Search results for "libraries"

showing 10 items of 255 documents

A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Tre…

2020

Abstract Despite huge progress in hormonal therapy and improved in vitro fertilization methods, the success rates in infertility treatment are still limited. A recently discovered mechanism revealed the interplay between the plasma protein fetuin‐B and the cortical granule‐based proteinase ovastacin to be a novel key mechanism in the regulation of fertilization. Upon sperm–egg fusion, cleavage of a distinct zona pellucida component by ovastacin destroys the sperm receptor, enhances zona robustness, and eventually provides a definitive block against polyspermy. An untimely onset of this zona hardening prior to fertilization would consequently result in infertility. Physiologically, this proc…

Models Molecularmedicine.medical_treatmentHydroxamic Acids01 natural sciencesBiochemistryMiceHuman fertilizationIn vitro fertilizationDrug DiscoveryGeneral Pharmacology Toxicology and PharmaceuticsAminesZona pellucidametzincinseducation.field_of_studyMolecular StructureCommunicationFemale infertilitySperm receptorPolyspermyCell biologymedicine.anatomical_structureastacinsHydroxamateMolecular MedicineFemalemetalloproteinaseinfertilityInfertility FemaleInfertilityendocrine systemCortical granuleBiologySmall Molecule LibrariesStructure-Activity RelationshipmedicineAnimalseducationPharmacologyIn vitro fertilisationDose-Response Relationship Drugurogenital system010405 organic chemistryOrganic Chemistryin vitro fertilizationmedicine.diseaseovastacinCommunications0104 chemical sciences010404 medicinal & biomolecular chemistryBiocatalysisMetalloproteasesChemMedChem
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Metadata-Oriented Language Model in Translingual Retrieval of Digital Data

2015

Translingual retrieval relies on processing a source language to retrieve digital document content in a target language. From the perspective of successful browsing digital catalogues, probability of retrieving the full text document in a language other than the query language is close to zero owning to the fact that it is not only the library collection, but especially a problem of matching the index terms with the query keywords which are assumed to be their translation equivalents. In addition, hardly any digital library system is incorporated with a translation component. As a result, such a matching is rather coincidental. Our approach to the translingual document retrieval problem is …

Multilingual Digital LibrariesInformation retrievalComputer sciencebusiness.industryInformationSystems_INFORMATIONSTORAGEANDRETRIEVALLanguage Modellingcomputer.software_genreQuery languageCross-Language Information RetrievalQuery expansionUniversal Networking LanguageComputingMethodologies_DOCUMENTANDTEXTPROCESSINGData control languageLanguage modelArtificial intelligenceDocument retrievalbusinesscomputerNatural language processingCross-language information retrievalRDF query languagecomputer.programming_language
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Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis

2006

10 pages, 5 figures.-- PMID: 16341125 [PubMed].-- Available online Dec 9, 2005.

Multiprotein complexCytochromeProtein-protein interactionsApoptosisCaspase 3MitochondrionLigandsCell LineChemical librarychemistry.chemical_compoundPeptide LibraryApoptosomesPeptoidHumansCombinatorial libraries inhibitorApoptosomeProtein PrecursorsMolecular BiologybiologyCaspase 3Intrinsic apoptosisCytochromes cCell BiologyCaspase InhibitorsCaspase 9Recombinant ProteinsMitochondriaCell biologyEnzyme ActivationCaspasa-9Apoptotic Protease-Activating Factor 1chemistryBiochemistryN-substituted GlycinesApoptosisCaspasa-3biology.proteinApoptosomeApaf-1Molecular recognitionSmall moleculeProtein BindingCell Death & Differentiation
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Dynamics of ionized and neutral gas in M8

2017

We present a spectroscopic study of the dynamics of the ionized and neutral gas throughout the Lagoon nebula (M8), using VLT/FLAMES data from the Gaia-ESO Survey. We explore the connections between the nebular gas and the stellar population of the associated star cluster NGC6530. We characterize through spectral fitting emission lines of H{alpha}, [NII] and [SII] doublets, [OIII], and absorption lines of sodium D doublet, using data from the FLAMES/Giraffe and UVES spectrographs, on more than 1000 sightlines towards the entire face of the Lagoon nebula. Gas temperatures are derived from line-width comparisons, densities from the [SII] doublet ratio, and ionization parameter from H{alpha}/[N…

NebulaeAstrophysics and AstronomyInterstellar mediumPhysicsH II regionsAstrophysics::Instrumentation and Methods for AstrophysicsAstrophysics::Solar and Stellar AstrophysicsAstrophysics::Earth and Planetary AstrophysicsAstrophysics::Cosmology and Extragalactic AstrophysicsNatural SciencesComputer Science::Digital LibrariesAstrophysics::Galaxy Astrophysics
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Leading order corrections to the Bethe-Heitler process in the γp→l+l−p reaction

