Search results for "laments"
showing 10 items of 68 documents
Submicrometer-Sized Roughness Suppresses Bacteria Adhesion.
2020
Biofilm formation is most commonly combatted with antibiotics or biocides. However, proven toxicity and increasing resistance of bacteria increase the need for alternative strategies to prevent adhesion of bacteria to surfaces. Chemical modification of the surfaces by tethering of functional polymer brushes or films provides a route toward antifouling coatings. Furthermore, nanorough or superhydrophobic surfaces can delay biofilm formation. Here we show that submicrometer-sized roughness can outweigh surface chemistry by testing the adhesion of E. coli to surfaces of different topography and wettability over long exposure times (>7 days). Gram-negative and positive bacterial strains are tes…
Patterns of Expression and Organization of Cytokeratin Intermediate Filaments
1985
Cytokeratins are a large multigene family comprising two polypeptide types, i.e. acidic (type I) and basic (type II) ones, which are distinguished on the basis of immunological, peptide mapping, mRNA hybridization, and primary amino acid sequence data. The acidic (type I) cytokeratins can be subdivided into at least two different subtypes on the basis of their carboxy-terminal sequences. Considerable interspecies conservation of sequences exists, even extending to the 3'-non-coding mRNA regions. Different pairs of type I and II cytokeratins show different resistance to dissociation in urea. Sequence differences of the type I cytokeratins containing functional domains may be an explanation o…
Tension Causes Unfolding of Intracellular Vimentin Intermediate Filaments
2020
Intermediate filament (IF) proteins are a class of proteins that constitute different filamentous structures in mammalian cells. As such, IF proteins are part of the load-bearing cytoskeleton and support the nuclear envelope. Molecular dynamics simulations show that IF proteins undergo secondary structural changes to compensate mechanical loads, which is confirmed by experimental in vitro studies on IF hydrogels. However, the structural response of intracellular IF to mechanical load is yet to be elucidated in cellulo. Here, in situ nonlinear Raman imaging combined with multivariate data analysis is used to quantify the intracellular secondary structure of the IF cytoskeletal protein viment…
Baltijas valstu deputātu ietekmes modelis Eiropas Parlamentā
2019
Deputātu ietekme parlamentārajā darbā tiek pētīta salīdzinoši nesen. Šobrīd ir pieejami tikai divi modeļi ar kuriem ir iespējams noteikt deputātu ietekmi Eiropas Parlamentā, bet neviens no tiem nav mēģinājis skaidrot, kāpēc deputāts ir ietekmīgs un kuri faktori ir par to ir atbildīgi. Balstoties uz teorētisko literatūru, kurā tiek pētīti dažādi Eiropas Parlamenta deputātu fona faktori, tiek prognozēts ietekmīga deputāta profils. Šī darba tēma ir “Baltijas valstu deputātu ietekmes modelis Eiropas Parlamentā”. Tās uzdevums ir izveidot jaunu ietekmes noteikšanas modeli, kurš spēj noteikt un prognozēt deputāta ietekmi pirms nonākšanas Eiropas Parlamentā. Viens no darba galvenajiem mērķiem ir sa…
Neurofilament light chain levels reflect outcome in a patient with glutamic acid decarboxylase 65 antibody–positive autoimmune encephalitis under imm…
2020
Neurological immune-mediated side effects are rare but often severe complications of immune checkpoint inhibitor (ICI) treatment. This report describes a severe case of nivolumab/ipilimumab-associated glutamic acid decarboxylase 65-positive autoimmune encephalitis. It proposes neurofilament light chain levels, a biomarker indicating axonal damage, in the cerebrospinal fluid and serum as a putative novel biomarker for this diagnostically and therapeutically challenging entity with an often unfavorable outcome. Additionally, we provide an overview of previous reports of patients developing autoimmune encephalitis under ICI treatment.
Reglamento de la Obrería Mayor de la Real y Parroquial Iglesia de los Santos Juanes Bautista y Evangelista de esta ciudad
1890
The potential of serum neurofilament as biomarker for multiple sclerosis
2021
Abstract Multiple sclerosis is a highly heterogeneous disease, and the detection of neuroaxonal damage as well as its quantification is a critical step for patients. Blood-based serum neurofilament light chain (sNfL) is currently under close investigation as an easily accessible biomarker of prognosis and treatment response in patients with multiple sclerosis. There is abundant evidence that sNfL levels reflect ongoing inflammatory-driven neuroaxonal damage (e.g. relapses or MRI disease activity) and that sNfL levels predict disease activity over the next few years. In contrast, the association of sNfL with long-term clinical outcomes or its ability to reflect slow, diffuse neurodegenerativ…
Likumu pieņemšana steidzamības kārtā un to ietekmējošie faktori. 9. un 11. Saeimas gadījumu analīze
2016
Darba tēma ir saistīta ar likumu pieņemšanu steidzamības kārtā un to nosakošajiem faktoriem. Pētījuma pamatā ir problēmjautājums, kā politiskie aktieri ietekmē likumprojektu pieņemšanu steidzamības kārtā, un vai steidzamības kārta ietekmē likuma kvalitāti. Līdz ar to var tikt ietekmēta valsts politika. Darba mērķi ir noskaidrot, kas nosaka likumprojektu pieņemšanu steidzamības kārtā, kas ir to iesniedzēji, un kuras komisijas atbildīgas. Darbā noteikti uzdevumi ir uzzināt faktorus, kas nosaka likumu pieņemšanu steidzamības kārtā, un kuri nozīmīgākie politiskie aktieri. Darbā tiek izmantota gadījuma analīze. Analīzes rezultātā tika noskaidrots, ka politiskie aktieri, kas ir komisijas, spēj ie…
Ultrastructure of one Ewing's sarcoma of bone with endothelial character and a comparative review of the vessels in 27 cases of typical Ewing's sarco…
1980
An atypical variant of Ewing's sarcoma, located in the left hip of a nine-year-old girl, is discussed at optical, histochemical and electron microscopical level. The endothelial appearing cells seem to play a main role in its histogenesis. Tumoral cells of an undifferentiated blastemic nature show round nuclei and bright lucent cytoplasm, being organized in solid sheets or vascular-like profiles. Alkaline and acid phosphatases are very prominent in all tumoral cells, and some of them also show PAS positive material. Its ultrastructure demonstrates an active pinocytic capacity, cytoplasmic filaments and Weibel-Palade bodies. Simultaneously a review is performed on 27 cases of typical Ewing's…
Cytokeratin 8 immunostaining pattern and E-cadherin expression distinguish lobular from ductal breast carcinoma.
2000
Immunohistochemistry using antibodies to cytokeratin 8 can serve as a valuable diagnostic tool for the differentiation of lobular from ductal carcinomas of the breast. In contrast with ductal carcinomas, which exhibit a peripheral-predominant immunostaining pattern, adjacent tumor cells “molding” to each other, lobular carcinomas exhibit a ring-like perinuclear immunostaining pattern, creating a “bag of marbles” appearance with neighboring tumor cells. This immunostaining pattern is stable even in the tumors that otherwise do not exhibit characteristic histomorphologic features (ie, solid or pleomorphic type of a lobular carcinoma) and tumors that mimic growth patterns characteristic of the…