Chiral Optical Response of the Glutathione-Protected Au25 Nanocluster?
2023
The water-soluble glutathione-protected [Au25(GSH)18]−1 nanocluster was investigated by integrating several methodologies such as molecular dynamics simulations, essential dynamics analysis, and state-of-the-art time-dependent density functional theory calculations. Fundamental aspects such as conformational, weak interactions and solvent effects, especially hydrogen-bonds, were included and found to play a fundamental role in assessing the optical response of this system. Our analysis demonstrated not only that the electronic circular dichroism is extremely sensitive to the solvent presence but also that the solvent itself plays an active role in the optical activity of such system, formin…
Complexes of Glycolic Acid with Nitrogen Isolated in Argon Matrices. II : Vibrational Overtone Excitations
2019
Structural changes of glycolic acid (GA) complex with nitrogen induced by selective overtone excitation of the νOH mode were followed in argon matrices using FTIR spectroscopy. For the most stable SSC1 complex present in different trapping sites directly upon deposition site, selective changes in the νOH region were achieved upon near-infrared irradiation. Simultaneously, new conformers of the GA…N2 complex were formed, giving rise to several sets of bands in the νOH and νC=O regions of the spectra. Both position and intensity of new absorptions appeared to be highly sensitive on the wavelength of radiation used, as well as on the annealing of the matrix. Based on theoretical calculations a…