2019

The ratio of dilepton production cross sections on a proton, using the γp→l+l−p process, above and below the dimuon production threshold allows one to extract the effective lepton-proton interaction, which is required to be identical for electrons and muons if lepton universality is exact. To test for a scenario of broken universality at the percent level, of the size that could explain the different proton charge radii extracted from electron scattering and from muonic hydrogen spectroscopy, we evaluate all one-loop QED corrections to this process, including the full lepton mass dependencies. We furthermore show that two photon–exchange processes with both photons attached to the proton li…

Nuclear ExperimentComputer Science::Digital LibrariesPhysical Review
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First observation of a baryonic Bc+ decay

2014

A baryonic decay of the $B_c^+$ meson, $B_c^+\to J/\psi p\overline{p}\pi^+$, is observed for the first time, with a significance of $7.3$ standard deviations, in $pp$ collision data collected with the LHCb detector and corresponding to an integrated luminosity of $3.0$ fb$^{-1}$ taken at center-of-mass energies of $7$ and $8$ $\mathrm{TeV}$. With the $B_c^+\to J/\psi \pi^+$ decay as normalization channel, the ratio of branching fractions is measured to be \begin{equation*} \frac{\mathcal{B}(B_c^+\to J/\psi p\overline{p}\pi^+)}{\mathcal{B}(B_c^+\to J/\psi \pi^+)} = 0.143^{\,+\,0.039}_{\,-\,0.034}\,(\mathrm{stat})\pm0.013\,(\mathrm{syst}). \end{equation*} The mass of the $B_c^+$ meson is dete…

Nuclear TheoryAnalytical chemistryGeneral Physics and Astronomy01 natural sciencesSettore FIS/04 - Fisica Nucleare e SubnucleareHigh Energy Physics - ExperimentHigh Energy Physics - Experiment (hep-ex)[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]TOOLFactorizationNuclear ExperimentQCPhysicsPhysicsParticle physics12.39.StPhysical SciencesComputer Science::Mathematical SoftwareFísica nuclearLHCMESONParticle Physics - ExperimentComputer Science::Machine LearningMeson530 Physics14.40.NdPhysics MultidisciplinaryFOS: Physical sciencesPhysics InstituteLHCb - Abteilung HofmannAstrophysics::Cosmology and Extragalactic AstrophysicsComputer Science::Digital LibrariesNONuclear physicsPhysics and Astronomy (all)Hadronic decays of bottom meson0103 physical sciencesPi010306 general physicsScience & Technology010308 nuclear & particles physicshep-exHigh Energy Physics::Phenomenologymeson; toolBaryonLHCb13.25.HwBottom mesons (|B|>0)High Energy Physics::ExperimentFísica de partículesExperiments
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Electromagnetic moments of scandium isotopes and $N=28$ isotones in the distinctive $0f_{7/2}$ orbit

2022

The electric quadrupole moment of $^{49}$Sc was measured by collinear laser spectroscopy at CERN-ISOLDE to be $Q_{\rm s}=-0.159(8)$ $e$b, and a nearly tenfold improvement in precision was reached for the electromagnetic moments of $^{47,49}$Sc. The single-particle behavior and nucleon-nucleon correlations are investigated with the electromagnetic moments of $Z=21$ isotopes and $N=28$ isotones as valence neutrons and protons fill the distinctive $0f_{7/2}$ orbit, respectively, located between magic numbers, 20 and 28. The experimental data are interpreted with shell-model calculations using an effective interaction, and ab-initio valence-space in-medium similarity renormalization group calcu…

Nuclear and High Energy PhysicsNuclear Theorynucl-thCollinear laser spectroscopyNuclear TheoryFOS: Physical sciencesAstronomy & Astrophysicsnucl-exComputer Science::Digital LibrariesPhysics Particles & FieldsElectromagnetic momentsNuclear Theory (nucl-th)Nuclear Physics - ExperimentNuclear Experiment (nucl-ex)Nuclear ExperimentNuclear ExperimentisotoopitScience & TechnologyPhysicsNUCLEAR MOMENTSQUADRUPOLE-MOMENTSPhysics NuclearNucleon-nucleon correlationNuclear Physics - TheoryPhysical SciencesSHELL-MODELCOLLECTIVITYPräzisionsexperimente - Abteilung BlaumydinfysiikkaskandiumAb-initio calculation
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Measurement of the mass of the W boson using direct reconstruction at √s = 183 GeV

