Search results for "liquid"

Retention–property relationships of anticonvulsant drugs by biopartitioning micellar chromatography

2001

Epilepsy may be considered as a group of disorders with only one thing in common: the fact that recurrent anomalous electrochemical phenomena appear in the central nervous system. Different classes of drugs are included under the generic term of anticonvulsant drugs. All of them work by decreasing discharge propagation in different ways. Biopartitioning micellar chromatography (BMC) is a mode of reversed-phase liquid chromatography, which can be used as an in vitro system to model the biopartitioning process of drugs when there are no active processes. In this paper, relationships between the BMC retention data of anticonvulsant drugs, their pharmacokinetics (oral absorption, protein bindin…

Retention pharmacokinetic and pharmacodynamic parameter relationships of antihistamine drugs using biopartitioning micellar chromatography

2001

Abstract Antihistamines are drugs which act by competitive inhibition of the H1 or H2 histamine receptors. Little has been known about their clinical pharmacokinetics and biological responses until the last few years. In this paper, we propose quantitative retention–activity relationship, QRAR, models based on the retention data of antihistamines in a biopartitioning micellar chromatography (BMC) system using a Brij35 mobile phase for describing pharmacokinetic parameters such as half-life and volume of distribution, or the pharmacodynamic parameters, therapeutic plasma levels, lethal doses and drug-receptor dissociation constant. The predictive ability of these models is statistically vali…

What really causes large price changes?

2003

We study the cause of large fluctuations in prices in the London Stock Exchange. This is done at the microscopic level of individual events, where an event is the placement or cancellation of an order to buy or sell. We show that price fluctuations caused by individual market orders are essentially independent of the volume of orders. Instead, large price fluctuations are driven by liquidity fluctuations, variations in the market's ability to absorb new orders. Even for the most liquid stocks there can be substantial gaps in the order book, corresponding to a block of adjacent price levels containing no quotes. When such a gap exists next to the best price, a new order can remove the best q…

La città liquida: il waterfront come generatore di creatività urbana

2012

Le nuove dinamiche produttive, gli interventi di sviluppo sostenibile e le domande di conservazione del patrimonio architettonico che oggi investono le aree di waterfront delle città rappresentano un importante spunto di riflessione in una fase in cui il tema della rigenerazione delle “città d’acqua” sta aprendosi a nuove opportunità di trasformazione urbana e territoriale, agendo in maniera attiva nello scenario della produzione della qualità urbana. La rilevanza assunta negli ultimi anni dalle trasformazioni urbane in area di waterfront storici delle città ha, infatti, aperto nuove prospettive – e le conseguenti sfide – per la ricerca sulle condizioni di rischio, sulle pressioni antropich…

Projected WIMP sensitivity of the XENONnT dark matter experiment

2020

XENONnT is a dark matter direct detection experiment, utilizing 5.9 t of instrumented liquid xenon, located at the INFN Laboratori Nazionali del Gran Sasso. In this work, we predict the experimental background and project the sensitivity of XENONnT to the detection of weakly interacting massive particles (WIMPs). The expected average differential background rate in the energy region of interest, corresponding to (1, 13) keV and (4, 50) keV for electronic and nuclear recoils, amounts to 12.3 ± 0.6 (keV t y)-1 and (2.2± 0.5)× 10−3 (keV t y)-1, respectively, in a 4 t fiducial mass. We compute unified confidence intervals using the profile construction method, in order to ensure proper coverage…

Adding the Mureş River Basin (Transylvania, Romania) to the List of Hotspots with High Contamination with Pharmaceuticals

2020

Background: The Mureș River Basin is a long-term heavily polluted watershed, in a situation of climate changes with increasing water flow and related decreasing dilution capacity. Here, a mixture of emerging pollutants such as pharmaceuticals were targeted to reveal potential risks regarding the natural lotic ecosystems. Due to the continuous discharge into the environment, pharmaceuticals are gaining persistent organic pollutant characteristics and are considered emerging pollutants. Based on the hazard quotient, this research highlights the dangerous concentrations of carbamazepine, ibuprofen, furosemide, and enalapril in river water. Results: High levels of four pharmaceutical compounds …

Characterizing weld pool surfaces from polarization state of thermal emissions

2013

International audience; In this Letter, a vision-based remote sensing methodology is proposed to measure the topography of weld pool surfaces from one single view. Thermal radiations emitted by the hot liquid metal at a wavelength within the arc plasma blind spectral window are acquired by a wavefront division polarimetric system. The refractive index of the liquid metal and the topography of the weld pool surface are inferred from the polarimetric state of the thermal radiations.

Dynamic wavefront sensing and correction with low-cost twisted nematic spatial light modulators

2010

Off-the-shelf spatial light modulators (SLMs), like twisted nematic liquid crystal displays (TNLCDs) used in projection systems, show some interesting features such as high spatial resolution, easy handling, wide availability, and low cost. We describe a compact adaptive optical system using just one TNLCD to measure and compensate optical aberrations. The current system operates at a frame rate of the order of 10 Hz with a four-level codification scheme. Wavefront estimation is performed through conventional Hartmann–Shack sensing architecture. The system has proved to work properly with a maximum rms aberration of 0. 76 μm and wavefront gradient of 50 rad/mm at a wavelength of 514 nm. The…

Determination of 5-nitrofurylacrylic acid in wines by high-performance liquid chromatography

1988

HPLC determination of volatile phenols in wines

1993

An alternative to the traditional solvent extraction method used to extract and rapidly quantify ethyl-and vinylphenol and ethyl-and vinylgaiacol from wine is presented. The method is based on retention of volatile phenols on adsorbants. Among the tested resins, the most efficient, AG 2-X8 (anion exchange resin), worked as well with a synthetic solution as with wines. The percolation of clarified wine adjusted to pH 9 on this resin permits, in particular, the elimination of organic acids. Phenols are not eluted after rinsing the column with 1N HCl, but are eluted with methanol after this treatment. Good recovery (91 %) and good repeatability are observed. The eluate is directly analysed by …