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RESEARCH PRODUCT
The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.
Simone PrömelSwati SrivastavaNariman BalengaDemet AraçHee Yong KimNicole ScholzUwe WolfrumYuri A. UshkaryovRory K. MorganRandy A. HallMario VallonJames P. BridgesJames P. BridgesDeva Krupakar KusuluriGabriela AustBenoit VanhollebekeRyan S. GrayAntony A. BoucardXianhua PiaoKelly R. MonkKatherine LeonAmit MoghaErwin G. Van MeirMaike D. GlitschCheng-chih HsiaoKevin M. WrightInes LiebscherGarret R. AndersonAlexander Bernd KnierimCaroline J. FormstoneCaroline J. FormstoneFelix B. EngelKimberley F. ToliasDoreen Thorsubject
0301 basic medicineG proteinGeneral Science & TechnologyArticleGeneral Biochemistry Genetics and Molecular BiologyReceptors G-Protein-Coupledimmunology03 medical and health sciencesG-Protein-Coupled0302 clinical medicineHistory and Philosophy of ScienceReceptorsExtracellularAnimalsHumanscancerstructural biologymechanosensationReceptordevelopmentG protein-coupled receptorChemistryGeneral NeuroscienceneurobiologySciences bio-médicales et agricolesTransmembrane proteinCell biology030104 developmental biologyStructural biologyGeneric health relevanceSignal transductionadhesion G protein-coupled receptor030217 neurology & neurosurgeryIntracellularsignal transductionSignal Transductiondescription
The adhesion class of G protein-coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell-cell adhesion, while the CTFs are involved in classical G protein signaling, as well as other intracellular signaling. In this workshop report, we review the most recent findings on the biology, signaling mechanisms, and physiological functions of aGPCRs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-06-06 |