1999

From data corresponding to an integrated luminosity of 53.5 pb(-1) taken during the 183 GeV run in 1997, DELPHI has measured the W mass from direct reconstruction of WW --> lq (q) over bar and WW --> q (q) over bar q (q) over bar events. Combining these channels, a value of m(w) = 80.238 +/- 0.154(stat) +/- 0.035(syst) +/- 0.035(fsi) +/- 0.021 (LEP) GeV/c(2) is obtained, where fsi denotes final state interaction. Combined with the W mass obtained by DELPHI from the WW production cross-section and with the direct measurement at 172 GeV this leads to a measured value of m(w) = 80.270 +/- 0.137(stat) +/- 0.031(syst) +/- 0.030(fsi) +/- 0.021(LEP)GeV/c(2), in good agreement with the Standard Mod…

Nuclear and High Energy PhysicsParticle physicsEINSTEIN CORRELATIONSCLUSTERING-ALGORITHMElectron–positron annihilationMathematicsofComputing_GENERALCOLOR DIPOLE MODEL01 natural sciencesComputer Science::Digital LibrariesPartícules (Física nuclear)LuminosityStandard ModelPHYSICSEVENTSNuclear physicsLEP20103 physical sciencesMONTE-CARLO PROGRAM[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]ANNIHILATION010306 general physicsDELPHIPhysicsAnnihilation010308 nuclear & particles physicsE(+)E(-) INTERACTIONSTheoryofComputation_GENERALLARGE ELECTRON POSITRON COLLIDERMONTE-CARLO PROGRAM; PAIR CROSS-SECTION; COLOR DIPOLE MODEL; E(+)E(-) INTERACTIONS; EINSTEIN CORRELATIONS; CLUSTERING-ALGORITHM; ANNIHILATION; PHYSICS; EVENTS; LEP2PARTICLE PHYSICS; LARGE ELECTRON POSITRON COLLIDER; DELPHIComputer Science::Mathematical SoftwarePARTICLE PHYSICSProduction (computer science)Física nuclearPAIR CROSS-SECTIONParticle Physics - ExperimentBar (unit)
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A measurement of the \(\tau\) leptonic branching fractions

1995

Abstract: A sample of 25000 Z(0) --> tau(-)tau(+) events collected by the DELPHI experiment at LEP in 1991 and 1992 is used to measure the leptonic branching fractions of the tau lepton. The results are B(tau --> e nu) = (17.51+/-0.39)% and B(tau --> mu nu) = (17.02+/-0.31)%. The ratio of the muon and electron couplings to the weak charged current is measured to be g(mu)/g(e) = 1.000+/-0.013, satisfying e-mu universality. The average leptonic branching fraction corrected to the value for a massless lepton, assuming e-mu universality, is found to be B(tau --> l nu) = (17.50+/-0.25)%.

Nuclear and High Energy PhysicsParticle physicsElectron–positron annihilationElectronComputer Science::Digital Libraries01 natural sciencesPartícules (Física nuclear)Nuclear physics0103 physical sciences[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]010306 general physicslepton couplingCharged currentDELPHIPhysicsMuon010308 nuclear & particles physicsBranching fractionPhysicsHigh Energy Physics::Phenomenologytau leptonLARGE ELECTRON POSITRON COLLIDERUniversality (dynamical systems)Massless particlePARTICLE PHYSICS; LARGE ELECTRON POSITRON COLLIDER; DELPHIComputer Science::Mathematical SoftwarePARTICLE PHYSICSHigh Energy Physics::ExperimentFísica nuclearParticle Physics - ExperimentDELPHI; tau lepton; lepton couplingLepton
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Issues and Opportunities in Exotic Hadrons

2016

The last few years have been witness to a proliferation of new results concerning heavy exotic hadrons. Experimentally, many new signals have been discovered that could be pointing towards the existence of tetraquarks, pentaquarks, and other exotic configurations of quarks and gluons. Theoretically, advances in lattice field theory techniques place us at the cusp of understanding complex coupled-channel phenomena, modelling grows more sophisticated, and effective field theories are being applied to an ever greater range of situations. It is thus an opportune time to evaluate the status of the field. In the following, a series of high priority experimental and theoretical issues concerning h…

Nuclear and High Energy PhysicsParticle physicsField (physics)Lattice field theoryhep-latFOS: Physical sciencesAtomic01 natural sciencesComputer Science::Digital Libraries530Particle and Plasma PhysicsHigh Energy Physics - LatticeHigh Energy Physics - Phenomenology (hep-ph)0103 physical sciencesNuclearddc:530010306 general physicsNuclear ExperimentInstrumentationPhysics010308 nuclear & particles physics[PHYS.HLAT]Physics [physics]/High Energy Physics - Lattice [hep-lat]High Energy Physics::PhenomenologyHigh Energy Physics - Lattice (hep-lat)Molecularhep-phAstronomy and AstrophysicsExotic hadronNuclear & Particles PhysicsHigh Energy Physics - Phenomenology[PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph]Quark–gluon plasmaHigh Energy Physics::Experiment
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