Search results for "lino"

Pericle e il muro di Berlino : l’arte della separazione tra stati murati e costituzionalismo

2021

Il discorso del presidente Kennedy davanti il muro di Berlino rappresenta il culmine di una tradizione intellettuale occidentale incentrata sulla dicotomia tra libertà e dispotismo. Così il muro diventa il simbolo di un duplice metafora: del costituzionalismo, nella visione occidentale quale separazione dei poteri; e della società chiusa e liberticida, quando il regime totalitario recinge e opprime gli individui e i loro diritti fondamentali.

Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-β

2009

Aims We have recently shown that urokinase plasminogen activator (uPA) increases oxidative stress (OS), cholesterol biosynthesis, and paraoxonase 2 (PON2) expression in macrophages via binding to its receptor, the uPAR. Since PON2 is regulated by both OS and cholesterol content, we hypothesized that uPA elicits a cascade of signal transduction events shared by NADPH oxidase and cholesterol biosynthesis that culminates in PON2 gene expression. Here, we investigated the signalling pathway that leads to the expression of PON2 in macrophages in response to uPA. Methods and results The increase in macrophage PON2 mRNA levels in response to uPA was shown to depend on PON2 gene promoter activation…

Regulation ofMUC1Expression in Human Mammary Cell Lines by the c-ErbB2 and Ras Signaling Pathways

2001

The MUC1 protein is a highly O-glycosylated transmembrane molecule that is expressed at the luminal surface of most glandular epithelial cells and is upregulated in carcinomas. Here, we report the effect of the activation of the c-ErbB2 --Ras pathway on the expression of the MUC1 gene in the nontumorigenic mammary cell lines MTSV1-7 and HB2 and in the malignant cell lines T47D and ZR75. Endogenous levels of MUC1 mRNA and protein in HB2 clones permanently overexpressing c-ErbB2 or V12-H-Ras were markedly reduced compared with levels in the parental cell lines. Furthermore, in transient transfection assays, the transcription of a CAT reporter construct driven by the MUC1 promoter was inhibite…

Regulation of the peroxisomal β-oxidation-dependent pathway by peroxisome proliferator-activated receptor α and kinases

2000

The first PPAR (peroxisome proliferator-activated receptor) was cloned in 1990 by Issemann and Green (Nature 347:645-650). This nuclear receptor was so named since it is activated by peroxisome proliferators including several drugs of the fibrate family, plasticizers, and herbicides. This receptor belongs to the steroid receptor superfamily. After activation by a specific ligand, it binds to a DNA response element, PPRE (peroxisome proliferator response element), which is a DR-1 direct repeat of the consensus sequence TGACCT x TGACCT. This mechanism leads to the transcriptional activation of target genes (Motojima et al., J Biol Chem 273:16710-16714, 1998). After the first discovery, severa…

Impairing Otp homeodomain function in oral ectoderm cells affects skeletogenesis in sea urchin embryos

2003

AbstractIn the sea urchin embryo skeletogenesis is the result of a complex series of molecular and cellular events that coordinate the morphogenetic process. Past and recent evidence strongly indicate that skeletal initiation and growth are strictly dependent on signals emanating from the oral ectodermal wall. As previously suggested, Orthopedia (Otp), a homeodomain-containing transcription factor specifically expressed in a small subset of oral ectoderm cells, might be implicated in this signalling pathway. In this study, we utilize three different strategies to address the issue of whether Otp is an upstream regulator of sketelogenesis. We describe the effects of microinjection of Otp mor…

Diarylprolinol as a Ligand for Enantioselective Alkynylation of Cyclic Imines

2017

An easily accessible prolinol derived ligand, (S)-bis(3,5-bis(trifluoromethyl)phenyl)(pyrrolidin-2-yl)methanol, has been efficiently applied in the catalytic enantioselective addition of terminal alkynes to cyclic imines using dimethylzinc (Me2Zn) under mild reaction conditions. The developed catalytic system led to chiral propargylic sulfamidates with high yields (up to 97%) and excellent enantioselectivities (up to 97% ee).

Estimación de dosis en aplicaciones radiológicas basada en la dosimetría por luminiscencia ópticamente estimulada

2016

La Comisión Internacional de Protección Radiológica (ICRP) ha recomendado una reducción del límite de dosis equivalente en cristalino para los trabajadores ocupacionalmente expuestos de 150 mSv por año (ICRP-2007, Publicación 103) a un promedio de 20 mSv por año durante cinco años o 50 mSv en un año (ICRP-2012, Publicación 118). Actualmente, no existe una dosimetría rutinaria y sistemática para medir la dosis equivalente en cristalino; sólo se hace una extrapolación de los valores medidos por los dosímetros personales. El objetivo de este estudio es estimar la dosis equivalente en superficie que recibe el personal sanitario en cristalino y manos para los procedimientos de cirugía de muñeca …

Juana Francés siempre en la vanguardia. Sus etapas artísticas

2011

AKT I / ACTO I / CT I Männer / Hombres / Men Chopins Männer / Los hombres de Chopin / Chopin?s Men

2021

Este ensayo se centra en la vida privada y amorosa del compositor polaco-francés Frédéric Chopin. Además de la bibliografía secundaria reciente, como algunas biografías, el texto se basa principalmente en un análisis de la correspondencia de Chopin, una parte importante de la cual ha sido publicada en muchas ediciones y traducida del polaco o el francés a varios idiomas. Mi investigación muestra que muchas de estas ediciones traducidas contienen irregularidades, como pronombres masculinos polacos originales que han sido traducidos como pronombres femeninos, o notas a pie de página que carecen de referencias. Esto ha obstaculizado una biografía completa de Chopin durante décadas. Esta invest…

Algunas cuestiones en torno a la historia antigua de la Iglesia Romana.

2002

Fernandez Hernandez, Gonzalo M. - Gonzalo.Fernandez@uv.es