Search results for "laments"

Cytoskeletal Heterogeneity of an Epithelioid Sarcoma with Expression of Vimentin, Cytokeratins, and Neurofilaments

1990

We studied an unusual sarcoma with morphologic features diagnostic of epithelioid sarcoma by conventional light microscopy, transmission electron microscopy, and immunohistochemistry. The primary tumor, which was located in the deep soft tissues of the buttock of a 32-year-old woman, and its metastases to lymph nodes, liver, and lung were available for investigation. The histomorphological and ultrastructural appearance of the primary tumor and its metastatic deposits were typical of epithelioid sarcoma. Immunohistochemistry revealed a strong and uniform reactivity for vimentin in both the primary tumor and its metastases. In contrast, a marked cytoskeletal heterogeneity became evident for …

Anti-vimentin staining in muscle pathology

1993

The intermediate filaments of immature muscle fibres contain desmin and vimentin; vimentin is lacking in mature fibres. Regenerating fibres react with anti-vimentin antibodies and more intensely for desmin than mature fibres. The aim of the present study was to evaluate anti-vimentin staining for muscle pathology. Anti-vimentin-reactive fibres were found in 40 of 89 biopsies assessed. Fifteen patients with progressive destructive myopathy, infantile spinal muscular atrophy, clinically suspected Leigh's disease or unclassifiable congenital myopathy had between 1% and 95% vimentin-positive fibres. Less than 1% positive fibres were found in 25 patients with neuropathy with secondary myopathy o…

Response by Uphaus et al to Letter Regarding Article, “NfL (Neurofilament Light Chain) Levels as a Predictive Marker for Long-Term Outcome After Isch…

2019

Polyelectrolyte properties of filamentous biopolymers and their consequences in biological fluids.

2014

Anionic polyelectrolyte filaments are common in biological cells. DNA, RNA, the cytoskeletal filaments F-actin, microtubules, and intermediate filaments, and polysaccharides such as hyaluronan that form the pericellular matrix all have large net negative charge densities distributed over their surfaces. Several filamentous viruses with diameters and stiffnesses similar to those of cytoskeletal polymers also have similar negative charge densities. Extracellular protein filaments such collagen, fibrin and elastin, in contrast, have notably smaller charge densities and do not behave as highly charged polyelectrolytes in solution. This review summarizes data that demonstrate generic counterion-…

Structural and regulatory functions of keratins.

2007

The diversity of epithelial functions is reflected by the expression of distinct keratin pairs that are responsible to protect epithelial cells against mechanical stress and to act as signaling platforms. The keratin cytoskeleton integrates these functions by forming a supracellular scaffold that connects at desmosomal cell-cell adhesions. Multiple human diseases and murine knockouts in which the integrity of this system is destroyed testify to its importance as a mechanical stabilizer in certain epithelia. Yet, surprisingly little is known about the precise mechanisms responsible for assembly and disease pathology. In addition to these structural aspects of keratin function, experimental e…

Permanent plastid — nuclear complexes (PNCs) in plant cells

2008

Conventional opinion assumes random distribution of plastids in the plant cell and light regulated movement realised with a help of stromules and actin microfilaments. In several organisms from protists to plants the joining of chloroplasts to the nucleus has been mentioned as a phenomenon [1–3]. However, little is known what plants and tissues and how frequently contain these structures? Whether appearance of PNC in cell depends on the state of differentiation? What is physiologic role of the PNC.

Reglamento de la M. I. Cofradía y Hermandad de Jesús Nazareno y Santísima Cruz : establecida en la Iglesia de Ntra. Sra. del Pilar de esta ciudad.…

1889

Reglamento de la Junta de Fábrica de la Real y Parroquial Iglesia de Los Santos Juanes Bautista y Evangelista de esta ciudad de Valencia : aprobado …

Sociālo mediju izmantošana Eiropas pilsonības izpratnes veidošanā jauniešu auditorijas vidū Latvijā.

2016

Darbā ir pētīts potenciāls ES institūcijām izmantot sociālos medijus komunikācijā ar iedzīvotājiem. Tai skaitā, lai veidotu iedzīvotāju, un jo īpaši jauniešu, Eiropas pilsonības izpratni. Teorētiskajā daļā apkopotajos materiālos Eiropas pilsonība ir analizēta no trīs aspektiem: piederības, tiesībām un līdzdalības. Maģistra darbā ir apkopoti pastāvošie uzskati par sociālo mediju izmantošanu institūciju saziņā ar iedzīvotājiem un pamatojums šādas saziņas nepieciešamībai. Empīriskajā daļā ir analizēts Eiropas Parlamenta latviešu valodā esošajos četros sociālo mediju kontos publicētais saturs par laika periodu no 2015. gada 1. jūlija līdz 31. decembrim. Pētījuma rezultāti sniedz uzskatāmu priek…

Small heat shock proteins and the cytoskeleton: an essential interplay for cell integrity?

2012

Abstract The cytoskeleton is a highly complex network of three major intracellular filaments, microfilaments (MFs), microtubules (MTs) and intermediate filaments (IFs). This network plays a key role in the control of cell shape, division, functions and interactions in animal organs and tissues. Dysregulation of the network can contribute to numerous human diseases. Although small HSPs (sHSPs) and in particular HSP27 (HSPB1) or αB-crystallin (HSPB5) display a wide range of cellular properties, they are mostly known for their ability to protect cells under stress conditions. Mutations in some sHSPs have been found to affect their ability to interact with cytoskeleton proteins, leading to IF a…