Search results for "liha"
showing 10 items of 620 documents
Differentiation of Murine C2C12 Myoblasts Strongly Reduces the Effects of Myostatin on Intracellular Signaling
2020
Alongside in vivo models, a simpler and more mechanistic approach is required to study the effects of myostatin on skeletal muscle because myostatin is an important negative regulator of muscle size. In this study, myostatin was administered to murine (C2C12) and human (CHQ) myoblasts and myotubes. Canonical and noncanonical signaling downstream to myostatin, related ligands, and their receptor were analyzed. The effects of tumorkines were analyzed after coculture of C2C12 and colon cancer-C26 cells. The effects of myostatin on canonical and noncanonical signaling were strongly reduced in C2C12 cells after differentiation. This may be explained by increased follistatin, an endogenous blocke…
Energy cost of individual lower leg muscles in walking : comparison between young and elderly men at different walking speeds
2015
The cost of transport (COT) in elderly subjects is increased in comparison to young adults, independently of the walking speed. The changes in the neuromuscular activity of the lower extremity muscles could explain this phenomenon. The objective of this thesis was to qualitatively compare the muscle activity pattern of the lower extremities between healthy young and elderly subjects, over a range of walking speeds in order to infer the contributions of individual muscles to changes in COT in both age groups. 26 participants were recruited (13 young aged 18-30; 13 old aged 70-80). Mean oxygen consumption was used to calculate COT and electromyography signals from 10 leg muscles were used to …
Three-dimensional architecture of the whole human soleus muscle in vivo
2018
Background Most data on the architecture of the human soleus muscle have been obtained from cadaveric dissection or two-dimensional ultrasound imaging. We present the first comprehensive, quantitative study on the three-dimensional anatomy of the human soleus muscle in vivo using diffusion tensor imaging (DTI) techniques. Methods We report three-dimensional fascicle lengths, pennation angles, fascicle curvatures, physiological cross-sectional areas and volumes in four compartments of the soleus at ankle joint angles of 69 ± 12° (plantarflexion, short muscle length; average ± SD across subjects) and 108 ± 7° (dorsiflexion, long muscle length) of six healthy young adults. Microdissection and…
Individual and combinatory effects of voluntary wheel running and sActRIIB-Fc administration on redox-balance in mdx mice
2015
Duchenne’s muscular dystrophy (DMD) is X-chromosome linked muscle wasting dis-ease. It is caused by a mutation in the gene coding protein called dystrophin leading to premature death and significantly impairing the quality of life of DMD patients. Oxida-tive stress is a contributing factor in the pathology of DMD. Light intensity exercise and interventions that promote sirtuin (SIRT) 1 activity have been shown to be antioxidant for mdx mice and to ameliorate the symptoms of DMD. Also blocking activin receptor IIB (ActRIIB) ligands has been shown in some, but not all studies to improve the pa-thology of the DMD. The purpose of this study was to find out the individual and com-binatory effect…
Mobility decline in old age.
2012
Mobility is important for community independence. With increasing age, underlying pathologies, genetic vulnerabilities, physiological and sensory impairments, and environmental barriers increase the risk for mobility decline. Understanding how mobility declines is paramount to finding ways to promote mobility in old age. peerReviewed
Supervised Physical Training Enhances Muscle Strength but Not Muscle Mass in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Syst…
2019
Introduction: Androgen deprivation therapy (ADT) is considered the basic treatment for advanced prostate cancer, but it is highly associated with detrimental changes in muscle mass and muscle strength. The aim of this meta-analysis was to investigate the effects of supervised physical training on lean mass and muscle strength in prostate cancer patients undergoing ADT. Methods: A systematic literature search was performed using MEDLINE, Embase, and ScienceDirect until October 2018. Only studies that examined both muscle mass and strength in prostate cancer patients undergoing ADT were included. Outcomes of interest were changes in lean body mass (surrogate for muscle mass) as well as upper …
MARP - proteiiniperheen proteiinien mRNA –määrät venymis - lyhenemissykli -tyyppisen kuormituksen jälkeen
2010
Riina Flink. 2010. MARP – proteiiniperheen proteiinien mRNA – määrät venymis – lyhenemissykli – tyyppisen – kuormituksen jälkeen. Kandidaatin tutkielma, Liikuntafysiologia. Liikuntabiologian laitos, Jyväskylän yliopisto. 37s. MARP (muscle ankyrin repeat protein) – proteiiniperheen proteiinien arvellaan olevan mukana etenkin luurankolihaksen adaptoitumisessa paljon eksentristä lihasliikettä sisältävään harjoitukseen. Arvellaan, että ne saattavat ehkäistä muun muassa soluvaurioilta. Niiden ilmenemistä fyysisen rasituksen yhteydessä on kuitenkin tutkittu ihmisillä vasta yhdessä tutkimuksessa (Lehti ym .2009) ja tietoa tarvitaan lisää. Tämän tutkimuksen tarkoituksena olikin tutkia, miten CARP:i…
Comparing the Ecotoxicological Effects of Perfluorooctanoic Acid (PFOA) and Perfluorohexanoic Acid (PFHxA) on Freshwater Microbial Community
2022
The ubiquitous presence of perfluorinated carboxylic acids (PFCAs) around the globe has attracted increasing attention, due to their persistency, bioaccumulation, and toxicity. Nevertheless, the ecotoxicological effects of the compounds on aquatic microorganisms has remained understudied. Hence, the present study focused on determining, and comparing, the effects of regulated long-chain PFCA, perfluorooctanoic acid (PFOA), and nonregulated short-chain PFCA, perfluorohexanoic acid (PFHxA), on the diversity, structure, microbial growth, and activity of a freshwater microbial community. In the experiment, lake water was incubated for a period of four weeks at three different concentrations of …
Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight
2021
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia…
Maternal adiposity in pregnancy and offspring asthma in adulthood.
2018
High maternal body mass index in pregnancy was associated with an increased prevalence of offspring asthma in men in adult life