Search results for "levan"
showing 10 items of 672 documents
Human Systems Design: Towards an Integrative Conceptual Framework
2020
International audience; Conceiving artefacts and tools is one of the major key characteristics of the human species. Since the beginning of automation and even more since the spreading of computer science, this activity has become more and more challenging especially through the analysis of the different interaction modes between the artifacts and the human. Nowadays, developing an artifact that must interact with a human is requiring an integrative point of view which must include biological, physical and cybernetical concerns. The current norms aimed at characterizing the quality and the relevance of human machine interface are generally limited to standard interfaces and/or to specific d…
Adjusted bat algorithm for tuning of support vector machine parameters
2016
Support vector machines are powerful and often used technique of supervised learning applied to classification. Quality of the constructed classifier can be improved by appropriate selection of the learning parameters. These parameters are often tuned using grid search with relatively large step. This optimization process can be done computationally more efficiently and more precisely using stochastic search metaheuristics. In this paper we propose adjusted bat algorithm for support vector machines parameter optimization and show that compared to the grid search it leads to a better classifier. We tested our approach on standard set of benchmark data sets from UCI machine learning repositor…
Applying System Dynamics Modelling to Strategic Management: A Literature Review
2016
System dynamics (SD) has been proved to be a useful methodology to support both understanding and learning processes of complex systems and phenomena. Since its origin, SD has been successfully applied to many different fields of studies (e.g. climate change, physics, engineering, environmental sciences, economics, management, etc.). Among these, strategic management (SM) has a particular relevance as testified by several streams of research that originate from the combination between SD modelling and SM. The aim of this paper is to explore and discuss the theoretical and empirical development of SD in the SM field through a systematic analysis of the literature in order to highlight the ma…
Adolescents’ food packaging perceptions. Does gender matter when weight control and health motivations are considered?
2016
Abstract This paper investigates, first, to what extent adolescents highly involved in food are more worried about weight control and health than less involved adolescents. Second, it studies the impact of both food choice motivations on food packaging relevance, considering both, visual and informative packaging cues. Finally, these relationships are re-tested in two different frameworks: men and to this end, 589 adolescent consumers between 14 and 17 years were questioned. The interviews were done personally by an external company at the door of 30 different schools. Our results have confirmed the relevance of packaging informative cues over visual cues for adolescents highly worried abou…
Phosphorylation of CENP-A on serine 7 does not control centromere function.
2019
CENP-A is the histone H3 variant necessary to specify the location of all eukaryotic centromeres via its CENP-A targeting domain and either one of its terminal regions. In humans, several post-translational modifications occur on CENP-A, but their role in centromere function remains controversial. One of these modifications of CENP-A, phosphorylation on serine 7, has been proposed to control centromere assembly and function. Here, using gene targeting at both endogenous CENP-A alleles and gene replacement in human cells, we demonstrate that a CENP-A variant that cannot be phosphorylated at serine 7 maintains correct CENP-C recruitment, faithful chromosome segregation and long-term cell viab…
EvalMSA: A Program to Evaluate Multiple Sequence Alignments and Detect Outliers
2016
8 páginas, 3 figuras, 2 tablas.
CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly
2016
SummaryHuman centromeres are defined by chromatin containing the histone H3 variant CENP-A assembled onto repetitive alphoid DNA sequences. By inducing rapid, complete degradation of endogenous CENP-A, we now demonstrate that once the first steps of centromere assembly have been completed in G1/S, continued CENP-A binding is not required for maintaining kinetochore attachment to centromeres or for centromere function in the next mitosis. Degradation of CENP-A prior to kinetochore assembly is found to block deposition of CENP-C and CENP-N, but not CENP-T, thereby producing defective kinetochores and failure of chromosome segregation. Without the continuing presence of CENP-A, CENP-B binding …
DEBATE: Do interventions based on behavioral theory work in the real world?
2019
Abstract Background Behavioral scientists suggest that for behavior change interventions to work effectively, and deliver population-level health outcomes, they must be underpinned by behavioral theory. However, despite implementation of such interventions, population levels of both health outcomes and linked behaviors have remained relatively static. We debate the extent to which interventions based on behavioral theory work in the real world to address population health outcomes. Discussion Hagger argues there is substantive evidence supporting the efficacy and effectiveness of interventions based on behavioral theory in promoting population-level health behavior change in the ‘real world…
The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.
2019
The adhesion class of G protein-coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell-cell adhesion, while the CTFs are involved in classical G protein signaling, as well…
Designing food packaging for the Spanish market: Do motivations differ between involved and non-involved adolescents?
2018
Abstract This paper investigates the relationships among food choice motivations and the relevance of packaging elements (visual and informative elements) in the adolescent market. In addition, these relationships are re-tested in two different frameworks: high-involved consumers and low-involved consumers. 590 young consumers between 13 and 17 years were interviewed at the door of their public or private schools. Structural Modelling was used to test our hypotheses. The first analysis was done considering the global sample. The second one split off the sample into two groups: 351 high-involved adolescents and 239 low-involved adolescents. Our results showed, on one side, that weight contro…