Search results for "linear"
showing 10 items of 7165 documents
Assessing Causality in normal and impaired short-term cardiovascular regulation via nonlinear prediction methods
2009
We investigated the ability of mutual nonlinear prediction methods to assess causal interactions in short-term cardiovascular variability during normal and impaired conditions. Directional interactions between heart period (RR interval of the ECG) and systolic arterial pressure (SAP) short-term variability series were quantified as the cross-predictability (CP) of one series given the other, and as the predictability improvement (PI) yielded by the inclusion of samples of one series into the prediction of the other series. Nonlinear prediction was performed through global approximation (GA), approximation with locally constant models (LA0) and approximation with locally linear models (LA1) …
A multicenter, double-blind, randomized, placebo-controlled trial of the β3-adrenoceptor agonist solabegron for overactive bladder
2012
Abstract Background β-Adrenoceptor agonists are effective in animal models of bladder dysfunction, and the human bladder primarily expresses the β3 receptor subtype. Objective To evaluate the efficacy and tolerability of the highly selective and potent β3-adrenoceptor agonist solabegron in a clinical proof-of-concept study in incontinent women with overactive bladder (OAB). Design, setting, and participants This was a randomized, double-blind trial in adult women with OAB (one or more 24-h incontinence episodes and eight or more average 24-h micturitions). Interventions Solabegron 50mg ( n =88), solabegron 125mg ( n =85), or placebo ( n =85)—all twice daily—were administered. Outcome measur…
Comparison of UV and charged aerosol detection approach in pharmaceutical analysis of statins
2009
Abstract CAD (charged aerosol detector) has recently become a new alternative detection system in HPLC. This detection approach was applied in a new HPLC method for the determination of three of the major statins used in clinical treatment—simvastatin, lovastatin and atorvastatin. The method was optimized and the influence of individual parameters on CAD response and sensitivity was carefully studied. Chromatography was performed on a Zorbax Eclipse XDB C18 (4.6 mm × 75 mm, 3.5 μm), using acetonitrile and formic acid 0.1% as mobile phase. The detection was performed using both CAD (20 pA range) and DAD (diode array detector—238 nm) simultaneously connected in series. In terms of linearity, …
On reliability of systems with moving material subjected to fracture and instability
2015
Abstract The reliability of systems with moving cracked elastic and isotropic material is considered. The material is modeled as a moving plate which continually has a crack on the edge. The plate is subjected to homogeneous tension acting in the traveling direction and the tension varies temporally around a constant value, the set tension. The tension and the length of the crack are modeled by an Ornstein–Uhlenbeck process and an exponential Ornstein–Uhlenbeck process, respectively. Failure is regarded as the state at which the plate becomes unstable or fractures (or both) and a lower bound for the reliability of the system is derived. Considering reliability of the system leads to first p…
Stochastic analysis of the critical velocity of an axially moving cracked elastic plate
2014
In this study, a probabilistic analysis of the critical velocity for an axially moving cracked elastic and isotropic plate is presented. Axially moving materials are commonly used in modelling of manufacturing processes, like paper making and plastic forming. In such systems, the most serious threats to runnability are instability and material fracture, and finding the critical value of velocity is essential for efficiency. In this paper, a formula for the critical velocity is derived under constraints for the probabilities of instability and fracture. The significance of randomness in different model parameters is investigated for parameter ranges typical of paper material and paper machin…
TAKEOFF AND LANDING ROBUST CONTROL SYSTEM FOR A TANDEM CANARD UAV
2005
In spite of modern wide improvements in UAV’s technologies, a few number of such a vehicles is fully autonomous from takeoff to landing . So, either autonomous operation or operation with minimal human intervention is, actually, the primary design goal for the UAV’s researchers. The core of the problem is the design of the landing and takeoff control system. The objective of this paper is to design a control system in which the same state variables are controlled during both the descending/ascending path and the flare, tacking into account the actual ground effect. Robust control techniques are employed with the aim to cope with atmospheric turbulence, measurement noise, parameter variation…
Aggression towards Referees in Amateur Football in Spain: A Loglinear Approach
2019
Aggressive behavior towards football referees is becoming increasingly common, and as a result we are getting used to it and coming to see it as an inevitable and intrinsic element of football matches. Spectators, players and coaches are all prone to take this view. This article studies how the types of aggression shown by these three groups towards the referee are related to one another, and how they are perceived by the referee, in amateur football. For this purpose, the phenomenon was assessed, using an ad-hoc form, both by an expert and by the referee, in 119 regional and youth football matches in the city of Valencia and surrounding municipalities. We analysed the data using a loglinea…
Estimating COVID-19-induced Excess Mortality in Lombardy, Italy.
2022
We compare the expected all-cause mortality with the observed one for different age classes during the pandemic in Lombardy, which was the epicenter of the epidemic in Italy. The first case in Italy was found in Lombardy in early 2020, and the first wave was mainly centered in Lombardy. The other three waves, in Autumn 2020, March 2021 and Summer 2021 are also characterized by a high number of cases in absolute terms. A generalized linear mixed model is introduced to model weekly mortality from 2011 to 2019, taking into account seasonal patterns and year-specific trends. Based on the 2019 year-specific conditional best linear unbiased predictions, a significant excess of mortality is estima…
Determination of the modulus of elasticity of bone material by an acoustical approach at the forearm distinguishes women with and without vertebral f…
2002
The modulus of elasticity is a parameter characterizing fracture stability of bone independent of bone mineral density. Measurement of acoustical properties of the forearm by determination of the resonant frequency of the ulna in longitudinal direction as a function of sound transmission velocity after adjustment of the measuring result by ulna length yields information about the modulus of elasticity. It was the aim of this study to investigate whether this parameter may distinguish between subjects with and without vertebral fractures independent of bone mineral density. Fifty females (61.1 +/- 9.1 years) were enrolled into the study, 25 with, and 25 age-matched without prevalent osteopor…
Seasonal changes in host phenotype manipulation by an acanthocephalan: time to be transmitted?
2009
Parasitology, 136 (2)