Search results for "lh"

The Death of the Subject in David Lynch's Lost Highway and Mulholland Drive

2003

International audience; Quel est le sujet de ces deux films qui ont suscité de nombreuses interrogations auprès du public lors de leur sortie, questions portant notamment sur la signification de la diégèse ? Nous avançons que ce n'est pas à ce niveau-là que l'on doit chercher le sens des films de Lynch. En fait, la mort du personnage comme sujet va de pair avec l'absence d'une histoire ; l'évolution du cinéma de Lynch montre que, si sujet il y a, c'est du côté du spectateur qui tient désormais le rôle de l'enquêteur que tenait les personnages dans les œuvres antérieures (Blue Velvet et la série Twin Peaks). Le sujet lynchien apparaît alors un véritable objet dans une composition qui se refl…

Wilhelm Pantenius, Jelgawas latweeschu draudzes rihta mahzitajs: us Jelgawas pilsehta un lauku draudses luhgschanu [Vilhelms Panteniuss, Jelgavas lat…

1850

A pollen test to detect ACCase target-site resistance within Alopecurus myosuroides populations

2000

International audience

Macromolecular Prodrugs Based on Synthetic Polyaminoacids: Drug Delivery and Drug Targeting in Antitumor Therapy

2011

In the last twenty years a depth study on potential pharmaceutical applications of synthetic polymers at proteinlike structure as carrier for macromolecular prodrug production has been performed in academia and in industry. In particular α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA), α,β-polyaspartylhydrazide (PAHy), poly(glutamic acid) (PGA), poly(aspartic acid) (PAA) and polylysine (PLL) have been extensively studied in this field. In the present review, the use of PHEA, PAHy, PGA as starting materials to prepare macromolecular prodrugs is reported and drug delivery and targeting aspects have been considered.

NEW SELF-ASSEMBLING POLYASPARTYLHYDRAZIDE COPOLYMER MICELLES FOR ANTICANCER DRUG DELIVERY.

2010

A new amphiphilic copolymer have been synthesized starting from the hydrosoluble polyaspartylhydrazide (PAHy) polymer, by grafting both hydrophilic PEG(2000) chains and hydrophobic palmitic acid (C(16)) moieties on polymer backbone, and the structure of obtained PAHy-PEG(2000)-C(16) copolymer have been characterized by 2D (1)H/(13)C NMR experiments. PAHy-PEG(2000)-C(16) copolymer showed the ability of self-assembling in aqueous media giving a core-shell structure and resulted potentially useful for encapsulating and dissolving hydrophobic drug. The formation of micellar core-shell structure has been investigated by 2D (1)H NMR NOESY experiments. The presence of cross-peaks for protons of C(…

Repeated evolution of soldier sub-castes suggests parasitism drives social complexity in stingless bees

2016

The differentiation of workers into morphological castes represents an important evolutionary innovation that is thought to improve division of labor in insect societies. Given the potential benefits of task-related worker differentiation, it is puzzling that physical worker castes, such as soldiers, are extremely rare in social bees and absent in wasps. Following the recent discovery of soldiers in a stingless bee, we studied the occurrence of worker differentiation in 28 stingless bee species from Brazil and found that several species have specialized soldiers for colony defence. Our results reveal that worker differentiation evolved repeatedly during the last ~ 25 million years and coinc…

Simultaneous pituitary–gonadal recrudescence in two Corsican populations of male blue tits with asynchronous breeding dates

2006

Animal populations living in geographically variable environments respond to different selection pressures. The adaptive character of the responses to environmental information determines the degree of synchrony of the breeding period with local optimal conditions. An example is provided by two populations of Mediterranean blue tits (Parus caeruleus) in Corsica, breeding in different habitats, with a 1-month difference in the onset of egg laying. This difference in the onset of lay is supposed to be adaptive because, although chicks from both populations are raised mostly on caterpillars, the timing of the appearance of caterpillars is earlier for populations of tits associated with deciduo…

Small Bowel Carcinomas in Coeliac or Crohn’s Disease: Clinico-pathological, Molecular, and Prognostic Features. A Study From the Small Bowel Cancer I…

2017

Background and aims An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's disease [CrD]. We explored clinico-pathological, molecular, and prognostic features of CD-associated SBC [CD-SBC] and CrD-associated SBC [CrD-SBC] in comparison with sporadic SBC [spo-SBC]. Methods A total of 76 patients undergoing surgical resection for non-familial SBC [26 CD-SBC, 25 CrD-SBC, 25 spo-SBC] were retrospectively enrolled to investigate patients' survival and histological and molecular features including microsatellite instability [MSI] and KRAS/NRAS, BRAF, PIK3CA, TP53, HER2 gene alterations. Results CD-SBC showed a significantly better sex-, age-, and st…

Therapeutic Perspectives in Psychoneuroendocrinimmunology(PNEI): Potential Role of Phosphatidylserine in Neuroendocrine-Immune Communications

1990

(1990). Therapeutic Perspectives in Psychoneuroendocrinimmunology(PNEI): Potential Role of Phosphatidylserine in Neuroendocrine-Immune Communications. International Journal of Neuroscience: Vol. 51, No. 3-4, pp. 299-301.

Histamine inhibits 5-hydroxytryptamine release from the porcine small intestine: Involvement of H3 receptors

1992

Abstract Strips of the porcine small intestine were incubated in vitro, and the release of 5-hydroxytryptamine (5-HT) was determined by high-pressure liquid chromatography with electrochemical detection. Removal of the mucosa resulted in a large reduction (95%) of tissue 5-HT, suggesting that enterochromaffin cells are the main source of 5-HT. The release of 5-HT was reduced by 70% after omission of calcium. Tetrodotoxin and hexamethonium reduced the release of 5-HT by 30%–40% in a nonadditive manner, indicating a spontaneous neuronal (nicotinic) excitatory input to the enterochromaffin cells. Histamine inhibited the release of 5-HT by about 50%. This effect was not affected by mepyramine o…