Search results for "ley"
showing 10 items of 1218 documents
Neural oscillations in the infralimbic cortex after electrical stimulation of the amygdala. Relevance to acute stress processing
2017
The stress system coordinates the adaptive reactions of the organism to stressors. Therefore, dysfunctions in this circuit may correlate to anxiety-related disorders, including depression. Comprehending the dynamics of this network may lead to a better understanding of the mechanisms that underlie these diseases. The central nucleus of the amygdala (CeA) activates the hypothalamic–pituitary–adrenal axis and brainstem nodes by triggering endocrine, autonomic and behavioral stress responses. The medial prefrontal cortex plays a significant role in regulating reactions to stressors, and is specifically important for limiting fear responses. Brain oscillations reflect neural systems activity. S…
Toward evidence-based severity assessment in rat models with repeated seizures: I. Electrical kindling
2018
Objective: Rodent epilepsy models can significantly contribute to our understanding of pathophysiological mechanisms and to validation of biomarker and target candidates. Evidence-based severity assessment is a presupposition for the ethical evaluation of animal experimentation allowances as well as for the development of efficacious refinement concepts. Methods: Aiming to improve our understanding of the impact of experimental procedures and repeated seizures, we have completed a comprehensive behavioral and biochemical analysis assessing various parameters that can inform about the influence of an electrical kindling paradigm on well-being in rats. Thereby, we have focused on the immediat…
Toward evidence-based severity assessment in rat models with repeated seizures: III. Electrical post-status epilepticus model
2019
Objective Ethical approval of experiments in chronic epilepsy models requires a careful balancing of the expected gain-in-knowledge with the level of distress. Thus recommendations for evidence-based severity assessment and classification are urgently needed for preclinical epilepsy research. Methods Therefore, we have completed a comprehensive analysis of alterations in behavioral, biochemical, and physiological parameters in a rat electrical post-status epilepticus model. Selected parameters were repeatedly analyzed during different experimental phases to obtain information about the level of distress throughout the course of the model. Results Behavioral patterns comprised an increase in…
Seeding nerve sutures with minced nerve-graft (MINE-G): a simple method to improve nerve regeneration in rats
2017
Background: The aim of this study was to assess the effect of seeding the distal nerve suture with nerve fragments in rats. Methods: On 20 rats, a 15 mm sciatic nerve defect was reconstructed with a nerve autograft. In the Study Group (10 rats), a minced 1 mm nerve segment was seeded around the nerve suture. In the Control Group (10 rats), a nerve graft alone was used. At 4 and 12 weeks, a walking track analysis with open field test (WTA), hystomorphometry (number of myelinated fibers (n), fiber density (FD) and fiber area (FA) and soleus and gastrocnemius muscle weight ratios (MWR) were evaluated. The Student t-test was used for statistical analysis. Results: At 4 and 12 weeks the Study Gr…
Ca2+ signalling plays a role in celastrol‐mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in…
2019
Background and purpose Celastrol exhibits anti-arthritic effects in rheumatoid arthritis (RA), but the role of celastrol-mediated Ca2+ mobilization in treatment of RA remains undefined. Here, we describe a regulatory role for celastrol-induced Ca2+ signalling in synovial fibroblasts of RA patients and adjuvant-induced arthritis (AIA) in rats. Experimental approach We used computational docking, Ca2+ dynamics and functional assays to study the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase pump (SERCA). In rheumatoid arthritis synovial fibroblasts (RASFs)/rheumatoid arthritis fibroblast-like synoviocytes (RAFLS), mechanisms of Ca2+ -mediated autophagy were analysed by histological, immunohis…
Anthropometric characteristics and vertical jump abilities by player position and performance level of junior female volleyball players
2021
Although absolute jump heights should be considered an important factor in judging the performance requirements of volleyball players, limited data is available on age-appropriate categories. The purpose of this study is to determine the differences in specific anthropometric characteristics and jumping performance variables in under−19 female volleyball players in relation to playing position and performance level. The sample of subjects consisted of 354 players who prepared for the U19 Women’s Volleyball European Championship 2020 (17.4 ± 0.8 years, 1.81 ± 0.07 m, 67.5 ± 7.1 kg). Playing positions analyzed were setters (n = 55), opposites (n = 37), middle blockers (n = 82), outside hitter…
Why reg. (eu) no. 1103/2016 and 1104/2016 impact on the european citizens daily life?
2021
Why families do need the tools and instruments implemented by PSEFS Project? Why this is not an issue for lawyers, judges and University professors only. The answer to this question is that Reg. (EU) no. 1103/2016 and no. 1104/2016 impact on the European citizens daily life. We follow the problems of a young couple in order to have a better understanding and an evidence of this statement.
1983-1985 Primeras leyes de la Generalitat Valenciana: La Ley del Gobierno Valenciano. Ley de coordinación de las Diputaciones. Proyecto de Ley de co…
2014
La creación de la Generalitat Valenciana, como institución de nueva creación en base a la Constitución de 1978 y la aprobación del Estatuto de autonomía de la CV de 1 de julio de 1982, tendría que desarrollar la legislación derivada de las competencias estatutarias. En este capítulo nos referimos a tres leyes: La Ley del Gobierno Valenciano y el Reglamento de la Conselleria de la Presidencia; Ley de coordinación de las Diputaciones y el recurso de la ley de coordinación de diputaciones en el Tribunal Constitucional, su aprobación y como el Consell fija las Directrices de Coordinación de las Diputaciones. Por último, la Ley de comarcalización. La Generalitat tendrá que legislar y reglamentar…
1984. La agenda legislativa de la Generalitat en la Iª legislatura. Leyes de símbolos de la Comunidad Valenciana y de creación de Radiotelevisión Val…
2014
La creación de la nueva Generalitat Valenciana tendría una agenda apretada en su primera legislatura. Tras las elecciones y la constitución del Consell, la prioridad seria negociar las transferencias y presupuestos del Estado a la Generalitat, y la de aprobar toda una serie de leyes derivadas de las competencias estatutarias. Se partía de cero. La Generalitat era una institución nueva, con parlamento propio, que tenía que sentar las bases legales de toda una nueva estructura administrativa y funcionarial. En definitiva, la primera legislatura iba a centrarse en la construcción del entramado jurídico de la recién creada Generalitat. En este capitulo recogemos la Ley de símbolos de la Comunid…
La economia social en la Comunitat Valenciana: regulación y políticas públicas
2019
El reconocimiento y fomento de la economía social es una tarea de interés general que deben desarrollar los poderes públicos, como ordena la Ley 5/2011 de Economía Social, lo que impele también a la Generalitat Valenciana. El libro que el lector tiene en sus manos se compone de tres partes. En la primera se analiza la experiencia de otras Comunidades Autónomas que han realizado en los últimos años avances en la materia, tanto en la regulación de la economía social como en la activación de políticas de apoyo a la economía social. Estas experiencias constituyen un referente para la realidad de la Comunitat Valenciana, Comunidad que, si bien en 2006 modi- có su Estatuto de Autonomía para asumi…