Search results for "lipid nanoparticles"

showing 4 items of 34 documents

In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate

2019

Idebenone (IDE) is a strong antioxidant that has been proposed for the treatment of skin disorders, including skin ageing. Unfavorable physico-chemical properties make IDE a poor skin permeant where effectiveness could be improved by its loading into suitable delivery systems such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). In this work, we designed novel IDE-loaded NLC containing tocopheryl acetate (VitE) as a liquid component to obtain a synergic effect between IDE and VitE. The resulting NLC showed small particle sizes (24&ndash

antioxidantAntioxidantDPPHmedicine.medical_treatment02 engineering and technologylipid nanoparticlesPharmacologytocopheryl acetatemedicine.disease_causelcsh:Technology030226 pharmacology & pharmacylcsh:Chemistry03 medical and health scienceschemistry.chemical_compoundphoto-protective effect0302 clinical medicineIn vivoSolid lipid nanoparticlemedicineIdebenoneGeneral Materials Scienceskin hydrationlcsh:QH301-705.5InstrumentationFluid Flow and Transfer ProcessesIdebenonelcsh:TChemistryProcess Chemistry and TechnologyGeneral EngineeringIn vitro toxicologytopical administrationlipid nanoparticle021001 nanoscience & nanotechnologylcsh:QC1-999kin hydrationComputer Science Applicationsantioxidantslcsh:Biology (General)lcsh:QD1-999Idebenone; tocopheryl acetate; lipid nanoparticles; antioxidants; topical administration; skin hydration; photo-protective effectlcsh:TA1-2040Tocopheryl acetatelcsh:Engineering (General). Civil engineering (General)0210 nano-technologylcsh:PhysicsOxidative stressmedicine.drugApplied Sciences
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Effect of composition of Solid Lipid Nanoparticles on their chemical-physical properties and potential for gene therapy

2015

nanoparticles gene therapyLIPID NANOPARTICLESGENE THERAPYSURFACTANT
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SOLID LIPID NANOPARTICLES CONTAINING AN ANTIOXIDANT COMPOUND IN ALZHEIMER’S DISEASE

2008

solid lipid nanoparticles drug delivery alzheimer's diseaseSettore CHIM/09 - Farmaceutico Tecnologico Applicativo
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SOLID LIPID NANOPARTICLES (SLNs) CONTAINING FERULIC ACID AGAINST OXIDATIVE STRESS IN NEURODEGENERATIVE DISEASES

2008

solid lipid nanoparticles ferulic acid neurodegenerative diseases.Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
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