Search results for "live"

Buccal Thin Films as Potent Permeation Enhancers for Cytisine Transbuccal Delivery

2022

Cytisine (CYT) is a powerful anti-smoking compound which could greatly benefit from transbuccal delivery because of both its unfavorable pharmacokinetics after oral administration and its intrinsic ability to permeate the buccal mucosa. This work aims to design CYT-loaded buccal thin films suitable for transbuccal drug delivery due to its capability of promoting the interaction between CYT and the buccal membrane. The solvent casting method was employed to prepare several thin films combining various excipients such as matrixing polymers, mucoadhesion agents, plasticizers and other compounds as humectants and sweeteners, component ratios and solvents. A total of 36 compositions was prepared…

Inulin-Based Polymeric Micelles Functionalized with Ocular Permeation Enhancers: Improvement of Dexamethasone Permeation/Penetration through Bovine C…

2021

Ophthalmic drug delivery is still a challenge due to the protective barriers of the eye. A common strategy to promote drug absorption is the use of ocular permeation enhancers, while an innovative approach is the use of polymeric micelles. In the present work, the two mentioned approaches were coupled by conjugating ocular permeation enhancers (PEG2000, carnitine, creatine, taurine) to an inulin-based co-polymer (INU-EDA-RA) in order to obtain self-assembling biopolymers with permeation enhancer properties for the hydrophobic drug dexamethasone (DEX). Inulin derivatives were properly synthetized, were found to expose about 2% mol/mol of enhancer molecules in the side chain, and resulted abl…

La differenza femminile alla luce della fenomenologia. A partire da Hedwig Conrad-Martius

2018

The paper aims at presenting the theoretical pathway of one of Husserl's first students, Hedwig Conrad-Martius, and the influence she had first of all on Edith Stein, secondarily on Gerda Walther. The underlying research question could be summarized as follows: is it possible to trace a specific female perspective on phenomenology? The essay shows how the three phenomenologists considered are united by the interest, of great importance for pedagogy, for the theme of personhood and the constant attempt to study the human soul, in its relationship with the lived body but above all with the attention always devoted to a specific consideration of the spiritual dimension. The paper aims at prese…

Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits

2014

In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a single nucleotide in the APOB mRNA by the APOBEC1 enzyme. The APOB48 protein is mandatory for the synthesis of chylomicrons by intestinal cells to transport dietary lipids and cholesterol. We produced transgenic rabbits expressing permanently and ubiquitously a small hairpin RNA targeting the rabbit APOBEC1 mRNA. These rabbits exhibited a moderately but significantly reduced …

Impact of Genetic and Cultural Factors on Extra-Virgin Olive Oil Composition

Root and crown rot of olive caused by Phytophthora spp

2011

Występowanie Ricciocarpos natans (Marchantiophyta) na Śląsku

2017

The occurrence of Ricciocarpos natans (L.) Corda in Silesia (SW Poland) is discussed in its geographical and phytosociological aspects. The paper lists localities of this species and indicates its occurrence in plant communities, with special attention to Ricciocarpetum natantis an association rare and threatened in Poland. Ricciocarpos natans is a fairly common species in Silesia, known from 70 stations. Patches of Ricciocarpetum natantis are documented from 11 localities.

Viidennen sukupolven matkapuhelinverkkojen arkkitehtuuri

2017

Tulevaisuudessa maailman mobiiliverkoissa kulkevan datan määrä kasvaa yhä kiihtyvällä tahdilla ja kirjallisuudessa on siksi pohdittu mobiiliverkkojen seuraavaa suurta kehitysaskelta. Tässä tutkielmassa käydään läpi viidennen sukupolven matkapuhelinverkoissa hyödynnettäviä teknologioita, sekä mahdollisia tapoja rakentaa 5g-verkko. Etenkin suurta verkon kapasiteettia vaativilla alueilla verkon rakenne tulee muuttumaan ja tällöin mobiiliverkot eivät ole enää yhtä makrosolupainotteisia kuin ennen. In the future the amount of data in the world's mobile networks will increase and thus in literature there has been discussion about the next great step in the development of mobile networks. This the…

The management of crop-livestock systems at a territory level: the example of grain legume crops and of monogastric livestock in Burgundy, France

2012

Although cereals and oil seed crops are very developed in Burgundy, the area of grain legumes cultivation is small. Concerning monogastric livestock, the region is characterised by a medium size poultry production focussed on markets under quality and origin signs (SIQO) and a relatively small pig production. Although a tendency of co-location of these productions can be observed (at territory and farm scales) and some animals consume locally-produced proteins, there is no strong functional link between these crops and animal activities. This situation is confirmed by the fact that a significant proportion of produced grain legumes are exported by Burgundy, while large quantities of soybean…

Technical English for agriculture

2021

As the world goes global, the agricultural business needs to move across frontiers and oceans. Food, raw and processed, is regularly transported across continents. As space is no longer a limit for food trade and human nutrition, language cannot represent a barrier to this continuous exchange. In the last 60 years, English has been taking a foothold as the primary language for world trade and the exchange of agricultural goods is no exception. Agricultural sciences embrace a large number of disciplines, from botany to environmental physiology, from soil science to meteorology, from plant propagation to cultural management, from soil management to pest control, from field crops to animal husb…